Topography of the sleep/wake states related EEG microstructure and transitions structure differentiates the functionally distinct cholinergic innervation disorders in rat

Petrović, Jelena; Lazic, Katarina; Ciric, Jelena; Kalauzi, Aleksandar; Saponjic, Jasna

doi:10.1016/j.bbr.2013.07.047

Cited by 22 publications

(67 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our previous studies demonstrated, in the rat model of severely impaired cholinergic thalamo-cortical innervation (our rat model of Parkinson's disease cholinergic neuropathology or Parkinson's disease cholinopathy), topographically differentially expressed EEG microstructure within the sensorimotor and motor cortex during NREM and REM sleep, along with the appearance of two REM sleep states, particularly within the motor cortex [18,19]. Moreover, these distinct REM states were differentiated with regard to: EEG microstructure, EMG power, and sensorimotor and motor cortical drive to the dorsal nuchal muscles [20].…”

Section: Transl Brainmentioning

confidence: 99%

“…The surgical procedures employed for the EEG and EMG electrode implantation for chronic sleep recording and bilateral PPT lesion have been described previously [16][17][18][19][20][21][22][23][24], and are outlined below.…”

Section: Surgical Proceduresmentioning

confidence: 99%

“…We applied Fourier analysis to signals acquired throughout 6 h (2160 10 s Fourier epochs), and each 10 s epoch was differentiated, on the basis of EEG and EMG, as Wake, NREM, or REM sleep state (Figure 1). The differentiation of all Wake/NREM/REM sleep epochs was improved by using the logarithmic values of the quantities on both EEG and EMG axes, and was finally achieved using the two cluster K means algorithm [16,[18][19][20][21][22][23].…”

Section: Sleep Recording and Data Analysismentioning

confidence: 99%

“…To analyze REM sleep EEG microstructure, we calculated the group probability density distributions of all conventional EEG frequency bands relative amplitudes over 6 h, using the Probability Density Estimate (PDE) routine supplied by MATLAB R2011a [16,[18][19][20][22][23][24].…”

Section: Sleep Recording and Data Analysismentioning

confidence: 99%

“…The analysis of the recorded signals was conducted using software developed in MATLAB 6.5 [16,[18][19][20][21][22][23], and upgraded to MATLAB R2011a. We applied Fourier analysis to signals acquired throughout 6 h (2160 10 s Fourier epochs), and each 10 s epoch was differentiated, on the basis of EEG and EMG, as Wake, NREM, or REM sleep state (Figure 1).…”

Section: Sleep Recording and Data Analysismentioning

confidence: 99%

See 4 more Smart Citations

Sleep spindles as an early biomarker of REM sleep disorder in a rat model of Parkinson’s disease cholinopathy

Ciric¹,

Lazic²,

Petrović³

et al. 2017

Transl Brain Rhythmicity

View full text Add to dashboard Cite

Rhythmic oscillations of neuronal populations, generated by different mechanisms, are present at several levels of the central nervous system and serve many important physiological or reflect pathological functions. Understanding the role of brain oscillations as possible biomarkers of brain function and plasticity is still a challenge, and despite extensive research, their role is still not well established.We recently demonstrated that the hallmarks of earlier aging onset during impaired thalamo-cortical cholinergic innervation (in a rat model of Parkinson's disease cholinopathy) were consistently expressed, from 3 and one half to 5 and one half months of age, through increased electroencephalographic (EEG) sigma activity amplitude during rapid eye movement (REM) sleep, as a unique aging induced REM sleep phenomenon. In addition, there was altered motor cortical drive during non-rapid-eye-movement (NREM) and REM sleep.In order to explain this new aging-induced REM sleep phenomenon, we analyzed possible differences between control REM sleep spindle activity and REM sleep spindle activity at the onset of REM sleep "enriched" with sigma activity (at 4 and one half months of age), following bilateral pedunculopontine tegmental nucleus (PPT) cholinergic neuronal loss in the rat. We analzyed differences in spindle density, duration, and frequency.We demonstrated in young adult Wistar rats with the severely impaired PPT cholinergic innervation the alterations in sleep spindle dynamics and pattern during REM sleep in the motor cortex as the earliest biomarkers for the onset of their altered aging processes.

show abstract

Section: Transl Brainmentioning

confidence: 99%

Section: Surgical Proceduresmentioning

confidence: 99%

Section: Sleep Recording and Data Analysismentioning

confidence: 99%

Section: Sleep Recording and Data Analysismentioning

confidence: 99%

Section: Sleep Recording and Data Analysismentioning

confidence: 99%

See 3 more Smart Citations

Sleep spindles as an early biomarker of REM sleep disorder in a rat model of Parkinson’s disease cholinopathy

Ciric¹,

Lazic²,

Petrović³

et al. 2017

Transl Brain Rhythmicity

View full text Add to dashboard Cite

show abstract

Glial response in the rat models of functionally distinct cholinergic neuronal denervations

Bataveljić

Petrović

Lazic

et al. 2014

J of Neuroscience Research

Self Cite

View full text Add to dashboard Cite

Alzheimer's disease (AD) involves selective loss of basal forebrain cholinergic neurons, particularly in the nucleus basalis (NB). Similarly, Parkinson's disease (PD) might involve the selective loss of pedunculopontine tegmental nucleus (PPT) cholinergic neurons. Therefore, lesions of these functionally distinct cholinergic centers in rats might serve as models of AD and PD cholinergic neuropathologies. Our previous articles described dissimilar sleep/wake-state disorders in rat models of AD and PD cholinergic neuropathologies. This study further examines astroglial and microglial responses as underlying pathologies in these distinct sleep disorders. Unilateral lesions of the NB or the PPT were induced with rats under ketamine/diazepam anesthesia (50 mg/kg i.p.) by using stereotaxically guided microinfusion of the excitotoxin ibotenic acid (IBO). Twenty-one days after the lesion, loss of cholinergic neurons was quantified by nicotinamide adenine dinucleotide phosphate-diaphorase histochemistry, and the astroglial and microglial responses were quantified by glia fibrillary acidic protein/OX42 immunohistochemistry. This study demonstrates, for the first time, the anatomofunctionally related astroglial response following unilateral excitotoxic PPT cholinergic neuronal lesion. Whereas IBO NB and PPT lesions similarly enhanced local astroglial and microglial responses, astrogliosis in the PPT was followed by a remote astrogliosis within the ipslilateral NB. Conversely, there was no microglial response within the NB after PPT lesions. Our results reveal the rostrorostral PPT-NB astrogliosis after denervation of cholinergic neurons in the PPT. This hierarchically and anatomofunctionally guided PPT-NB astrogliosis emerged following cholinergic neuronal loss greater than 17% throughout the overall rostrocaudal PPT dimension.

show abstract

Preconscious Awareness

García‐Rill

2015

Waking and the Reticular Activating System in Health and Disease

View full text Add to dashboard Cite

Topography of the sleep/wake states related EEG microstructure and transitions structure differentiates the functionally distinct cholinergic innervation disorders in rat

Cited by 22 publications

References 54 publications

Sleep spindles as an early biomarker of REM sleep disorder in a rat model of Parkinson’s disease cholinopathy

Sleep spindles as an early biomarker of REM sleep disorder in a rat model of Parkinson’s disease cholinopathy

Glial response in the rat models of functionally distinct cholinergic neuronal denervations

Preconscious Awareness

Contact Info

Product

Resources

About