Topographical differences in the vascular permeability of the peripheral nervous system

Olsson, Yngve

doi:10.1007/bf00690507

Cited by 225 publications

(126 citation statements)

References 24 publications

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“…Therefore, the relatively high concentration of plasma proteins in the endoneurial interstitial fluid of peripheral myelinated nerves (OLSSON, 1975;VAN LIS and JENNEKENS, 1977) well reflects the leaky structure of the mesaxonal tight junction of the nerves.…”

Section: Discussionmentioning

confidence: 99%

Mesaxonal membrane junction of myelinated nerve in the central and peripheral nervous system.

Inokuchi

Higashi

1980

Arch. Histol. Jap., Arch. Histol. Jpn

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Section: Discussionmentioning

confidence: 99%

Mesaxonal membrane junction of myelinated nerve in the central and peripheral nervous system.

Inokuchi

Higashi

1980

Arch. Histol. Jap., Arch. Histol. Jpn

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“…Previously, demyelination of ventral root had been described in aged rats, but the sensory roots were unaffected (19). Lipid peroxidation effects are greater in nerve root and DRG because the blood-nerve and perineurial barriers are lower at these sites (20) and may contribute to the development of a radicular myelinopathy (14). Other investigators have confirmed these findings of mitochondrial pathology, including ballooning of mitochondria and disruption of the internal cristae as a result of the neurotoxic effects of glucose (2,(21)(22)(23).…”

Section: Diabetes Vol 52 January 2003mentioning

confidence: 97%

Oxidative Injury and Apoptosis of Dorsal Root Ganglion Neurons in Chronic Experimental Diabetic Neuropathy

2003

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We evaluated the effects of chronic hyperglycemia on L5 dorsal root ganglion (DRG) neurons using immunohistochemical and electrophysiologic techniques for evidence of oxidative injury. Experimental diabetic neuropathy was induced by streptozotocin. To evaluate the pathogenesis of the neuropathy, we studied peripheral nerve after 1, 3, and 12 months of diabetes. Electrophysiologic abnormalities were present from the first month and persisted over 12 months. 8-Hydroxy-2-deoxyguanosine labeling was significantly increased at all time points in DRG neurons, indicating oxidative injury. Caspase-3 labeling was significantly increased at all three time points, indicating commitment to the efferent limb of the apoptotic pathway. Apoptosis was confirmed by a significant increase in the percentage of neurons undergoing apoptosis at 1 month (8%), 3 months (7%), and 12 months (11%). These findings support the concept that oxidative stress leads to oxidative injury of DRG neurons, with mitochondrium as a specific target, leading to impaired mitochondrial function and apoptosis, manifested clinically as a predominantly sensory neuropathy. Diabetes 52: [165][166][167][168][169][170][171] 2003

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“…Permeable capillaries near to the spinal cord are found in the dorsal root ganglion and the dorsal and ventral roots (Olsson, 1968;Jacobs et aI., 1976;Juhler et aI., 1985). The radicular arteries mental allergic encephalomyelitis (EAE).…”

Section: Distribution Of Lesionsmentioning

confidence: 99%

A Spatial Analysis of the Blood—Brain Barrier Damage in Experimental Allergic Encephalomyelitis

Juhler¹,

Blasberg²,

Fenstermacher

et al. 1985

J Cereb Blood Flow Metab

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Experimental allergic encephalomyelitis was induced in young male Lewis rats. Following the development of neurological signs, the local distribution of perivascular inflammatory cellular infiltrates and the local blood-to-tissue transfer constants ( K1) of α-aminoisobutyric acid (AIB) were determined, and these results were compared. Perivascular infiltrative lesions were generally found near areas of the CNS that normally lack an effective blood–brain barrier (BBB) such as the choroid plexus and the entry zones of the cranial and spinal nerve roots. This distribution pattern indicates that the entry of the causative agent into CNS tissue may be by way of the permeable microvessels of these structures. In tissue around inflamed veins, the mean transfer constant was slightly but significantly increased (2.8 ± 1.5 μl g−1 min−1) compared with uninvolved regions (0.9 ± 0.2 μl g−1 min−1) and similar areas in control animals (0.9 ± 0.3 μl g−1 min−1). Analysis of the autoradiographic method of determining transfer constants suggested that the AIB influx rate in the lesion areas may actually be manyfold larger than measured, that BBB permeability may be greatly increased at such sites, and that the areas of lymphocytic infiltration and increased K values may be virtually identical.

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Topographical differences in the vascular permeability of the peripheral nervous system

Cited by 225 publications

References 24 publications

Mesaxonal membrane junction of myelinated nerve in the central and peripheral nervous system.

Mesaxonal membrane junction of myelinated nerve in the central and peripheral nervous system.

Oxidative Injury and Apoptosis of Dorsal Root Ganglion Neurons in Chronic Experimental Diabetic Neuropathy

A Spatial Analysis of the Blood—Brain Barrier Damage in Experimental Allergic Encephalomyelitis

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