Mesaxonal membrane junction of myelinated nerve in the central and peripheral nervous system.

Inokuchi, Tetsuo; Higashi, Ryuhei

doi:10.1679/aohc1950.43.221

Cited by 7 publications

(2 citation statements)

References 35 publications

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“…The localization of the TJ components claudin and ZO-1 in non-compact myelin is in accordance with previous ultrastructural studies that showed TJ strands in the inner and outer mesaxons, paranodal loops, and Schmidt-Lanterman incisures (Inokuchi and Higashi 1980; Shinowara et al 1980; Stolinski and Breathnach 1982). Similarly, adherens junctions containing E-cadherin have been shown in the same specific non-compact myelin areas (Fannon et al 1995; Poliak et al 2002).…”

Section: Discussionsupporting

confidence: 92%

Tight Junction Proteins in Human Schwann Cell Autotypic Junctions

Alanne

Pummi

Heape

et al. 2009

J Histochem Cytochem.

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(AMH) S U M M A R Y Tight junctions (TJs) form physical barriers in various tissues and regulate paracellular transport of ions, water, and molecules. Myelinating Schwann cells form highly organized structures, including compact myelin, nodes of Ranvier, paranodal regions, Schmidt-Lanterman incisures, periaxonal cytoplasmic collars, and mesaxons. Autotypic TJs are formed in non-compacted myelin compartments between adjacent membrane lamellae of the same Schwann cell. Using indirect immunofluorescence and RT-PCR, we analyzed the expression of adherens junction (E-cadherin) and TJ [claudins, zonula occludens (ZO)-1, occludin] components in human peripheral nerve endoneurium, showing clear differences with published rodent profiles. Adult nerve paranodal regions contained E-cadherin, claudin-1, claudin-2, and ZO-1. Schmidt-Lanterman incisures contained E-cadherin, claudin-1, claudin-2, claudin-3, claudin-5, ZO-1, and occludin. Mesaxons contained E-cadherin, claudin-1, claudin-2, claudin-3, ZO-1, and occludin. None of the proteins studied were associated with nodal inter-Schwann cell junctions. Fetal nerve expression of claudin-1, claudin-3, ZO-1, and occludin was predominantly punctate, with a mesaxonal labeling pattern, but paranodal (ZO-1, claudin-3) and Schmidt-Lanterman incisure (claudins-1 and -3) expression profiles typical of compact myelin were visible by gestational week 37. The clear differences observed between human and published rodent nerve profiles emphasize the importance of human studies when translating the results of animal models to human diseases. PERIPHERAL AXONS are isolated from the surrounding non-nervous tissues by a triple layer of collagen-based connective tissue, including the outermost epineurial layer, that surrounds the whole nerve, the perineurium, which surrounds nerve fascicles, and the innermost endoneurial layer that surrounds individual nerve fibers, and by a Schwann cell sheath. In adults, the Schwann cells form either a myelin sheath or an amyelin sheath. Myelinating Schwann cells wrap around the axon, forming highly organized, compacted, and noncompacted, multilamellar membrane structures. The non-compact structures include the paranodal loop regions, the Schmidt-Lanterman incisures, the periaxonal cytoplasmic collar, and the inner and outer mesaxons. At the nodes of Ranvier, interdigitations of the plasma membranes of adjacent Schwann cells assure the continuity of the Schwann cell sheath along the whole length of the axon, while a continuous, Schwann cell-derived basal lamina forms a permeable boundary between the endoneurial connective tissue layer and the Schwann cell myelin sheath (Thomas 1963).Perineurial cells of the perineurium form a selective diffusion barrier between the endoneurium and the epineurium (Thomas 1963;Jaakkola et al. 1993;Pummi et al. 2004), and we have previously shown that the tight junction (TJ) proteins zonula occludens (ZO)-1, occludin, claudin-1, and claudin-3 all contribute to the formation of this perineurial diffusion barrier in human Cor...

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Section: Discussionsupporting

confidence: 92%

Tight Junction Proteins in Human Schwann Cell Autotypic Junctions

Alanne

Pummi

Heape

et al. 2009

J Histochem Cytochem.

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“…Subsequently, a concept of myelinic tight junction was proposed for the rows of particles located in the freeze-fractured myelin lamellae in the central myelin sheath (DERMIETZEL,1974;REALE et al, 1975) and the peripheral myelin sheath (INOKucHI and HIGASHI, 1980;SHINOWARA et al, 1980). According to their location in the myelin sheath, the myelinic tight junctions were classified into two kinds, marginal and interlamellar tight junctions.…”

mentioning

confidence: 99%

Ultrastructure of the radial components of the mouse optic nerve and its changes during wallerian degeneration.

Honjin

Yamashita

Higashimoto

et al. 1985

Arch. Histol. Jap., Arch. Histol. Jpn

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Summary. Radial components of the optic nerve of the mouse were studied by using thin sections and freeze-fracture replicas. The investigations were performed on normal optic nerves, as well as on those undergoing Wallerian degeneration following eyeball enucleation. Normal radial components in thin sections were observed as a series of light lines composed of small electron-lucent dots situated in the interperiod lines across the myelin sheath. They are frequently found in those parts of the myelin sheath lying near the outer and inner processes of the oligodendroglia.Radial components in freeze-fracture replica were observed as a parallel array of many ridges composed of a row of particles.The particles of radial components located in the deeper part of the myelin sheath lose their linear arrangement and fall into disorder in a relatively early post-operative period.

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M

Krstić¹

1984

Illustrated Encyclopedia of Human Histology

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Mesaxonal membrane junction of myelinated nerve in the central and peripheral nervous system.

Cited by 7 publications

References 35 publications

Tight Junction Proteins in Human Schwann Cell Autotypic Junctions

Tight Junction Proteins in Human Schwann Cell Autotypic Junctions

Ultrastructure of the radial components of the mouse optic nerve and its changes during wallerian degeneration.

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