Topographic variation of choroidal and retinal thicknesses at the macula in healthy adults

Tan, Colin S.; Cheong, Kai Xiong; Lim, Louis W.; Li, Kelvin Z.

doi:10.1136/bjophthalmol-2013-304000

Cited by 114 publications

(89 citation statements)

References 24 publications

(23 reference statements)

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“…The choroid plays an integral role in the metabolic support of the retinal pigment epithelium (RPE), optic nerve, and outer retina; normal choroidal vasculature is essential for appropriate functioning of the retina (11,12) . Compromised choroidal blood flow may result in dysfunctioning of the photoreceptor and insufficient removal of me tabolites generated by RPE cells, resulting in an accumulation of waste at Bruch's membrane (13) .…”

Section: Discussionmentioning

confidence: 99%

“…Anti-vascular endothelial growth factor (anti-VEGF) drugs are widely used in the treatment of diabetic macular edema (DME); this is supported by an extensive body of literature, demonstrating substantial improvements in visual and anatomic outcomes (4)(5)(6)(7)(8)(9)(10) . The choroid is a vascularized tissue that plays a vital role in providing metabolic support to the outer retina, including the photoreceptors and prelaminar portion of the optic nerve head (11,12) . Abnormal choroidal blood volume and compromised flow may result in dysfunctioning of the photoreceptor and mortality (13) .…”

Section: Introductionmentioning

confidence: 99%

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Effect of intravitreal anti-VEGF on choroidal thickness in patients with diabetic macular edema using spectral domain OCT

Kniggendorf¹,

Novais²,

Kniggendorf³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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Approved by the following research ethics committee: UNIFESP (#1.093.853). ABSTRACTPurpose: To evaluate choroidal thickness (CT) using spectral domain optical coherence tomography (SD-OCT) imaging at baseline and 6 months after intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment in patients with diabetic macular edema (DME). Methods: A retrospective chart review was performed to identify patients with DME who underwent intravitreal injection of anti-VEGF (bevacizumab or ranibizumab) in a pro re nata (PRN) regimen. Subfoveal choroidal thickness was compared between values obtained at baseline and at 6-month follow-up visits. Results: Thirty-nine eyes (15 females, 24 males) from 39 patients were enrolled (mean age, 62.43 ± 8.7 years; range, 44-79 years). Twenty-three and 16 eyes were treated with ranibizumab and bevacizumab respectively. The mean number of anti-VEGF injections was 2.28 ± 1.27 (range, 1-5). Mean nasal, subfoveal, and temporal choroidal thickness (CT) measurements at baseline were 234.10 ± 8.63 μm, 246.89 ± 8.94 μm, and 238.12 ± 8.20 μm, respectively, and those at 6 months post-treatment were 210.46 ± 8.00 μm, 215.66 ± 8.29 μm, and 212.43 ± 8.14 μm, respectively. Significant differences in CT were observed between baseline and the 6-month follow-up at all measured points (p=0.0327). Conclusions: Over a 6-month period, the use of intravitreal anti-VEGF was associated with significant thinning of the choroid in patients with DME. The clinical significance of a thinner choroid in DME is currently unknown; however, it may contribute to long-term adverse effects on choroidal and retinal function, representing an area requiring future investigation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of intravitreal anti-VEGF on choroidal thickness in patients with diabetic macular edema using spectral domain OCT

Kniggendorf¹,

Novais²,

Kniggendorf³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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“…However, it was not possible to collect data from axial length, which is known to influence choroidal thickness [12,19]. In order to minimize this bias, we selected patients with a known ametropia below 4 dioptres to exclude the set of patients outside the normal range of axial length.…”

Section: Discussionmentioning

confidence: 99%

Choroidal Thickness of the Papillomacular Region in Young Healthy Individuals

et al. 2014

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Purpose: To characterize the choroidal thickness of the papillomacular region in young healthy individuals using spectral-domain optical coherence tomography (SD-OCT). Methods: Papillary and macular SD-OCT scans were obtained using an enhanced depth imaging mode. Digital retinography was used to assess any overlapping areas and to determine the papillomacular region. Spearman's correlations were used to explore the relationship between the different regional choroidal thicknesses. Results: Sixty-three volunteers aged 21.6 ± 1.1 years were included. There was a significant asymmetry in choroidal thickness throughout the 10-mm length model (p < 0.001). While the choroid was shown to thicken as the distance from the optic disc increased (p < 0.001), each of the 500-µm blocks of the papillomacular region were significantly thinner than their nasal counterparts (p < 0.02 in all pairwise comparisons). Conclusion: In young healthy individuals, the choroid under the papillomacular region appears to be thinner than in other areas. These differences could relate to specificities of the retina overlying this region.

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“…Significant topographic variations of choroidal and retinal thicknesses at the macula have been reported. 2,3 Some regions of the choroid may be more sensitive to endocrinological changes in acromegaly.…”

Section: Sir Chorio-retinal Thickness Measurements In Patients With mentioning

confidence: 99%

Regarding ‘transient visual loss due to reversible ‘pending’ central retinal artery occlusion in occult giant cell arteritis’

Alwitry

2015

Eye

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Topographic variation of choroidal and retinal thicknesses at the macula in healthy adults

Abstract: There is significant topographic variation of choroidal and RTs at different regions of the macula, with progressive change of choroidal thickness in all sectors based on the refractive status of the eye.

Cited by 114 publications

References 24 publications

Effect of intravitreal anti-VEGF on choroidal thickness in patients with diabetic macular edema using spectral domain OCT

Effect of intravitreal anti-VEGF on choroidal thickness in patients with diabetic macular edema using spectral domain OCT

Choroidal Thickness of the Papillomacular Region in Young Healthy Individuals

Regarding ‘transient visual loss due to reversible ‘pending’ central retinal artery occlusion in occult giant cell arteritis’

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