Topographic transcriptomics of the nucleus accumbens shell: Identification and validation of fatty acid binding protein 5 as target for cocaine addiction

Crofton, Elizabeth J.; Nenov, Miroslav N.; Zhang, Yafang; Tapia, Cynthia M.; Donnelly, Joseph E.; Koshy, Shyny; Laezza, Fernanda; Green, Thomas A.

doi:10.1016/j.neuropharm.2020.108398

Cited by 22 publications

(16 citation statements)

References 52 publications

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“…Additionally, prior research shows that manipulations of retinoic acid signaling alter drug taking and seeking (Crofton et al, 2021;Zhang et al, 2016), thus we hypothesized that overexpression of retinoic acid receptor beta in the nucleus accumbens shell would alter FN and/or fentanyl taking/seeking, but this hypothesis was not supported by the data.…”

Section: Introductionmentioning

confidence: 80%

“…The shNAc was targeted as the repetitive activation of the shNAc by drugs of abuse results in strengthening of stimulus-reward and stimulus-response associations ( Di Chiara, 1998 , 2002 ; Di Chiara et al, 2004 ). Additionally, retinoic acid signaling is the most enhanced shNAc pathway with RARβ being one transcript that was identified as a strong target ( Zhang et al, 2016 ; Crofton et al, 2021 ). It is also suggested that the shNAc plays a role in goal-oriented behavior ( Mannella et al, 2013 ), and it is generally understood that the experience of frustration occurs when the goal is denied or made more difficult to achieve.…”

Section: Methodsmentioning

confidence: 99%

“…Additionally, retinoic acid signaling is the most enhanced shNAc pathway with RARβ being one transcript that was identified as a strong target (Crofton et al, 2021;Zhang et al, 2016). It is also suggested that the shNAc plays a role in goal-oriented behavior (Mannella, Gurney, and Baldassarre, 2013); and it is generally understood that the experience of frustration occurs when the goal is denied or made more difficult to achieve.…”

Section: Fentanyl Operant Respondingmentioning

confidence: 99%

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Individual Differences in Frustrative Nonreward Behavior for Sucrose in Rats Predict Motivation for Fentanyl under Progressive Ratio

Vasquez

Shah

et al. 2021

eNeuro

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Section: Introductionmentioning

confidence: 80%

Section: Methodsmentioning

confidence: 99%

Section: Fentanyl Operant Respondingmentioning

confidence: 99%

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Individual Differences in Frustrative Nonreward Behavior for Sucrose in Rats Predict Motivation for Fentanyl under Progressive Ratio

Vasquez

Shah

et al. 2021

eNeuro

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“…FABP 5/7 double knockout mice exhibit similar acquisition of cocaine-induced CPP relative to WT mice, whereas these mice do not exhibit stress-induced preference and show decreased levels of serum corticosterone under stress relative to WT mice [ 164 ]. Recent studies have reported that FABP5 knockdown in the adult rat NAc shell with RNA interference via adeno-associated viral vector attenuates cocaine self-administration and modulates the excitability of MSNs in the NAc shell [ 165 ]. FABP3 binds to ω-6 PUFAs [ 166 ], forms a complex, and colocalizes with D2R in the glutamatergic terminals and cholinergic interneurons in the dorsal striatum of mice [ 167 ].…”

Section: Involvement Of Lcpufas and The Novel Target Fabp3 In Nicomentioning

confidence: 99%

The Role of CaMKII and ERK Signaling in Addiction

Jia

Kawahata

Cheng

et al. 2021

IJMS

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Nicotine is the predominant addictive compound of tobacco and causes the acquisition of dependence through its interactions with nicotinic acetylcholine receptors and various neurotransmitter releases in the central nervous system. The Ca2+/calmodulin-dependent protein kinase II (CaMKII) and extracellular signal-regulated kinase (ERK) play a pivotal role in synaptic plasticity in the hippocampus. CaMKII is involved in long-term potentiation induction, which underlies the consolidation of learning and memory; however, the roles of CaMKII in nicotine and other psychostimulant-induced addiction still require further investigation. This article reviews the molecular mechanisms and crucial roles of CaMKII and ERK in nicotine and other stimulant drug-induced addiction. We also discuss dopamine (DA) receptor signaling involved in nicotine-induced addiction in the brain reward circuitry. In the last section, we introduce the association of polyunsaturated fatty acids and cellular chaperones of fatty acid-binding protein 3 in the context of nicotine-induced addiction in the mouse nucleus accumbens and provide a novel target for the treatment of drug abuse affecting dopaminergic systems.

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“…Thinking from the amygdala (Wang et al, 2018) and the cingulate (Leech & Smallwood, 2019) causes anger and stress resulting in poor health, decreased productivity, and disconnection from the community. Thinking from the accumbens results in addiction (Crofton et al, 2020). This traditional consideration of the brain as the center of thought needs to be reexamined and expanded.…”

Section: Four Locations Of Thought In the Eplerian Philosophymentioning

confidence: 99%

Eplerian Philosophy for a New Way of Life

Epler¹

2021

OJPP

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Eplerian philosophy is defined as: "Know who you are moment by moment." The purpose of this article is to show that the philosophy is based on scientific research, the relevance and implications, and how to apply the fundamental principles. This means knowing where you're thinking from and that's who you are. There are four locations you can think from: the head brain, the heart, the belly brain, and the mind. These are independent locations with no interconnection among them, and you can only think from one location at a time. The function of the head brain is to improve our financial and social lives daily by implementing the actions from the heart, the belly brain, and the mind. The feelings from the head brain include anger, stress from self-thinking, and pleasure from the addiction center. Application of the Eplerian philosophy is to bypass the head brain amygdala anger center, cingulate stress center, and the accumbens addiction center by thinking from the heart and the mind. The function of the heart is to keep itself healthy, and the feelings include kindness, empathy, gratitude, and giving. The function of the belly brain is risk-benefit management, and the feeling is fear. The function of the mind is creativity, and the feelings include total calmness and unconditional love. Thinking from the head is unhealthy, unproductive, and causes stress. Thinking from the belly brain keeps us grounded. Thinking from the heart and the mind is healthy and feels good. This is a new way of life for extraordinary living.

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Topographic transcriptomics of the nucleus accumbens shell: Identification and validation of fatty acid binding protein 5 as target for cocaine addiction

Cited by 22 publications

References 52 publications

Individual Differences in Frustrative Nonreward Behavior for Sucrose in Rats Predict Motivation for Fentanyl under Progressive Ratio

Individual Differences in Frustrative Nonreward Behavior for Sucrose in Rats Predict Motivation for Fentanyl under Progressive Ratio

The Role of CaMKII and ERK Signaling in Addiction

Eplerian Philosophy for a New Way of Life

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