The Role of CaMKII and ERK Signaling in Addiction

Jia, Wenbin; Kawahata, Ichiro; Cheng, An; Fukunaga, Kohji

doi:10.3390/ijms22063189

Cited by 22 publications

(22 citation statements)

References 171 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To further elucidate the downstream intracellular pathways involved in the effects of CB1R blockade, we used immunoblotting to study the expression of ERK and phosphorylated ERK (p-ERK), key regulators of synaptic plasticity [ 27 ]. In addition, activation of CB1R triggers mammalian target of rapamycin (mTOR) signalling in the hippocampus [ 28 ]; we quantified phosphorylated (active) mTOR in both saline- and cocaine-treated mice.…”

Section: Resultsmentioning

confidence: 99%

Endocannabinoids regulate cocaine-associated memory through brain AEA–CB1R signalling activation

Chen

Zhou

et al. 2022

Molecular Metabolism

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Endocannabinoids regulate cocaine-associated memory through brain AEA–CB1R signalling activation

Chen

Zhou

et al. 2022

Molecular Metabolism

View full text Add to dashboard Cite

“…Fortunately, our data suggest that the inhibitory effect of U0126 depends on the BLA, which is consistent with Wells et al ( 2013 ) study that ERK in the BLA is critical for context-response–cocaine reconsolidation (Wells et al, 2013 ). Consolidation of new drug-related memories is ERK dependent (Lu et al, 2006 ; Jia et al, 2021 ). Similar findings have been reported that activation of the ERK pathway results in long-term changes in synaptic activity that underlie the consolidation of new memories (Schafe et al, 2000 ; Rodrigues et al, 2004 ; Feld et al, 2005 ; Lai et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Extracellular signal-regulated kinase in the basolateral amygdala is required for reconsolidation of heroin-associated memory

Zhang³

et al. 2022

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Reconsolidation of heroin-associated memory is an independent memory process that occurs following retrieval, which is essential for the sustained capacity of an associative drug stimulus to precipitate heroin-seeking. Extracellular signal-regulated kinase (ERK) in the basolateral amygdala (BLA) mediates the reconsolidation of drug memory. In the present study, we utilized a rat model of drug craving and relapse to verify the hypothesis that the reconsolidation of heroin-associated memory requires ERK in an instrumental heroin-seeking behavior, focusing on the BLA brain region, which is crucial for synaptic plasticity and memory processes. We found that bilateral intra-BLA infusions of U0126 (1 μg/0.5 μl), an ERK inhibitor, immediately after retrieving heroin-associated memory significantly reduced cue-induced and drug-induced reinstatement and spontaneous recovery of heroin-seeking compared to the vehicle. Furthermore, this inhibitory effect was related to the characteristic of reconsolidation. Conversely, no effect was observed on the heroin-seeking behavior when the intra-BLA infusion of U0126 was administered 6 h after the heroin-associated memory retrieval or without memory retrieval. Together, these data suggest that disrupting the reconsolidation of heroin-associated memory via an ERK inhibitor may serve as a promising option for treating relapse in opiate addicts.

show abstract

“… Nicotine elicits the release of neurotransmitters such as norepinephrine, dopamine, acetylcholine, serotonin, glutamate, and GABA . It initiates its biological function by activating the nicotinic acetylcholine receptor through binding with ligand-gated ion channels Oxycodone is a highly selective full agonist of the MOR but has a low affinity for the δ-opioid and the κ-opioid receptors .…”

Section: Alkaloidsmentioning

confidence: 99%

Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

et al. 2022

View full text Add to dashboard Cite

The presence of positron emission tomography (PET) centers at most major hospitals worldwide, along with the improvement of PET scanner sensitivity and the introduction of total body PET systems, has increased the interest in the PET tracer development using the short-lived radionuclides carbon-11. In the last few decades, methodological improvements and fully automated modules have allowed the development of carbon-11 tracers for clinical use. Radiolabeling natural compounds with carbon-11 by substituting one of the backbone carbons with the radionuclide has provided important information on the biochemistry of the authentic compounds and increased the understanding of their in vivo behavior in healthy and diseased states. The number of endogenous and natural compounds essential for human life is staggering, ranging from simple alcohols to vitamins and peptides. This review collates all the carbon-11 radiolabeled endogenous and natural exogenous compounds synthesised to date, including essential information on their radiochemistry methodologies and preclinical and clinical studies in healthy subjects.

show abstract

The Role of CaMKII and ERK Signaling in Addiction

Cited by 22 publications

References 171 publications

Endocannabinoids regulate cocaine-associated memory through brain AEA–CB1R signalling activation

Endocannabinoids regulate cocaine-associated memory through brain AEA–CB1R signalling activation

Extracellular signal-regulated kinase in the basolateral amygdala is required for reconsolidation of heroin-associated memory

Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

Contact Info

Product

Resources

About