Topographic Differences of 1H-NMR Relaxation Times (T13 T2) in the Normal Intervertebral Disc and Its Relationship to Water Content

Chatani, Kenichi; Kusaka, Yoshiaki; Mifune, Teturou; Nishikawa, Hiroyasu

doi:10.1097/00007632-199311000-00022

Cited by 53 publications

(39 citation statements)

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“…The results of the present study support the hypothesis that water is pressed out of the nucleus pulposus (decrease of T2 in the NP and the intermediate areas) and moves to the rim (increase of T2 in the AF). (19), who found T2 values between 22 ms in the AF and 51 ms in the NP. This finding may be due to a slightly different magnetic field strength of 1.41T and due to a different sequence technique: In our human study, a multi-echo sequence was used, which is less sensitive to diffusion effects than a single spin echo approach.…”

Section: Discussionmentioning

confidence: 98%

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T2‐ and diffusion‐maps reveal diurnal changes of intervertebral disc composition: An in vivo MRI study at 1.5 Tesla

Ludescher¹,

Effelsberg

Martirosian³

et al. 2008

Magnetic Resonance Imaging

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Purpose: To investigate the lumbar intervertebral discs (IVDs) by MRI in the morning and evening after a diurnal load cycle. Changes in MR characteristics (T2-weighted imaging, T2-and apparent diffusion coefficient [ADC] -mapping) during the course of the day were visualized and analyzed visually and quantitatively. The length of the lumbar spine was measured in between the lower anterior edge of Th12 and the upper anterior edge of S1. T2 changes and diffusion characteristics of the vertebral disc tissue were investigated with a higher spatial resolution than in former studies. Materials and Methods:In six males, lumbar IVDs were investigated in the morning and evening. T2-maps and ADC maps were generated. Data were analyzed by selecting regions of interest (ROI) in the annulus fibrosus (AF), nucleus pulposus (NP), and an intermediate area.Results: From morning to evening, T2 decreased in the center of the NP (Ϫ7.9%; P ϭ 0.001) and the intermediate voxels (Ϫ6.4%; P Ͻ 0.0005). T2 increased (8.5%; P Ͻ 0.048) in the AF. ADC decreased in the AF (Ϫ5.2%; P ϭ 0.007) and the intermediate ROIs (Ϫ2.2%; P ϭ 0.004). There was no significant change of ADC in the NP (Ϫ1.6%; P ϭ 0.242).Conclusion: T2 and diffusion (ADC) changes of IVDs in humans were investigated with a spatial differentiation between NP and AF. T2 and ADC turned out to be sensitive parameters in investigating changes in the MR characteristics of the IVD matrix during a day. Highly resolved MR imaging and parameter mapping is expected to be an interesting tool in characterizing structural changes in the vertebral disc architecture in an early stage of degeneration.

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Section: Discussionmentioning

confidence: 98%

“…For this reason, the absolute T2 values cannot be compared absolutely. In addition, it should be mentioned that bovine tail IVDs were measured in vitro by Chatani et al (19).…”

Section: Discussionmentioning

confidence: 99%

T2‐ and diffusion‐maps reveal diurnal changes of intervertebral disc composition: An in vivo MRI study at 1.5 Tesla

Ludescher¹,

Effelsberg

Martirosian³

et al. 2008

Magnetic Resonance Imaging

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“…a higher water content in the disc. Chatani et al (25) have shown that there are highly significant differences in both T 1 and T 2 relaxation times between the nucleus and the annulus. Using linear regression, they established a relationship between T 1 and water content in the nucleus and annulus, but the slope of the regression line between water content was significantly higher in the nucleus than the annulus.…”

Section: Mri Relaxation Time Measurementsmentioning

confidence: 99%

Magnetic resonance imaging and spectroscopy of the intervertebral disc

Majumdar

2006

NMR in Biomedicine

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Intervertebral disc disease is an emerging health concern and has a considerable negative effect on the economy and on society. MRI has a critical role in assessing the disc, but it is still a challenge to objectively correlate disc health and pain with images. In this paper, a review of MR disc imaging techniques including grading, relaxation time measurements, diffusion, and contrast perfusion is presented. In addition, high-resolution magic-angle spinning methods to correlate in vitro disc degeneration (with pain, etc) are discussed. With the potential for gaining morphological and biochemical information, MRI shows promise for quantitative assessment of disc health.

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“…8,[12][13][14] For further quantitative evaluation of IVDD based on the biochemical changes in disks, several MR imaging techniques have been developed. They include dynamic contrast MR imaging, 9 magnetization transfer imaging, 16 T1 measurement, 17 T2 measurement, niques aim to quantitatively detect early degenerative changes in the matrix content of intervertebral disks. The lumbar intervertebral disk is the largest avascular structure in a human body.…”

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confidence: 99%

MR Imaging Assessment of Lumbar Intervertebral Disk Degeneration and Age-Related Changes: Apparent Diffusion Coefficient versus T2 Quantitation

Niu¹,

Yang²,

Wang³

et al. 2011

AJNR Am J Neuroradiol

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Topographic Differences of 1H-NMR Relaxation Times (T13 T2) in the Normal Intervertebral Disc and Its Relationship to Water Content

Cited by 53 publications

References 0 publications

T2‐ and diffusion‐maps reveal diurnal changes of intervertebral disc composition: An in vivo MRI study at 1.5 Tesla

T2‐ and diffusion‐maps reveal diurnal changes of intervertebral disc composition: An in vivo MRI study at 1.5 Tesla

Magnetic resonance imaging and spectroscopy of the intervertebral disc

MR Imaging Assessment of Lumbar Intervertebral Disk Degeneration and Age-Related Changes: Apparent Diffusion Coefficient versus T2 Quantitation

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