Topographic Analysis of the Choriocapillaris in Intermediate Age-related Macular Degeneration

Borrelli, Enrico; Shi, Yue; Uji, Akihito; Balasubramanian, Siva; Nassisi, Marco; Sarraf, David; Sadda, Srinivas R

doi:10.1016/j.ajo.2018.08.014

Cited by 117 publications

(107 citation statements)

References 27 publications

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“…Moreover, a higher average CC signal void size was reported in eyes with early and iAMD and type 3 neovascularization in the fellow eye versus early and iAMD and type 1 or 2 neovascularization in the fellow eye (Borrelli et al. ,b,c). It is clearly established that patients with nAMD in one eye have a higher risk of developing nAMD in the fellow eye, therefore, these data may support the hypothesis that CC impairment could drive the development of neovascular form of AMD.…”

Section: Discussionmentioning

confidence: 98%

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Quantitative choriocapillaris evaluation in intermediate age‐related macular degeneration by swept‐source optical coherence tomography angiography

Vujosevic

Toma

Muraca

et al. 2019

Acta Ophthalmologica

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Purpose: To investigate choriocapillaris (CC) perfusion, by evaluating flow voids (FV), in eyes with intermediate age-related macular degeneration (iAMD) using swept-source optical coherence tomography angiography (SS-OCT-A). Methods: Patients with bilateral or unilateral iAMD and normal controls underwent SS-OCT and OCT-A examination. Choriocapillaris (CC) FVs were quantitatively assessed on OCT-A images using MATLAB (version 2017b; MathWorks, Natick, MA, USA), after a preprocessing aimed at compensating for CC attenuation artefacts. Three different thresholds [1 standard deviation (SD), 1.25 SD and 1.5 SD] were applied. Final FV percentage (FV%) was calculated as the ratio between area with absent flow and total scanned area. Results: Of 41 patients with iAMD and 16 normal subjects enrolled in the study, 39 eyes (39 patients) with iAMD and all 16 normal eyes (16 control subjects) were included in the final analysis. Mean FV% (1 SD) was 13.45 AE 0.66 in controls, 14.19 AE 1.23 in bilateral iAMD and 14.21 AE 0.99 in unilateral iAMD (p = 0.03, for difference between controls and bilateral iAMD). Mean FV% (1.25 SD) was 6.55 AE 0.65 in controls, 7.33 AE 1.4 in bilateral iAMD and 7.06 AE 1.4 in unilateral iAMD (p = 0.048, for difference between controls and bilateral iAMD). Mean FV% (1.5 SD) was 2.71 AE 0.82 in controls, 2.55 AE 1.12 in bilateral iAMD and 3.25 AE 1.17 in unilateral iAMD (p = 0.038, for difference between bilateral and unilateral iAMD). Conclusion: A significantly higher FV% was found in patients with iAMD versus controls. A higher trend in FV% was found in unilateral iAMD (with neovascular AMD in the fellow eye) versus bilateral iAMD, when applying the lowest threshold. Further, larger and longitudinal studies are needed to confirm this data.

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Section: Discussionmentioning

confidence: 98%

“…Thus, the reduction in CC flow, described in patients with iAMD, may affect photoreceptor structure and function (Borrelli et al. ), leading to impaired macular function. Nesper et al.…”

Section: Discussionmentioning

confidence: 99%

Quantitative choriocapillaris evaluation in intermediate age‐related macular degeneration by swept‐source optical coherence tomography angiography

Vujosevic

Toma

Muraca

et al. 2019

Acta Ophthalmologica

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“…CC flow density (CFD) detected using OCTA have emerged as a potential metric to evaluate the inner choroid vasculature through fast noninvasive imaging and have therefore been used extensively for various retinal diseases [12][13][14][15]. However, PCV and nAMD in their fellow eyes have not been compared using OCTA.…”

Section: Introductionmentioning

confidence: 99%

Comparison of choriocapillary flow density between fellow eyes of polypoidal choroidal vasculopathy and neovascular age-related macular degeneration

Luo

Zhao

et al. 2020

BMC Ophthalmol

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Background: To compare the choriocapillary flow density (CFD) among the fellow eyes of polypoidal choroidal vasculopathy (PCV), neovascular age-related macular degeneration (nAMD), and healthy controls using spectraldomain optical coherence angiography tomography (SD-OCTA). Methods: This is a cross-sectional study that includes the fellow eyes of 38 patients with unilateral PCV, 36 patients with unilateral nAMD, and 36 eyes from 36 healthy volunteers. The PCV group was further classified into polypoidal CNV (P-CNV) and typical PCV (T-PCV) for subgroup analysis. The age, subfoveal choroidal thickness (SFCT), Age-Related Eye Disease Study (AREDS) classification, and fellow eye diagnosis were acquired. All subjects underwent SD-OCTA with a 6.0-mm scan pattern. Circles with radius of 1.00, 1.50, and 3.00 mm were manually selected in the choriocapillaris (CC) slab, and the CFD was calculated as the percentage of the flow area to the whole selected area as CFD-1.00, 1.50, and 3.00, respectively. Univariate and multivariate analysis were performed to study the correlation between the aforementioned factors with CFD.

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“…Several strategies have been evolved to limit projection artifacts [10][11][12]. One of the easiest strategies to limit projection artifacts is to subtract the SCP OCTA en face image from the deeper layers [10,11,[13][14][15].…”

Section: Different Artifacts May Alter the Visualization Of Octa Imagesmentioning

confidence: 99%

Pearls and Pitfalls of Optical Coherence Tomography Angiography Imaging: A Review

et al. 2019

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Optical coherence tomography angiography (OCTA) has significantly expanded our knowledge of the ocular vasculature. Furthermore, this imaging modality has been widely adopted to investigate different ocular and systemic diseases. In this review, a discussion of the fundamental principles of OCTA is followed by the application of this imaging modality to study the retinal and choroidal vessels. A proper comprehension of this imaging modality is essential for the interpretation of OCTA imaging applications in retinal and choroidal disorders.

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Topographic Analysis of the Choriocapillaris in Intermediate Age-related Macular Degeneration

Cited by 117 publications

References 27 publications

Quantitative choriocapillaris evaluation in intermediate age‐related macular degeneration by swept‐source optical coherence tomography angiography

Quantitative choriocapillaris evaluation in intermediate age‐related macular degeneration by swept‐source optical coherence tomography angiography

Comparison of choriocapillary flow density between fellow eyes of polypoidal choroidal vasculopathy and neovascular age-related macular degeneration

Pearls and Pitfalls of Optical Coherence Tomography Angiography Imaging: A Review

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