Topographic analysis of retinal and choroidal microvasculature according to diabetic retinopathy severity using optical coherence tomography angiography

Ryu, Gahyung; Kim, Inhye; Sagong, Min

doi:10.1007/s00417-020-04785-7

Cited by 16 publications

(13 citation statements)

References 31 publications

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“…Choriocapillaris perfusion was decreased in DM patients even without retinopathy in studies using OCTA, indicating that decreased choriocapillaris perfusion may exist before clinically detectable DR [7,12,15,16]. In addition, the decrease in choriocapillaris VD was correlated with DR severity [7]. In the current study, choriocapillaris VD also decreased with increasing severity of DR. is finding is supported by other previous histopathological study results showing that a decrease in the alkaline phosphatase enzyme activity is associated with choriocapillaris loss in DM eyes [17,18].…”

Section: Discussionsupporting

confidence: 55%

“…An important finding in vasculature changes in DR using OCTA includes enlargement of the foveal avascular zone [ 4 ]. In addition, lower retinal vascular density (VD) in DR eyes has consistently been reported in previous studies [ 5 – 7 ]. Furthermore, retinal VD was shown associated with disease severity or visual function [ 6 ].…”

Section: Introductionsupporting

confidence: 64%

“…Age and DM duration were also associated with VD which is in agreement with findings from previous studies. Retinal VDs were associated with DR severity, older age, higher HbA1c level, and the presence of DME in previous studies [7,10]. In the present study, eyes with DME were excluded because DME can affect VDs as well as causing inaccurate measurement of VD.…”

Section: Discussionmentioning

confidence: 79%

“…A significant association of DR with retinal, SVC, and DVC VDs has been reported in many previous studies and decreases in vessel densities in DR have been suggested [7,11,12]. Because the retina has nonanastomotic end arteries, the pathophysiology of DM affects retinal vessels [13,14].…”

Section: Discussionmentioning

confidence: 81%

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Discordance in Retinal and Choroidal Vascular Densities in Patients with Type 2 Diabetes Mellitus on Optical Coherence Tomography Angiography

Kang

Song

et al. 2021

Journal of Ophthalmology

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Purpose. In the present study, the retinal and choroidal vascular densities (VDs) in type 2 diabetes mellitus (DM) patients were analyzed using optical coherence tomography angiography (OCTA). Methods. The study included 282 eyes of 152 patients with type 2 DM (114 without retinopathy, 79 nonproliferative diabetic retinopathy (NPDR), 48 severe NPDR, and 41 proliferative diabetic retinopathy (PDR) eyes). The superficial and deep retinal vessel, choriocapillaris, and choroidal VDs were measured using a binarization method on OCTA images. VDs were compared based on retinopathy severity. Correlations among densities were analyzed. Results. Retinal and choriocapillaris VDs were lower in PDR than in NPDR (all P < 0.05 ). Correlation analysis showed significant positive correlations among densities of superficial and deep retinal vessels and choriocapillaris (all P < 0.001 ). Choroidal VD showed a negative correlation with superficial and deep retinal vessels and choriocapillaris (all P < 0.001 ). Retinal and choriocapillaris VDs showed a negative correlation with diabetic retinopathy (DR) grade (all P < 0.001 ); however, the choroidal VD showed a weak positive correlation ( P = 0.030 ). Conclusion. Choroidal VD increased as retinal and choriocapillaris VDs decreased, indicating that the outer layer of the choroid is less affected by DR severity and VD of larger choroidal vessels may even be increased as a compensatory mechanism for decreased retinal and choriocapillaris VDs in type 2 DM patients.

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Section: Discussionsupporting

confidence: 55%

Section: Introductionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 81%

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Discordance in Retinal and Choroidal Vascular Densities in Patients with Type 2 Diabetes Mellitus on Optical Coherence Tomography Angiography

Kang

Song

et al. 2021

Journal of Ophthalmology

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“…When OCT angiography was used, a decreased vessel density was found in the superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris, while the foveal avascular zone (FAZ) increased [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of the Choroid and Its Relationship with the Outer Retina in Patients with Diabetes Mellitus Using Binarization Techniques Based on Spectral-Domain Optical Coherence Tomography

Damian

Román

Nicoară

2021

JCM

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(1) Background: We aimed to reveal the relationship between the choroid and the outer retina with optical coherence tomography (OCT) in patients with diabetes mellitus (DM) with mild or no diabetic retinopathy (DR) in order to find early biomarkers for progressing retinopathy. (2) Methods: We performed a prospective study including 61 eyes of patients with type 1 or type 2 DM and 36 eyes of healthy controls. All subjects were imaged with Spectralis OCT. The choroid was assesseed using enhanced depth imaging OCT (EDI-OCT). Binarization of subfoveal choroidal images was done with public domain software, ImageJ (version 1.53a; National Institutes of Health, Bethesda, Maryland, USA). (3) Results: Luminal area, stromal area and total choroidal area were significantly decreased in diabetic patients compared to control: 0.23 ± 0.07 vs. 0.28 ± 0.08, p = 0.012; 0.08 ± 0.03 vs. 0.10 ± 0.04, p = 0.026; 0.31 ± 0.09 vs. 0.38 ± 0.11, p = 0.008. The thickness of retinal pigment epithelium (RPE) correlated positively with the choroidal vascularity index (CVI). The correlations between outer nuclear layer (ONL), photoreceptors (PR) and foveal choroidal thickness (FChT) were moderately negative. (4) Conclusion: Thicker RPE and a thinner PR layer may be assigned the role of early biomarkers signaling the conversion time to progressing retinopathy.

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Optical coherence tomography angiography for quantitative microvascular assessment in diabetic retinopathy: inter-device and intra-device agreement and correlation with clinical staging

et al. 2022

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Topographic analysis of retinal and choroidal microvasculature according to diabetic retinopathy severity using optical coherence tomography angiography

Cited by 16 publications

References 31 publications

Discordance in Retinal and Choroidal Vascular Densities in Patients with Type 2 Diabetes Mellitus on Optical Coherence Tomography Angiography

Discordance in Retinal and Choroidal Vascular Densities in Patients with Type 2 Diabetes Mellitus on Optical Coherence Tomography Angiography

Analysis of the Choroid and Its Relationship with the Outer Retina in Patients with Diabetes Mellitus Using Binarization Techniques Based on Spectral-Domain Optical Coherence Tomography

Optical coherence tomography angiography for quantitative microvascular assessment in diabetic retinopathy: inter-device and intra-device agreement and correlation with clinical staging

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