Topographic Affinities of Hormone-Producing Cells in the Rat Anterior Pituitary Gland.

Noda, Takahiro; Kaidzu, Sachiko; Kikuchi, Motoshi; Yashiro, Takashi

doi:10.1267/ahc.34.313

Cited by 21 publications

(33 citation statements)

References 17 publications

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“…In contrast, all types of hormoneproducing cells appeared to express N-cadherin, although amounts of expression varied greatly from cell to cell and cell type to cell type. GH cells expressed Ncadherin most strongly, and this may be associated with the fact that GH cells tend to aggregate homogeneously compared with other hormone-producing cells (Noda et al, 2001). Connecting the differing amounts of N-cadherin expression with heterophilic cell affinities shown by hormone-producing cells in the anterior pituitary may yield interesting results.…”

Section: Discussionmentioning

confidence: 99%

“…Connecting the differing amounts of N-cadherin expression with heterophilic cell affinities shown by hormone-producing cells in the anterior pituitary may yield interesting results. Noda et al (2001) statistically showed cell affinities between GH and adrenocorticotrophic hormone (ACTH) cells and between luteinizing hormone (LH) and prolactin (PRL) cells. However, our triple-immunostaining observation of N-cadherin and pairs of hormone-producing cells found no relation between expression of N-cadherin and preferential heterophilic attachments of hormone-producing cells (data not shown).…”

Section: Discussionmentioning

confidence: 99%

“…These cells form a unique topography caused by homologous and heterologous affinities between cell types (Nakane, 1970;Horvath et al, 1977;Noda et al, 2001). Folliculo-stellate cells aggregate homologeously to form pseudofollicles.…”

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Distinctive localization of N‐ and E‐cadherins in rat anterior pituitary gland

et al. 2006

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In the rat anterior pituitary gland, folliculo-stellate cells aggregate preferably to form pseudofollicles, and each type of hormone-producing cell shows adhesive affinity with particular types of heterologous hormone-producing cells. Distribution of cadherin types in the rat anterior pituitary was examined immunohistochemically to clarify the unique cell arrangements caused by homologous and heterologous affinities among cells. N-and E-cadherins were detected continuously along cell membranes, while P-cadherin was not. N-and E-cadherins showed distinct isolation in localization, with N-cadherins localized in hormone-producing cells of distal and intermediate lobes in various amounts, and E-cadherins limited to folliculo-stellate cells and marginal layer cells facing the residual lumen of Rathke's pouch. A similar distribution of cadherins was observed in cell clusters of primary cultured anterior pituitary cells. These findings suggest that differential expression of cell adhesion molecules may be partially responsible for localization of hormone-producing cells and folliculo-stellate cells.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Distinctive localization of N‐ and E‐cadherins in rat anterior pituitary gland

et al. 2006

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“…5 and 6) correlated with the in vivo values found in our previous study (Figs. 9-13 in Noda et al, 2001). Statistical analyses showed a significant overall correlation between the rates in vivo and those in vitro (P Ͻ 0.05, r ϭ 0.67; Pearson's correlation coefficient test; Fig.…”

Section: Statistical Analysis Of Topographic Cell Affinitymentioning

confidence: 99%

“…However, when these features are identified by electron microscope, their interpretation is subjective according to the viewer. The interpretation of these data become standardized by observing a wide area of the gland by light microscopy after double-immunostaining the cells, and by statistical analysis (Noda et al, 2001).…”

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Rat anterior pituitary cells in vitro can partly reconstruct in vivo topographic affinities

et al. 2003

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Hormone-producing cells in the rat anterior pituitary gland are not randomly distributed; rather, there are specific topographic affinities among five cell types (Noda et al., Acta Histochem. Cytochem. 2001;34:313-319). In this study we reconstructed these affinities, at least partially, in primary monolayer culture. Pituitary cells collected from adult male rats were enzymatically dispersed and cultured for 72 hr at a density of 1 ϫ 10 5 cells/cm 2 . We double-immunostained cells using antibodies against hormones, and then used confocal laser microscopy to examine the ability of the cells to attach to each other. We also statistically analyzed the affinity of all combinations of the five types of hormone-producing cells. We observed clusters by electron microscopy to identify junctional complexes between the cells. Confocal laser microscopy indicated that the features and attachment patterns of hormoneproducing cells in vivo were similar to those in vitro. Statistical analyses revealed that the rates at which the five types of hormone-producing cells attached to growth hormone (GH)-, prolactin (PRL), and luteinizing hormone (LH)-producing cells were unequal, which suggests there are specific topographic affinities. The specific rates of adrenocorticotropic hormone (ACTH)-producing cell attachment to GH cells, LH to PRL cells, and PRL to LH cells were high, whereas that of PRL attachment to PRL cells was low. In addition, the rates correlated with the data from our previous in vivo study. Ultrastructural observations revealed few junctional complexes between hormone-producing cells. These results indicate that anterior pituitary hormone-producing cells can attach to specific types of cells by means of specific and/or nonspecific adhesion factors, and can reconstruct the topographic nature of the pituitary gland. Anat Rec Part A 272A: 548 -555, 2003.

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Cell Networks in Endocrine/Neuroendocrine Gland Function

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Tissier

et al. 2022

Comprehensive Physiology

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Reproduction, growth, stress and metabolism are determined by endocrine/neuroendocrine systems that regulate circulating hormone concentrations. All these systems generate rhythms and changes in hormone pulsatility observed in a variety of pathophysiological states. Thus, the output of endocrine/neuroendocrine systems must be regulated within a narrow window of effective hormone concentrations but must also maintain a capacity for plasticity to respond to changing physiological demands. Remarkably most endocrinologists still have a 'textbook' view of endocrine gland organization which has emanated from 20 th century histological studies on thin 2D tissue sections. However, 21 st century technological advances, including indepth 3D imaging of specific cell types have vastly changed our knowledge. We now know that various levels of multi-cellular organization can be found across different glands, that organizational motifs can vary between species and can be modified to enhance or decrease hormonal release. This review focuses on how the organization of cells regulates hormone output using three endocrine/neuroendocrine glands that present different levels of organization and complexity: the adrenal medulla, with a single neuroendocrine cell type; the anterior pituitary, with multiple intermingled cell types; and the pancreas with multiple intermingled cell types organized into distinct functional units. We give an overview of recent methodologies that allow the study of the different components within endocrine systems, and particularly their temporal and spatial relationships. We believe the emerging findings about network organization, and its impact on hormone secretion, are crucial to understanding how homeostatic regulation of endocrine axes is carried out within endocrine organs themselves.

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Topographic Affinities of Hormone-Producing Cells in the Rat Anterior Pituitary Gland.

Cited by 21 publications

References 17 publications

Distinctive localization of N‐ and E‐cadherins in rat anterior pituitary gland

Distinctive localization of N‐ and E‐cadherins in rat anterior pituitary gland

Rat anterior pituitary cells in vitro can partly reconstruct in vivo topographic affinities

Cell Networks in Endocrine/Neuroendocrine Gland Function

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