Topics on vitamin D in systemic lupus erythematosus: analysis of evidence and critical literature review

Abstract

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multiorgan inflammation, linked to the loss of immune tolerance to self-antigens and the production of a diversity of autoantibodies. The phenotype and progression of SLE have been linked to a combination of environmental, genetic, and hormonal factors. One such environmental factor is vitamin D, a vital hormone with well-established effects on mineral metabolism, skeletal health, and effects on cardiovascular system. The purpose of this article is to make the analysis of evidence and literature review of the pleomorphic effects of Vitamin D in SLE. The article is structured in topics of interest based in the authors' opinion and summarizes the evidence of studies and trials of vitamin D in SLE.

维生素d代谢通路单核苷酸多态性与系统性红斑狼疮的关联性研究进展

“…一些动物实验也证明适量维生素 D 可以起到降低狼疮鼠尿蛋 白含量、关节功能受损及减轻肾功能所受到的损害 [3] 。在遗 传层次研究中，罗雄燕、刘军麟等人对维生素 D 代谢通路基 因遗传多态性与 SLE 进行了进一步的研究 [4][5] ， 在国际文献中， Ozaki、Huang 等人也进行了相关性的研究 [6][7] 。论文针对维…”

Editorial: Cutting edge in systemic lupus erythematosus

“…Many patients are photosensitive and therefore have rigorous photoprotection strategies. Marinho et al [6] argue persuasively that vitamin D not only has a role in the pathobiology of SLE but also that vitamin D treatment is safe and may be effective in modulation of the immune response in active disease. Vitamin D may also influence cardiovascular risk in SLE.…”

Research Progress on the Relationship between Polymorphism and SLE of Vitamin D Metabolic Pathway Related Gene

“…Gao et al conducted a study on the relationship between vitamin D and SLE and found that 62.81% of the patients had vitamin D deficiency and 34.71% had severe vitamin D deficiency, indicating that vitamin D deficiency would significantly increase the incidence of SLE [2] . Some animal experiments have also shown that moderate vitamin D can reduce the lev-els of urine protein, impaired joint function and reduce the damage of renal function in lupus rats [3] . In the study of genetic level, Luo Xiongyan, Liu Junlin et al further studied the genetic polymorphism of vitamin D metabolic pathway genes and SLE [4][5] .…”