维生素D是维持机体正常生理活动的必需维生素。大量研究表明,维生素D作为脂溶性维生素,除钙磷代谢经典效应外,在机体的免疫调节、抗炎症反应、细胞增殖等方面的作用日受到研究者的关注。系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种是受环境、遗传等多种因素共同作用下导致多组织、多器官损害的特异性自身免疫性结缔组织病。在诸多因素中,维生素D代谢通路基因对于其发生发展起十分重要的调控作用。遗传多态性是个体差异和疾病发生发展的遗传基础,单核苷酸多态性是最常见的遗传变异。多篇文献表明,维生素D代谢通路基因单核苷酸多态性与SLE有相关联性。于是论文通过查阅相关文献,从基因层面出发,对维生素代谢通路基因单核苷酸多态性与SLE发生发展相关的研究进展进行归纳总结,为未来治疗提供新思路
从2019年12月至今,以中国武汉华南海鲜市场为中心在全国范围爆发了新型冠状病毒肺炎疫情,主要传播途径为呼吸道飞沫和接触传播,气溶胶和消化道等传播途径尚待明确,人群普遍易感。此次疫情其传播速度之快、范围之广,引起全国乃至全世界的广泛关注及重视。根据此次疫情发展的特点,论文对新型肺炎预防与控制进展进行综述。
二甲双胍是临床上治疗糖尿病的基础药物,常用于治疗2型糖尿病(Type 2 Diabetes Mellitus ,T2DM),其效果在T2DM的临床治疗中得到充分验证。但在使用二甲双胍药物治疗T2DM过程中仍有一定机率出现相关性乳酸酸中毒的情况,且病死率较高,那么使用二甲双胍药物治疗是否是糖尿病患者乳酸酸中毒的直接危险因素?论文针对二甲双胍的降糖机制、与乳酸酸中毒的相关研究进行梳理,以进一步探究二甲双胍与糖尿病患者乳酸酸中毒的关系,为二甲双胍药物在T2DM的临床治疗当中提供帮助与参考依据。
Human beings' exploration of life and health is advancing with the change of times. With the growth of age, human immunity is low and chronic diseases of organ system occur frequently, which have a serious impact on human health. Genes, environment and other random factors determine the outcome of longevity, while intestinal flora is considered to be the determinant of human health and longevity, mainly because it has a huge impact on human immunity, growth and development and other aspects. Research on the relationship between intestinal flora and longevity is of great scientific value, which is conducive to improving the health status of elderly people and increasing the overall life expectancy of human beings. The paper reviews the research progress of intestinal flora and longevity.
Vitamin D is a kind of fat soluble vitamin, which is essential for human body. In addition to the classical effect of regulating calcium and phosphorus metabolism, it can also participate in the cellular and humoral immune process by regulating the growth, differentiation and metabolism of immune cells. In recent years, a large number of studies have shown that vitamin D deficiency will increase the incidence of respiratory diseases. Respiratory diseases mainly include bronchial asthma, chronic obstructive pulmonary disease, tuberculosis, acute upper respiratory tract infection and pneumonia. Vitamin D metabolic pathway genes play a very important regulatory role in the process of transforming vitamin D into active vitamin D, mainly including cyp2r1, CYP27B1, cyp24a1, VDBP, VDR five genes. Genetic polymorphism of genes is the molecular basis of individual differences and disease development. This paper summarized the research on single nucleotide polymorphisms of vitamin D metabolic pathway gene and respiratory related diseases, and provided new ideas for future treatment.
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