Topically applied S-nitrosothiol-containing hydrogels as experimental and pharmacological nitric oxide donors in human skin

Abstract

Topical RSNOs produce a consistent, sustained and biologically effective release of NO on human skin in vivo, which offers advantages over currently available topical NO donors. Dermal nitrite concentration--the oxidation product of NO--is directly correlated with blood flow at low and moderate levels of blood flow. At high levels of blood flow, there is a reduction in dermal nitrite, which is presumed to be due to increased blood scavenging.

Modulated nitric oxide delivery in three-dimensional biomaterials for vascular functionality

“…The study suggested that F127 hydrogels might be used as the storage and controlled release material for S-nitrosothiols. A similar study was done by Seabra et al, [72] in which GSNO and SNAC were incorporated into Synperonic F-127 hydrogels [a triblock copolymer of poly(ethylene oxide) and poly(propylene oxide)]. When applied on human forearm skin, both GSNO-and SNAC-containing hydrogels increased blood flows over the 3 h study.…”

Nitric oxide-releasing polymeric nanoparticles againstTrypanosoma cruzi

“…The endogenous found molecule nitric oxide (NO) is not only a physiological mediator of important process such as the dilation of blood vessels [8,9], but also plays a key role in the immunological system against several pathogens [10][11][12]. Upon pathogen infection, activated macrophages and other immune cells inhibit pathogen replication by releasing several effector molecules, including NO [13].…”

Solid Films of Blended Poly(Vinyl Alcohol)/Poly(Vinyl Pyrrolidone) for Topical S-Nitrosoglutathione and Nitric Oxide Release

“…7 The incorporation of NO donors into non-toxic polymeric matrices may allow the use of solid materials or gels for topical transdermal applications or subcutaneous implants. 8,9 Several peptides and proteins containing the sulfhidryl (SH) moiety in cysteine (Cys) residues, like glutathione (GSH), which are found endogenously in the tissues and plasma of mammals, are believed to be involved in the metabolism of NO.…”