Topical Treatment of Dermatophytic Lesion on Mice (Mus musculus) Model

Sharma, B. K.; Kumar, Pramod; Joshi, S. C.

doi:10.1007/s12088-011-0109-2

Cited by 17 publications

(15 citation statements)

References 26 publications

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“…Apart from tannins, good antifungal activity is also shown by flavonoids. Bound flavonoids from roots of Lantana camara L. showed antifungal activity in studies on mice infected with Trichophyton mentagrophytes [ 287 ]. Complete recovery after application of the extract was observed after 16 days (drug reference after 12 days).…”

Section: Skin Diseasesmentioning

confidence: 99%

The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders

Działo

Mierziak

Korzun

et al. 2016

IJMS

537

327

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Phenolic compounds constitute a group of secondary metabolites which have important functions in plants. Besides the beneficial effects on the plant host, phenolic metabolites (polyphenols) exhibit a series of biological properties that influence the human in a health-promoting manner. Evidence suggests that people can benefit from plant phenolics obtained either by the diet or through skin application, because they can alleviate symptoms and inhibit the development of various skin disorders. Due to their natural origin and low toxicity, phenolic compounds are a promising tool in eliminating the causes and effects of skin aging, skin diseases, and skin damage, including wounds and burns. Polyphenols also act protectively and help prevent or attenuate the progression of certain skin disorders, both embarrassing minor problems (e.g., wrinkles, acne) or serious, potentially life-threatening diseases such as cancer. This paper reviews the latest reports on the potential therapy of skin disorders through treatment with phenolic compounds, considering mostly a single specific compound or a combination of compounds in a plant extract.

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Section: Skin Diseasesmentioning

confidence: 99%

The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders

Działo

Mierziak

Korzun

et al. 2016

IJMS

537

327

View full text Add to dashboard Cite

show abstract

“…13 14 Terbinafine has also been used systemically in the treatment of dermatophytosis in dogs and cats, 15 16 as well as in the treatment of canine Malassezia dermatitis. [17][18][19] In addition, topical terbinafine has been used successfully to treat dermatophytosis in mice, 20 and in a guinea pig model. 21 Of note, Sagit and others, 22 report no toxicity to the middle ear of rats when terbinafine was applied intratympanically.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a single‐administration ototopical treatment for canine otitis externa: a randomised trial

Blake

Keil

Kwochka

et al. 2017

Veterinary Record Open

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ObjectiveTo evaluate the efficacy and safety of a new, single-administration Otic Solution containing florfenicol, terbinafine and mometasone furoate for the treatment of canine otitis externa (OE).DesignThe clinical efficacy and safety study was a multicentre, controlled, masked and randomised field study conducted over 30 days. Two hundred and twenty-one (221) client-owned dogs of varying breeds with diagnosed bacterial and/or fungal OE were enrolled.ProcedureDogs were randomised to either Otic Solution or control groups. Evaluations were conducted over a minimum period of 30 days with a primary effectiveness endpoint based on the improvement in a clinical severity score at the final visit (day 30). Safety analyses were based on clinical and laboratory parameters and the occurrence of adverse events.ResultsThe Otic Solution group demonstrated a significantly higher treatment success rate compared with that observed for the control group (72.5 per cent v 11.1 per cent, P value=0.0001) for cases of OE caused by Staphylococcus pseudintermedius and Malassezia pachydermatis. No significant safety findings were reported.Conclusions/clinical relevanceThis new ototopical formulation provides safe and effective treatment of canine OE and is an important alternative antimicrobial for this indication. The single-administration dosage regimen eliminates opportunities for client dosage administration errors and medication stockpiling.

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“…The research findings on experimentally induced dermatophytic lesion in mice reported by Sharma et al .,[ 7 ] indicate that T. Procumbens plant extract is an excellent topical antifungal agent for the cure of dermatophytosis. This plant also known to have antibacterial properties.…”

Section: Introductionmentioning

confidence: 99%

Identification of bacterial endophytes associated with traditional medicinal plant Tridax procumbens Linn.

Preveena¹,

Bhore²

2013

Ancient Sci Life

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Background:In traditional medicine, Tridax procumbens Linn. is used in the treatment of injuries and wounds. The bacterial endophytes (BEs) of medicinal plants could produce medicinally important metabolites found in their hosts; and hence, the involvement of BEs in conferring wound healing properties to T. Procumbens cannot be ruled out. But, we do not know which types of BEs are associated with T. Procumbens.Objective:The objective of this study was to investigate the fast growing and cultivable BEs associated with T. procumbens.Materials and Methods:Leaves and stems of healthy T. Procumbens plants were collected and cultivable BEs were isolated from surface-sterilized leaf and stem tissue samples using Luria-Bertani (LB) agar (medium) at standard conditions. A polymerase chain reaction was employed to amplify 16S rRNA coding gene fragments from the isolates. Cultivable endophytic bacterial isolates (EBIs) were identified using 16S rRNA gene nucleotide sequence similarity based method of bacterial identification.Results:Altogether, 50 culturable EBIs were isolated. 16S rRNA gene nucleotide sequences analysis using the Basic Local Alignment Search Tool (BLAST) revealed identities of the EBIs. Analysis reveals that cultivable Bacillus spp., Cronobacter sakazakii, Enterobacter spp., Lysinibacillus sphaericus, Pantoea spp., Pseudomonas spp. and Terribacillus saccharophilus are associated with T. Procumbens.Conclusion:Based on the results, we conclude that 24 different types of culturable BEs are associated with traditionally used medicinal plant, T. Procumbens, and require further study.

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Topical Treatment of Dermatophytic Lesion on Mice (Mus musculus) Model

Cited by 17 publications

References 26 publications

The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders

The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders

Evaluation of a single‐administration ototopical treatment for canine otitis externa: a randomised trial

Identification of bacterial endophytes associated with traditional medicinal plant Tridax procumbens Linn.

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