Topical timolol for postacne erythema

Afra, T. P.; T, Muhammed Razmi; De, Dipankar

doi:10.1016/j.jaad.2020.04.144

Cited by 8 publications

(9 citation statements)

References 3 publications

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“…; however, at 16 weeks, the erythema recurred 20 . In a case study looking at post‐acne erythema and hyperpigmentation, both showed improvement with topical timolol on subjective dermoscopic evaluation following 3 months of timolol therapy 21 …”

Section: Indicationsmentioning

confidence: 99%

Topical timolol in dermatology: infantile haemangiomas and beyond

Alzaid

Al-Naseem

Al‐Niaimi

et al. 2022

Clin Experimental Derm

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Timolol, a nonselective b-adrenergic receptor blocker, is well-tolerated and is becoming increasingly popular in dermatology, especially in the management of infantile haemangioma (IH). Its effects are mainly due to vasoconstriction, inhibition of angiogenesis and keratinocyte migration promotion for re-epithelialization and wound healing. We review the evidence behind the use of timolol in several dermatological conditions including IH, pyogenic granulomas, Kaposi sarcoma, chronic wound healing, postsurgical wounds, acne vulgaris, rosacea, eczema and red scrotum syndrome.

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Section: Indicationsmentioning

confidence: 99%

Topical timolol in dermatology: infantile haemangiomas and beyond

Alzaid

Al-Naseem

Al‐Niaimi

et al. 2022

Clin Experimental Derm

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“…To date, various treatment approaches including topical therapy, chemical peels, and energy‐based devices have been used in treatment of PAE 5–28 . Selection of treatment strategy depends on the presence of other accompanied skin lesions such as acne scars, active acne lesions or PIH, availability of devices, patient's skin type, patient's preferences regarding cost of treatment and recovery time 5–28 . Nowadays, lasers gain wide spectrum of popularity in the dermatology and cosmetic field due to rapid response and desirable outcome.…”

Section: Discussionmentioning

confidence: 99%

“…Post‐acne erythema (PAE) usually develops in subjects with lighter skin phototypes after improvement of active acne lesions. PAE is defined as erythematous macule (secondary to release of inflammatory cytokines such as interleukin (IL)‐6 and tumor necrosis factor (TNF)‐α that remains after resolution of inflammatory acne lesions 5–28 . Dilatation of microcapillaries in papillary dermis secondary to healing process and intracapillary aggregations of erythrocytes have essential roles in development of PAE.…”

Section: Introductionmentioning

confidence: 99%

Treatment protocols and efficacy of light and laser treatments in post‐acne erythema

Amiri

Khalili

Mohammadi

et al. 2022

J of Cosmetic Dermatology

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“…In addition to previously reviewed dermatoses in 2017 and 2018 [ 49 , 50 ], our systematic review included recent studies about the role of beta-blockers in different dermatological diseases. Topical timolol resulted in favorable outcomes in post acne erythema and scars [ 23 , 28 , 29 ]. It resulted in decreased acne severity, less erythema, and pigmentation.…”

Section: Discussionmentioning

confidence: 99%

“…Currently reviewed dermatoses: Post-acne erythema Topical beta-blockers A study by Afra T.P. et al [28] demonstrated the therapeutic effect of topical timolol maleate 0.5% ophthalmic solution in a case of remarkable post-inflammatory erythema and atrophic scars. They observed a significant improvement in post-inflammatory erythema; only shallow rolling scars were left with no pigmentation.…”

Section: Rosacea and Acnementioning

confidence: 99%

The Role of Systemic and Topical Beta-Blockers in Dermatology: A Systematic Review

Alhazmi

Basendwh

Aman

et al. 2022

Dermatol Ther (Heidelb)

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Introduction: Beta-blockers are proven to be safe and cost-effective agents in treating multiple dermatological conditions, which is why they are considered as an interesting and good alternative therapeutic agent by dermatologists. To our knowledge, there has been no comprehensive systematic review to date summarizing the role of both systemic and topical betablockers in dermatology. Methods: In this systematic review, we aim to review recent and relevant published literature in order to provide a comprehensive evidencebased summary to inform dermatologists. Results: An electronic-based literature search was carried out during October-December 2021 in the databases PubMed (MEDLINE), SCOPUS (EMBASE), and Cochrane Library. Furthermore, bibliographic sources were also reviewed for the selected articles. We followed The Preferred Reporting Items for Systematic Reviews and Meta-analyses 2020 (PRISMA) guidelines. We reviewed published literature about the role of beta-blockers in dermatology for the time period (January 2016 to December 2021). Conclusions: A total of 126 publications were retrieved from different databases, of which 59 studies were finally included in our review after excluding non-eligible literature in accordance with our inclusion and exclusion criteria. The included articles consisted of meta-analyses, systematic reviews, clinical trials, retrospective and prospective cohort studies, case-control studies, case series, and case reports. In general, data in reviewed literature showed that both systemic and topical beta-blockers were reliable and safe therapeutic options in treating different dermatoses. Their effect has been studied as a mono-therapy, also as an adjuvant therapy combined with other current disease-specific therapeutic modalities such as lasers, radiation, chemotherapy, corticosteroids, or other betablockers options. Local and systemic adverse effects were mainly minor and non-significant.

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Topical timolol for postacne erythema

Cited by 8 publications

References 3 publications

Topical timolol in dermatology: infantile haemangiomas and beyond

Topical timolol in dermatology: infantile haemangiomas and beyond

Treatment protocols and efficacy of light and laser treatments in post‐acne erythema

The Role of Systemic and Topical Beta-Blockers in Dermatology: A Systematic Review

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