Topical tenoxicam from pharyngeal pack reduces postoperative sore throat

Elhakim, M.; Siam, Ahmed Ezzat; Rashed, I El; Hamdy, M. H.

doi:10.1034/j.1399-6576.2000.440612.x

Cited by 27 publications

(23 citation statements)

References 10 publications

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“…It may also be associated with edema, congestion, and pain. 19,20 Reduction of this inflammation by ketamine gargling may be the reason for decrease in the incidence and severity of POST in our study.…”

Section: Resultsmentioning

confidence: 83%

Gargling With Ketamine Attenuates Post - Operative Sore Throat

Tejashwini¹,

Jagadish²

2014

jemds

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Section: Resultsmentioning

confidence: 83%

Gargling With Ketamine Attenuates Post - Operative Sore Throat

Tejashwini¹,

Jagadish²

2014

jemds

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“…7,8 Tindakan farmakologi yang dapat dilakukan adalah memberikan inhalasi beklometason, steroid topikal, kumur-kumur dengan azulen sulfonat atau non-steroid anti-inflammatory drug (NSAID) seperti aspirin dan benzidamin hidroklorida, dan kumur-kumur menggunakan jenis antagonis reseptor N-methyl D-aspartate (NMDA) seperti ketamin. [9][10][11][12][13] Beberapa penelitian menyimpulkan bahwa pemberian antagonis reseptor NMDA selain berperanan sebagai antinosisepsi juga dapat bersifat sebagai antiinflamasi. Reseptor NMDA tidak hanya terdapat di susunan saraf pusat tetapi juga di saraf tepi.…”

Section: Pendahuluanunclassified

“…18 Penggunaan propofol dengan dosis induksi dapat memengaruhi stabilitas hemodinamik (tekanan darah), sedangkan pada penggunaan ketamin yang mempunyai efek analgetik dapat menimbulkan respons kardiovaskular, seperti peningkatan denyut jantung, tekanan darah, serta cardiac output sehingga tekanan darah dapat tetap stabil. 12 Pada penelitian ini tidak terdapat perubahan hemodinamik (tekanan darah) pada kelompok ketamin dan NaCl. Penurunan tekanan darah dan tekanan balon ETT memberikan pengaruh pada kejadian POST.…”

Section: -19unclassified

Ketamin Kumur Efektif untuk Mengurangi Sore Throat Pascaintubasi

Satriyanto¹,

Husaeni²,

Wargahadibrata³

2014

jap

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AbstrakTindakan intubasi merupakan salah satu penyebab trauma mukosa jalan napas tersering yang mengakibatkan nyeri tenggorok pascaintubasi atau post operative sore throat (POST), telah dilaporkan insidensi ini sekitar 6-50% setelah tindakan anestesi umum endotrakeal. Salah satu cara pencegahan POST adalah dengan menggunakan ketamin kumur sebelum induksi, karena ketamin mempunyai kemampuan sebagai antinosisepsi dan antiinflamasi. Limapuluh pasien dengan ASA I-II, yang telah dilakukan tindakan operasi elektif kasus ginekologi dengan anestesi umum endotrakeal, yang dilakukan penelitian secara prospektif dengan melakukan uji klinis rancangan acak lengkap terkontrol buta ganda (double blind randomized controlled trial) di Central Operating Theatre (COT) Rumah Sakit Dr. Hasan Sadikin Bandung pada April-Juli 2009. Pasien secara ancak dibagi menjadi dua kelompok dengan 25 subjek tiap kelompok, kelompok I, diberikan ketamin 0,5 mg/kgBB dalam NaCl 0,9% 30 mL; kelompok II, NaCl 0,9% sebanyak 30 mL. Pasien diminta untuk berkumur dengan cairan ini selama 30 detik, 5 menit sebelum induksi. POST dinilai pada jam T0, T2, T4, dan T24 setelah operasi dengan 4 skala (0-3). Kejadian POST lebih sering terjadi pada kelompok II dibandingkan dengan kelompok I pada T0, T2 dan T4 dan kelompok II secara signifikan lebih berat menderita POST dibandingkan dengan kelompok I (p<0,05). Simpulan penelitian ini adalah ketamin kumur mengurangi kejadian dan derajat POST. Kata kunci: Intubasi, ketamin kumur, post operative sore throat (POST) Ketamine Gargle to Reducing Post Operative Sore Throat (POST) Following Intubation AbstractTracheal intubation is a foremost cause of trauma to the airway mucosa, resulting in post operative sore throat (POST) with reported incidences of 6-50%. We compared the effectiveness of ketamine gargles compared to placebo in preventing POST after endotracheal general anesthesia. One of the POST preventions by using ketamine gargle before induction, because ketamine has anti-nociceptive and anti-inflamatory properties Fifty, ASA I-II, patients undergoing elective surgery for gynecologic under general anaesthesia endotracheal were enrolled in a double blind randomized controlled trial study at Central Operating Theatre (COT) Dr. Hasan Sadikin Hospital Bandung during April-June 2009. Patients were randomly allocated into two groups of 25 subjects each: Group I, receiving ketamine 0.5 mg/kgBW in saline 30 mL; Group II, receiving saline 30 mL. Patients were asked to gargle this mixture for 30 seconds, 5 minutes before induction of anaesthesia.POST was graded at 0, 2, 4, and 24 h after operation on a four-point scale (0-3). POST occurred more frequently in Group II, when compared with Group I, at 0, 2, and 4 h and significantly more patients suffered POST in Group II compared with Group I (p<0.05). The conclusions of this study revealed that ketamine gargles reduces the incidence and degree of POST.

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“…It had been rated by patients as the eighth most adverse effect in the post-operative period. [5891011] Despite attempts to reduce its incidence and severity,[12131415] there are currently no effective therapies for the prevention of POST and hoarseness in patients. Various trials have been used for reducing POST with variable success.…”

Section: Introductionmentioning

confidence: 99%

Intravenous dexamethasone versus ketamine gargle versus intravenous dexamethasone combined with ketamine gargle for evaluation of post-operative sore throat and hoarseness: A randomized, placebo-controlled, double blind clinical trial

et al. 2014

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Background:Sore throat and hoarseness are the most frequent subjective complaints after tracheal intubation for general anesthesia. We conducted a prospective, randomized, double-blind, placebo controlled study to evaluate the efficacy of intravenous (IV) dexamethasone plus ketamine gargle for reducing the incidence and severity of post-operative sore throat (POST) and hoarseness.Materials and Methods:140 patients (aged 16-65 year) scheduled for elective surgery were enrolled. Patients were randomly allocated into four groups of 35 subjects each: Group K, gargled 40 mg ketamine in 30 ml saline; Group D, were infused 0.2 mg/kg IV dexamethasone; Group KD, gargled 40 mg ketamine in 30 ml saline plus 0.2 mg/kg IV dexamethasone; Group P (placebo) that received saline (gargle and IV). POST was graded at 0, 2, 4, 8, 16 and 24 h after operation on a four-point scale (0-3).Results:The incidence and severity of POST were significantly lower in Group KD, compared with the other groups at all times after tracheal extubation for up to 24 h (P < 0.05). Also the incidence and severity of hoarseness were significantly lower in each Groups of KD and K and D compared with group placebo (P < 0.05).Conclusion:The prophylactic use of 0.2 mg/kg of IV dexamethasone plus ketamine gargle significantly reduced the incidence and severity of POST compared with using each of these drugs alone or using placebo.

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Topical tenoxicam from pharyngeal pack reduces postoperative sore throat

Abstract: The intraoperative use of a tenoxicam-impregnated gauze pack is effective in reducing moderate or severe postoperative sore throat following the use of throat pack.

Cited by 27 publications

References 10 publications

Gargling With Ketamine Attenuates Post - Operative Sore Throat

Gargling With Ketamine Attenuates Post - Operative Sore Throat

Ketamin Kumur Efektif untuk Mengurangi Sore Throat Pascaintubasi

Intravenous dexamethasone versus ketamine gargle versus intravenous dexamethasone combined with ketamine gargle for evaluation of post-operative sore throat and hoarseness: A randomized, placebo-controlled, double blind clinical trial

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