Topical tacrolimus in the treatment of inverse psoriasis in children

Steele, Jennifer A.; Choi, Christine; Kwong, Pearl

doi:10.1016/j.jaad.2005.05.036

Cited by 70 publications

(58 citation statements)

References 17 publications

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“…These agents include tacrolimus and pimcrolimus used in the treatment of atopic dermatitis with no license to treat psoriasis disease. There are several studies regarding the successful treatment by topical Calcineurin inhibitors for psoriasis in adults (23)(24)(25). Calcineurin inhibitors can be used safely in inverse psoriasis, especially in children due to no steria and no atrophic adverse effects (25).…”

Section: Calcineurin Inhibitorsmentioning

confidence: 99%

“…There are several studies regarding the successful treatment by topical Calcineurin inhibitors for psoriasis in adults (23)(24)(25). Calcineurin inhibitors can be used safely in inverse psoriasis, especially in children due to no steria and no atrophic adverse effects (25). In a study, topical tacrolimus 0.1% twice daily for four weeks was effective in the treatment of psoriasis (26).…”

Section: Calcineurin Inhibitorsmentioning

confidence: 99%

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Management of Psoriasis in Children: a Narrative Review

Hajheydari¹,

Sarparast²,

Shahmohammadi³

2015

J Pediatr Rev

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Psoriasis is an inherited chronic inflammatory papulosquamous disorder with a variable clinical spectrum affecting about 0.5% to 2% of children and adolescence. In spite of all performed researches around the world for seeking better treatments with fewer adverse effects to control the disease, there is still no cure for psoriasis. Treatment of psoriasis in children is very conservative and many therapies used for adults may not be appropriate for children due to possible long-term or delayed adverse effects. A wide range of therapeutic options are existed including; topical therapy, phototherapy, chemotherapy, systemic therapies and biologic therapies. Here in, because of the lack of data in this specific field of dermatology, we decided to review the current therapies of childhood psoriasis.

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Section: Calcineurin Inhibitorsmentioning

confidence: 99%

Section: Calcineurin Inhibitorsmentioning

confidence: 99%

Management of Psoriasis in Children: a Narrative Review

Hajheydari¹,

Sarparast²,

Shahmohammadi³

2015

J Pediatr Rev

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“…Tacrolimus was significantly more effective for facial and genitofemoral areas of psoriasis, compared with calcitriol ointment [37]. Taken together, topical tacrolimus is successfully used for facial and intertriginous psoriasis [38], even in pediatric patients [39,40]. Facial psoriasis lesions are usually not covered by thick scales, and thus the penetration is not blocked, which may in part explain the efficacy of topical tacrolimus.…”

Section: Topical Tacrolimus Therapy For Psoriasismentioning

confidence: 99%

Topical Tacrolimus for Psoriasis

Yamamoto¹

2009

TOALLJ

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Tacrolimus ointment is an agent approved for the treatment of atopic dermatitis; however, tacrolimus has been expected also as one of the promising therapeutic strategies for other T-cell mediated inflammatory skin disorders. Recent progress have demonstrated that topical tacrolimus shows beneficial effects for psoriasis depending on sites. In particular, facial, intertriginous, and genital psoriasis respond to topical tacrolimus dramatically in a short period. Further, topical tacrolimus is tolerable also for child psoriasis. Because topical tacrolimus does not induce either skin atrophy or telangiectasia different from corticosteroids, it is recommended to be a first choice. The most proper way of topical tacrolimus therapy at present is to use this ointment intermittently after the remission was once obtained, paying attention to its adverse effects.

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“…der Psoriasis aber nicht zugelassen. Ihre Wirksamkeit konnte jedoch auch bei der kindlichen Psoriasis verschiedentlich dokumentiert werden [4,32]. Aufgrund des fehlenden atrophogenen Potenzials eignen sich Calcineurininhibitoren insbesondere zur Therapie der Körperfalten und des Gesichts, ggf.…”

Section: Introductionunclassified

“…Aufgrund des fehlenden atrophogenen Potenzials eignen sich Calcineurininhibitoren insbesondere zur Therapie der Körperfalten und des Gesichts, ggf. nach kurzer Anbehandlung mit einem topischen Glukokortikoid [4,32].…”

Section: Introductionunclassified

Psoriasis im Kindes- und Jugendalter

Benoit

Hamm

2009

Hautarzt

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Psoriasis starts in the first two decades of life in about one-third of patients. Initially the diagnosis may be difficult because of atypical or mild involvement. Plaque psoriasis is the most frequent type in children, just as in adults. However, lesions are often smaller, thinner and less scaly. Treatment of childhood psoriasis represents a special challenge to dermatologists since many therapeutic agents are not approved and guidelines are generally lacking for this age group. Apart from clinical type, severity of the disease and patient's age, the choice of treatment must be based on safety concerns and accessibility of treatment. We herein focus on the peculiarities of clinical presentations and on the management of psoriasis in children and adolescents.

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Topical tacrolimus in the treatment of inverse psoriasis in children

Cited by 70 publications

References 17 publications

Management of Psoriasis in Children: a Narrative Review

Management of Psoriasis in Children: a Narrative Review

Topical Tacrolimus for Psoriasis

Psoriasis im Kindes- und Jugendalter

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