Topical Scar Treatment Products for Wounds: A Systematic Review

Tran, Benjamin; Wu, Jashin J.; Ratner, Désirée; Han, George

doi:10.1097/dss.0000000000002712

Cited by 15 publications

(13 citation statements)

References 34 publications

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“…There are numerous more or less invasive treatments aimed at improving residual aesthetic stigmatizations and facial dysfunctions ( Table 1 , [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ]), but an optimal treatment has not yet been identified [ 44 , 45 ]. In fact, although many interventions appear promising, sometimes the results reported in the literature are conflicting [ 32 , 33 , 34 , 35 ], or interventions suitable for some types of scars are not effective for others [ 29 , 43 , 44 , 45 ].…”

Section: Introductionmentioning

confidence: 99%

Vacuum and Electromagnetic Fields Treatment to Regenerate a Diffuse Mature Facial Scar Caused by Sulfuric Acid Assault

Veronese

Brunetti²,

Minichino³

et al. 2022

Bioengineering

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Acid attacks are on the rise, and they cause extensive and deep burns, especially on the face. The treatments used to improve the aesthetic, functional and social impact of non-acid scars do not always prove useful for acid scars. This article reports the case of a woman with an extended, mature, acid facial scar, caused by sulfuric acid assault, treated with a recent new procedure that combines the application of vacuum and electromagnetic fields. Before and after the treatment, the aesthetic appearance, and motor function of the face and neck were evaluated, as well as the level of hydration, the amount of sebum, the elasticity, and the pH of the skin. The improvements highlighted after the treatment of the aesthetic and functional characteristics of the face and neck, and of the physical parameters of the skin seemed to indicate that this particular treatment induces tissue regeneration, even in the nerve component. However, it is evident that the rehabilitation pathways of facial wounds and scars must be personalized, and must include continuous psychological support for the patient.

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Section: Introductionmentioning

confidence: 99%

Vacuum and Electromagnetic Fields Treatment to Regenerate a Diffuse Mature Facial Scar Caused by Sulfuric Acid Assault

Veronese

Brunetti²,

Minichino³

et al. 2022

Bioengineering

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“…Ultimately, the once functional tissue is transformed into a scar composed mainly of fibroblasts and a collagenous extracellular matrix. A fully healed scar will never be as strong as the original tissue, but can recover up to 80% of the tensile strength of the original (11,15). Remodeling will continue after this scar has formed, organizing and degrading excess collagen in an attempt to return to its original unwounded state (11,15).…”

Section: Normal Wound Healingmentioning

confidence: 99%

“…The collagen that was laid down by fibroblasts is re-organized to better strengthen the healing tissue. Myofibroblasts, or contractile fibroblasts, contract the periphery of the wounded area to reduce the size of the wound ( 1 , 12 , 15 ). Ultimately, the once functional tissue is transformed into a scar composed mainly of fibroblasts and a collagenous extracellular matrix.…”

Section: Introductionmentioning

confidence: 99%

The effects of mechanical force on fibroblast behavior in cutaneous injury

et al. 2023

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Wound healing results in the formation of scar tissue which can be associated with functional impairment, psychological stress, and significant socioeconomic cost which exceeds 20 billion dollars annually in the United States alone. Pathologic scarring is often associated with exaggerated action of fibroblasts and subsequent excessive accumulation of extracellular matrix proteins which results in fibrotic thickening of the dermis. In skin wounds, fibroblasts transition to myofibroblasts which contract the wound and contribute to remodeling of the extracellular matrix. Mechanical stress on wounds has long been clinically observed to result in increased pathologic scar formation, and studies over the past decade have begun to uncover the cellular mechanisms that underly this phenomenon. In this article, we will review the investigations which have identified proteins involved in mechano-sensing, such as focal adhesion kinase, as well as other important pathway components that relay the transcriptional effects of mechanical forces, such as RhoA/ROCK, the hippo pathway, YAP/TAZ, and Piezo1. Additionally, we will discuss findings in animal models which show the inhibition of these pathways to promote wound healing, reduce contracture, mitigate scar formation, and restore normal extracellular matrix architecture. Recent advances in single cell RNA sequencing and spatial transcriptomics and the resulting ability to further characterize mechanoresponsive fibroblast subpopulations and the genes that define them will be summarized. Given the importance of mechanical signaling in scar formation, several clinical treatments focused on reducing tension on the wound have been developed and are described here. Finally, we will look toward future research which may reveal novel cellular pathways and deepen our understanding of the pathogenesis of pathologic scarring. The past decade of scientific inquiry has drawn many lines connecting these cellular mechanisms that may lead to a map for the development of transitional treatments for patients on the path to scarless healing.

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“…Conservative treatment procedures such as scar massage and compression therapy using compression dressings or scar plasters containing silicone are gold standard therapies to obtain flat, soft, and aesthetically acceptable scars [8]. Furthermore, for functional rehabilitation, physiotherapy and occupational therapy remain integral treatment pillars [4].…”

Section: Conservative Treatment Optionsmentioning

confidence: 99%

Non-Invasive and Surgical Modalities for Scar Management: A Clinical Algorithm

Dastagir

Obed

Bucher

et al. 2021

JPM

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Scars can lead to aesthetic and functional impairments. The treatment of scars requires meticulous planning and an individually adapted therapeutic strategy. A conceptual algorithm for scar treatment makes everyday clinical work easier for the practitioner and offers more safety for the patient. Based on a retrospective analysis of 1427 patients who presented for treatment of a variety of scars, we developed an algorithm for scar management and treatment. The treatments are presented using case descriptions. Additionally, an electronic search of MEDLINE, EMBASE, and ClinicalTrials.gov databases was performed utilizing combinations of relevant medical subject headings for “scar treatment”, “hypertrophic scar treatment” and “keloid treatment”. Reference lists of relevant articles and reviews were hand-searched for additional reports. Observed outcomes included: conservative scar therapy, minimally invasive scar therapy, and surgical scar therapy using local, regional and free flaps. With this work, we provide an algorithm for safe scar treatment. For better understanding, we have described a clinical case for each algorithm modality.

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Topical Scar Treatment Products for Wounds: A Systematic Review

Cited by 15 publications

References 34 publications

Vacuum and Electromagnetic Fields Treatment to Regenerate a Diffuse Mature Facial Scar Caused by Sulfuric Acid Assault

Vacuum and Electromagnetic Fields Treatment to Regenerate a Diffuse Mature Facial Scar Caused by Sulfuric Acid Assault

The effects of mechanical force on fibroblast behavior in cutaneous injury

Non-Invasive and Surgical Modalities for Scar Management: A Clinical Algorithm

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