Topical Oxygen Emulsion

Davis, Stephen C.; Cazzaniga, Alejandro L.; Ricotti, Carlos; Zalesky, Paul; Hsu, Li Chien; Creech, Jeffrey; Eaglstein, William H.; Mertz, Patricia M.

doi:10.1001/archderm.143.10.1252

Cited by 59 publications

(19 citation statements)

References 103 publications

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“…The data are consistent with our previous report of porcine in vivo study with salt-split technique (9). The stimulatory effects could be the direct effect of TOE and its subsequently generated reactive oxygen species (ROS) on keratinocyte migration and proliferation (2,(23)(24)(25)(26).…”

Section: Discussionsupporting

confidence: 91%

“…However, its ability to penetrate the skin is limited (9,10). Recently developed topical aqueous oxygen emulsions (TOE) can overcome these limitations (9)(10)(11). TOE contains supersaturated oxygen which can be delivered topically.…”

Section: Introductionmentioning

confidence: 99%

“…The formulation is based on perfluorocarbon droplets being encapsulated within an aqueous continuous phase allowing slow release of oxygen over time. The oxygen solubility of the perfluorocarbon is relatively high, approximately twenty times greater than water; therefore, it has a high oxygen-carrying capacity (9,11). We have previously reported that TOE increased the healing rate in partial-thickness wounds in a porcine study in vivo (9).…”

Section: Introductionmentioning

confidence: 99%

“…The oxygen solubility of the perfluorocarbon is relatively high, approximately twenty times greater than water; therefore, it has a high oxygen-carrying capacity (9,11). We have previously reported that TOE increased the healing rate in partial-thickness wounds in a porcine study in vivo (9). However, the mechanisms involved and molecular effects of the TOE on wound healing are still unknown.…”

Section: Introductionmentioning

confidence: 99%

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Effects of a topical aqueous oxygen emulsion on collagen deposition and angiogenesis in a porcine deep partial‐thickness wound model

Ollague

Zhu

et al. 2013

Experimental Dermatology

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Additional Supporting Information may be found in the online version of this article: Figure S1. Inhibition of E6 and E7 expressions by inducible shRNA technique alters p53 and pRb protein levels. Figure S2. Characterization of the effects of viral E6 and E7 gene inhibition on cell proliferation.Data S1. Materials and methods. Abstract: A porcine deep partial-thickness wound model was used to evaluate the effects of a newly developed topical aqueous oxygen emulsion (TOE) on wound repair. The wounds were treated with TOE, which contains super-saturated oxygen or vehicle control. Semiquantitative immunofluorescent staining was performed to examine protein production for type I and type III collagen and vascular endothelial growth factor (VEGF). Immunofluorescent staining revealed higher protein levels of type I and type III collagen and VEGF in the TOE treatment group. Histological analysis also revealed improved angiogenesis and granulation tissue formation with topical TOE treatment and was consistent with the protein expression. In addition, the histology examination demonstrated faster epithelialization in wounds treated with TOE. The study suggests that sustained high levels of oxygen released by TOE may promote the process of wound repair through increasing collagen deposition and angiogenesis as well as stimulating epithelialization.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of a topical aqueous oxygen emulsion on collagen deposition and angiogenesis in a porcine deep partial‐thickness wound model

Ollague

Zhu

et al. 2013

Experimental Dermatology

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“…In 2007, the use of etanercept has been reported as second TNF-α blocker with efficacy in a single case of PRP [31]. Since then, 6 additional patients have been published which responded well to etanercept that has been given up to 12 months.…”

Section: Discussionmentioning

confidence: 99%

Pityriasis Rubra Pilaris: Treatment with Biologics – A New Promising Therapy?

2012

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Pityriasis rubra pilaris (PRP) includes a spectrum of rare chronic inflammatory disorders with papulosquamous eruptions of unknown cause. Different etiologies have been proposed such as vitamin A metabolism dysfunction, association with autoimmune disorders, infection or malignancies. However, PRP seems to be a polygenic skin disorder. Classical systemic treatment is empirical and includes retinoids and methotrexate; however, only few series on treatments exist. Recently there has been an increasing number of reports documenting that new biologicals and in particular TNF-α blockers are safe and effective.

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Calcium Peroxide‐Based Hydrogel Patch with Sustainable Oxygenation for Diabetic Wound Healing

Li,

Lu,

Yang

et al. 2024

Adv Healthcare Materials

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Nonhealing diabetic wounds are predominantly attributed to the inhibition of angiogenesis, re‐epithelialization, and extracellular matrix synthesis caused by hypoxia. Although oxygen therapy has demonstrated efficacy in promoting healing, its therapeutic impact remains suboptimal due to unsustainable oxygenation. Here we propose an oxygen‐releasing hydrogel patch embedded with polyethylene glycol‐modified calcium peroxide microparticles, which sustainably releases oxygen for 7 days without requiring any supplementary conditions. The released oxygen effectively promotes cell migration and angiogenesis under hypoxic conditions as validated in vitro. The in vivo tests in diabetic mice models show that the sustainably released oxygen significantly facilitates the synthesis of extracellular matrix, induces angiogenesis, and decreases the expression of inflammatory cytokines, achieving a diabetic wound healing rate of 84.2% on day 7, outperforming the existing oxygen‐releasing approaches. Moreover, the proposed hydrogel patch is designed with porous, soft, antibacterial, biodegradable, and storage stability for 15 days. The proposed hydrogel patch is expected to be promising in clinics treating diabetic wounds.This article is protected by copyright. All rights reserved

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Topical Oxygen Emulsion

Cited by 59 publications

References 103 publications

Effects of a topical aqueous oxygen emulsion on collagen deposition and angiogenesis in a porcine deep partial‐thickness wound model

Effects of a topical aqueous oxygen emulsion on collagen deposition and angiogenesis in a porcine deep partial‐thickness wound model

Pityriasis Rubra Pilaris: Treatment with Biologics – A New Promising Therapy?

Calcium Peroxide‐Based Hydrogel Patch with Sustainable Oxygenation for Diabetic Wound Healing

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