Hypothyroidism mainly affects adults. The improper functioning of the thyroid gland results in hormone deficiency, and the slowdown of the metabolism of the whole body and skin changes. The study aimed to present, based on a literature review, skin symptoms occurring in hypothyroidism and substances that can reduce the adverse effects of thyroid hormone deficiency, and support skin care. The cosmetics rich in moisturizing ingredients, antioxidants, keratolytic, and immunomodulating substances are recommended to strengthen the skin barrier.