Topical nanodelivery system of lutein for the prevention of selenite-induced cataract

Bodoki, Ede; Voștinaru, Oliviu; Samoilă, O; Dinte, Elena; Bodoki, Andreea; Swetledge, Sean; Astete, Carlos E.; Sabliov, Cristina M.

doi:10.1016/j.nano.2018.09.016

Cited by 28 publications

(32 citation statements)

References 53 publications

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“…In the high fat diet Wistar rats, the association of lutein loaded PLGA-NPs to Prednison, decreased the increased values for glycaemia, triglyceridemia and improved the systemic antioxidant defence of the body. Bodoki et al, by comparison free lutein or lutein-loaded NPs administered orally or topically in selenite cataract, demonstrated that the severity of lens injury was significantly reduced in rats treated with topical applications of lutein-loaded NPs [22]. Recently, it was demonstrated that in diabetic cataract, autoregenerative redox nanoparticles can act as an antioxidant and glycation inhibitor [23].…”

Section: Resultsmentioning

confidence: 99%

The ocular protective effects of PLGA nanoparticles loaded with lutein, in fat diet Wistar rats, treated with sistemic glucocorticoids

Dinu¹,

Pharmacy²,

Vîrgolici³

et al. 2020

Ro J Med Pract.

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Introduction. The carotene lutein is found in ocular layers and has powerful antioxidant, anti-inflammatory and anticarcinogenic properties. Posterior subcapsular cataract develops after prolonged glucocorticoid use. Poly(lactic-co-glycolic acid) nanoparticles (PLGA-NPs) is one of the most successfully developed biodegradable polymer used as antioxidant delivery system. The purpose of our study was to evaluate the ocular protective effects of PLGA-NPs loaded with lutein, in Wistar rats, on fat diet, treated with systemic glucocorticoids. Materials and methods. Healty Wistar male rats (n= 25, 12 months aged) were divided in 5 equal groups. the control group (S) with standard diet and no treatment and groups with Prednison treatment (1 mg/kg body weight), with and without PLGA-NPs loaded with lutein (1 mg/kg body weight), fed either with standard or fat diet. The duration of treatment was 6 weeks and it was done by gavaje. The eye examination was done by two ophtalmologists as a blind test and photos of the eyes were made. Serum metabolic parameters were measured. The rats treated with Prednison developed cataract and uveitis and the most severe injured eye was observed in the group with high caloric fat diet and no lutein as a supplement. Also, Prednison treatment produced dysglycaemia and dyslipidemia. The co-administration of lutein as PLGA-NPs with Prednison prevented the lens, retina and choroidal injuries, reduced the increased levels of glycaemia, triglyceridemia and increased the serum total antioxidant capacity. Conclusion. The PLGA lutein nanoparticles assured global eye protection, reducing the ocular side effects of prednison.

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Section: Resultsmentioning

confidence: 99%

The ocular protective effects of PLGA nanoparticles loaded with lutein, in fat diet Wistar rats, treated with sistemic glucocorticoids

Dinu¹,

Pharmacy²,

Vîrgolici³

et al. 2020

Ro J Med Pract.

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“…Thus, a current study successfully formulated poly lactic-coglycolic acid (PLGA) nanoparticles of lutein which can improve lutein's bioavailability. 60 In this review, we highlighted the comprehensive literature reports on chemical and biological properties of lutein. However, for determining the causality of these associations, additional research and randomised, controlled trials are needed.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, its improved oral formulation should be investigated. In a recent study, Bodoki et al 60 has successfully developed a medium in enhancing the bioavailability of lutein, which is lutein Poly(lacticco-glycolic acid) (PLGA) nanoparticles (NPs). The release profile of lutein from PLGA NPs suspended in phosphate buffered saline showed that the majority of lutein (~70%) trapped in PLGA NPs were released within the first 48 h. Additionally, the diffusion assessments confirmed the movement of the embodied nano-trapped lutein across semipermeable membranes into the bio-adhesive, thermosensitive hydrogel.…”

Section: Improved Formulations Of Luteinmentioning

confidence: 99%

“…However, lutein permeation is significantly restricted by the low water solubility of the antioxidant, which reaches a stable state within 24 h. The dependence of lutein's transfer rate on the cellulose membrane pore size suggests a bioactive permeation that is assisted by micelles. 60 It was anticipated that the inclusion of different types of nano-trapped lutein in thermosensitive bio-adhesive hydrogel may increase permeation into the eyes by extending the residence period at the administration site while retaining the bioactive form of the antioxidant. 60 Huang et al 61 prepared microspheres of lutein-alginate using a calcium chloride gelation process to boost the antioxidant capabilities of lutein.…”

Section: Improved Formulations Of Luteinmentioning

confidence: 99%

“…60 It was anticipated that the inclusion of different types of nano-trapped lutein in thermosensitive bio-adhesive hydrogel may increase permeation into the eyes by extending the residence period at the administration site while retaining the bioactive form of the antioxidant. 60 Huang et al 61 prepared microspheres of lutein-alginate using a calcium chloride gelation process to boost the antioxidant capabilities of lutein. Experiments on in-vitro release found that under acidic conditions, the microspheres presented slower releases than under neutralintestinal conditions.…”

Section: Improved Formulations Of Luteinmentioning

confidence: 99%

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Lutein: A Comprehensive Review on its Chemical, Biological Activities and Therapeutic Potentials

Fuad¹,

Sekar²,

Gan³

et al. 2020

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To complete this review, relevant literatures were collected from several scientific databases, include Google Scholar, Pubmed and ScienceDirect between 2000 to till date. The categories of keywords used were "Lutein" and "Sources" or "Pharmacological Studies" or "Molecular Mechanism" or "Biological Properties" or "Chemistry" or "Food Industry" or "Food Products" or "Formulations" or "Health Benefits". Studies which are not written in English and have no abstracts have been excluded from initial screening. There was no restriction to be followed for collecting the lutein-related studies, particularly in animal and human studies. After applying the inclusion and exclusion criteria and removing duplicates from the ABSTRACT Background: Lutein is a naturally occurring carotenoid found in high amounts in flowers, grains, fruits and green vegetables with green leaves include spinach, kale and carrots. The market for lutein encompasses pharmaceutical, dietary supplement, food, animal and fish feed industries. Objective: The present review aimed to provide an updated and comprehensive analysis of lutein, including its chemistry, biological properties and therapeutic potentials. Methods: Relevant literatures were collected from several scientific databases, include Google Scholar, Pubmed and ScienceDirect between 2000 to till date. Following a detailed inclusion and exclusion screening process, the information obtained was summarized. Results: Information on the sources, chemistry and biological properties including antioxidant, anti-arthrisits, antiinflammatory, hepatoprotective, cardioprotective, anti-cataract, antidiabetic, anticancer and bone remodelling activities, as well as food industry processing for lutein were tabled. Lutein can be considered powerful antioxidants along with multifaceted molecular targets, such as NF-ҡB, PI3K/Akt, Nrf-2, HO-1 and SIRT-1 signaling pathways in various pathological conditions. Conclusion: The present review observe the chemical, pharmacological properties, in addition to the therapeutic potentials of lutein. It is hoped that the information can provide a good reference to aid in the development and utilization of lutein in phytopharmaceuticals and food industries.

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Lipid Nanocarriers for Dermal Delivery of Lutein

Kumar²,

Goyal³

et al. 2020

Nanomedicine for Bioactives

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Topical nanodelivery system of lutein for the prevention of selenite-induced cataract

Cited by 28 publications

References 53 publications

The ocular protective effects of PLGA nanoparticles loaded with lutein, in fat diet Wistar rats, treated with sistemic glucocorticoids

The ocular protective effects of PLGA nanoparticles loaded with lutein, in fat diet Wistar rats, treated with sistemic glucocorticoids

Lutein: A Comprehensive Review on its Chemical, Biological Activities and Therapeutic Potentials

Lipid Nanocarriers for Dermal Delivery of Lutein

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