Topical minoxidil improves congenital hypotrichosis caused by LIPH mutations

Abstract

DEAR EDITOR, Mutations in LIPH are one cause of autosomal recessive woolly hair/hypotrichosis (ARWH). 1 LIPH mutations are not uncommon and are found all over the world. In this report, we present four patients with ARWH with LIPH muta-

Mutational analysis of 29 patients with autosomal-recessive woolly hair and hypotrichosis: LIPH mutations are extremely predominant in autosomal-recessive woolly hair and hypotrichosis in Japan

“…In contrast, the present study demonstrated that 27 of 29 (93%) Japanese patients with ARWH had LIPH mutations as the cause of their ARWH. We previously reported 15 patients with ARWH having LIPH mutations . Altogether, among the 44 reported patients with ARWH with LIPH mutations, the c.736T>A mutation clearly predominates as the ARWH‐causing LIPH mutation (allele frequency 76%), followed by c.742C>A (allele frequency 18%) and others (TableS1; see Supporting Information).…”

Identification of factors contributing to phenotypic divergence via quantitative image analyses of autosomal recessive woolly hair/hypotrichosis with homozygous c.736T>ALIPHmutation

“…Spontaneous improvement observed in the children included in this study suggested that enlargement of fine hair shafts is possible. The effectiveness of topical minoxidil in ARWH/H with LIPH mutations, and other monogenic hair disorders, has been noted. Minoxidil promotes the induction of anagen from telogen by vascular endothelial growth factor and fibroblast growth factor 7 via the production of adenosine .…”

Botanical extracts in combination improve autosomal recessive woolly hair/hypotrichosis caused by LIPH mutations

“…There are some traditional strategies in the hair loss treatment such as minoxidil. It is widely used in the treatment of androgenic alopecia (AGA) and alopecia areata, and some studies reported that topical minoxidil could improve ARWH 2,3 . In addition, some regenerative strategies can improve hair re‐growth (HR‐G) in patients with AGA such as platelet‐rich plasma (PRP), human hair follicle stem cells (HFSCs), micro‐needling technique (MN‐T), and low‐level laser therapy (LLL‐T) 7‐10 .…”

“…Mutation in the lipase H (LIPH) gene is a main reason for autosomal recessive woolly hair (ARWH)/ hypotrichosis 1 . Although some studies reported that topical minoxidil could improve ARWH, 2,3 an effective treatment method for this disease is still lacking. In this paper, we reported a case of hair growth in an ARWH patient with a LIPH gene mutation, using combined treatment of botanical extracts, and attempted to explore potential treatment options for ARWH.…”