Topical metronidazole application as an adjunct to scaling and root planing

Abstract

The results show that only minor advantages are to be gained from the application of a metronidazole 25% dental gel as adjunctive therapy to subgingival scaling. The distinctly better results of combined therapy in previously-untreated patients calls for more thorough investigation.

Clinical, Microbiologic, and Biochemical Effects of Subgingival Administration of a Xanthan‐Based Chlorhexidine Gel in the Treatment of Periodontitis: A Randomized Multicenter Trial

“…To overcome these limitations, local delivery systems containing antibiotic or antiseptic agents have been implemented. In particular, the local delivery of antimicrobial agents has been tested alone 12–15 and in combination with SRP 16–19 . As reviewed by Greenstein, 20 the local delivery of drugs generally enhanced the results achieved with mechanical treatment, although these improvements were usually limited.…”

Di̇ştaşlari Temi̇zli̇ği̇, Kök Yüzeyi̇ Düzleşti̇rmesi̇ Ve Poli̇sajda Güncel Kavramlar: Derleme

“…2,3 Subgingival tedavi sonrası gram (-) bakteri oranı azalırken gram (+) rodlar ve koklarda artış gözlemlenir. Gram (+) mikroorganizmaların etkin olduğu bu durum dişeti sağlığının göstergesidir 4 . Plağa bağlı gingivitis oral hijyenin önlemleriyle iyileştirilebilir ama enfeksiyon semente ulaştığında sorun sadece plak eliminasyonuyla çözülemez, mutlaka kök yüzeyi düzleştirmesi (root planing) işlemi yapılması gerekir 5,6 .…”

The Microbial Aetiology of Periodontal Diseases

“…Vibrios and spirochaetes are present in low numbers if at all (Dalwai et al, 2006;Grossi et al, 1994;Kumar et al, 2003;Listgarten & Helldén, 1978;Loesche, 1980;Marsh, 1994;Rosan & Lamont, 2000). Direct darkfield and phase contrast microscopic counts from healthy sites also indicate that spirochaetes (1-3%) and motile rods (1-6%) are present in low numbers, while coccoid cells (62-79%) predominate (Lindhe et al, 1980;Addy et al, 1983;Africa et al, 1985b;Adler et al, 1995;Stelzel et al, 2000). Studies of healthy sites following treatment also show similar low counts of these forms due to their reduction or complete elimination, with a concomitant increase in cocci (Listgarten et al 1978;Loesche et al 1987;Africa et al, 1985b;Adler et al, 1995;Stelzel et al, 2000).…”

“…Direct darkfield and phase contrast microscopic counts from healthy sites also indicate that spirochaetes (1-3%) and motile rods (1-6%) are present in low numbers, while coccoid cells (62-79%) predominate (Lindhe et al, 1980;Addy et al, 1983;Africa et al, 1985b;Adler et al, 1995;Stelzel et al, 2000). Studies of healthy sites following treatment also show similar low counts of these forms due to their reduction or complete elimination, with a concomitant increase in cocci (Listgarten et al 1978;Loesche et al 1987;Africa et al, 1985b;Adler et al, 1995;Stelzel et al, 2000). In the section that follows, the association of microbial species with periodontal diseases will be discussed according to the classification outlined in the World Workshop Proceedings (Armitage, 1999) and will be restricted to a selection of the species most frequently associated with periodontal diseases.…”