Topical methotrexate 1% gel for treatment of vitiligo: A case report and review of the literature

Abdelmaksoud, Ayman; Dave, Dharmendra Dineshchandra; Lotti, Torello; Vestita, Michelangelo

doi:10.1111/dth.13013

Cited by 14 publications

(11 citation statements)

References 15 publications

(19 reference statements)

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“…MTX is a folate antagonist that appears to decrease the number of T cells producing TNF-α, consequently having anti-inflammatory, immunomodulatory and antiproliferative effects (54). In a recent case report (54) in a patient with stable vitiligo, significant repigmentation was observed following treatment with topical MTX 1% gel applied twice daily for 12 weeks, along with folic acid supplementation. No side effects were reported.…”

Section: Methotrexate (Mtx)mentioning

confidence: 99%

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Updates and new medical treatments for vitiligo (Review)

et al. 2021

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Vitiligo is a multifactorial disease characterized by the loss of skin pigment, which results in achromic macules and patches. There are currently several medical treatments available, which aim to arrest progression and induce skin repigmentation. These treatments alone or combined have exhibited varying degrees of pigmentation, and the majority are safe and effective. All therapies for vitiligo are limited, and no known treatment can consistently produce repigmentation in all patients. Individualized treatment is appropriate according to the location, clinical presentation and the presence of disease activity. The present review summarizes the medical treatments available for vitiligo: Systemic and topic pharmacological therapies, physical and depigmentation treatments. Several treatments are still underway and have not yet been approved. However, due to the promising preliminary results, these are also mentioned in the present review. Contents 1. Introduction 2. Pharmacological treatment 3. Physical therapy 4. Depigmentation therapies 5. Conclusions

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Section: Methotrexate (Mtx)mentioning

confidence: 99%

“…No side effects were reported. However, further studies are required to determine the efficacy and safety of MTX (54).…”

Section: Methotrexate (Mtx)mentioning

confidence: 99%

Updates and new medical treatments for vitiligo (Review)

et al. 2021

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“…Furthermore, case reports and studies using oral MTX in vitiligo reported variable results, including arrested progression, marked skin repigmentation or no significant changes, and when MTX was compared with oral dexamethasone minipulse, both were considered equally effective (67)(68)(69)(70). Recently, a topical formula of MTX was used in a case report with significant improvement in repigmentation of the vitiligo lesion (71). However, further studies are required.…”

Section: Immunopathogenesis Of Vitiligomentioning

confidence: 99%

Novel immunological and genetic factors associated with vitiligo: A review

et al. 2021

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Vitiligo is a skin disorder characterized by depigmentation of the skin due to a lack of melanin. This condition affects men and woman of all ages and its incidence is not restricted by ethnicity or region. Vitiligo is a multifactorial disease, in which melanocytes, which serve important functions in skin pigmentation and immune processes, are impaired. There is sufficient evidence that immunological and genetic factors are primarily responsible for the destruction and dysfunction of melanocytes. Therefore, genetic DNA sequence variants that participate in skin homeostasis, pigmentation and immune response regulation, as well as altered expression patterns, may contribute to the risk of developing vitiligo. The current review presented an overview of the mechanism of pigmentation and of currently known factors involved in depigmentation, as well as the classification, epidemiology, associated comorbidities, risk factors, immunopathogenesis and several genetic and molecular changes associated with vitiligo. Contents 1. Overview 2. Immunopathogenesis of vitiligo 3. Genetic factors associated with vitiligo 4. Conclusions

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“…45 Furthermore, topical methotrexate 1% gel twice daily for 12 weeks has been used in one study with significant improvement of the lesion and no local or systemic side effects. 46 …”

Section: Medical Therapymentioning

confidence: 99%

Vitiligo: What’s old, what’s new

et al. 2021

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Vitiligo is an acquired pigmentary disorder afflicting 0.5-2% of the world population for both sexes and all races with a capricious and unpredictable course. It has a complex etiology and varies in its manifestation, progression and response to treatment. Even if the precise aetiology and pathobiology of the disease are complex and still debated, recent evidence supports that vitiligo is a T CD8+ cell-mediated autoimmune disease triggered by oxidative stress. To date no clinical, biological and histological criteria allow us to establish the prognosis with certainty. The choice of the best therapy for adult and childhood vitiligo is based on various factors, such as the patient’s age, psychological condition and expectations, distribution and extension of skin lesions, type of vitiligo (stable or not) and availability and cost of therapeutic options. Since vitiligo has a deep psychological impact on patients and their quality of life, treating the disease is very important. As dermatologists, we have important goals in the treatment of vitiligo patients: stabilization of the disease progression, repigmentation of the lesions and especially the persistence of the aforementioned repigmentation. Although several medical and surgical therapeutic options have been proposed, no definite cure has yet been developed and the long-term persistence of repigmentation is unpredictable. We review the different therapeutic options with particular attention on the recurrence rate.

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Topical methotrexate 1% gel for treatment of vitiligo: A case report and review of the literature

Cited by 14 publications

References 15 publications

Updates and new medical treatments for vitiligo (Review)

Updates and new medical treatments for vitiligo (Review)

Novel immunological and genetic factors associated with vitiligo: A review

Vitiligo: What’s old, what’s new

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