Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea

Wu, Jashin J.; Weinstein, Gerald D.; Kricorian, Greg; Kormeili, Tanya; McCullough, Jerry L.

doi:10.1111/j.1365-2230.2007.02513.x

Cited by 35 publications

(20 citation statements)

References 10 publications

(24 reference statements)

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“…It has been extensively used as growth promoting hormone in plant tissue culture systems [1, 2] but the potential effects of kinetin on human health are still under research. Some studies reported an effect of kinetin on human disorders or diseases [5–8]. Examples are prevention of age-related changes in human skin, presumably by protecting the DNA in skin cells from damage and by decreasing skin water loss [5, 8] as well as the therapeutic potential of kinetin in the treatment of the human splicing disease familial dysautonomia, a genetic disorder affecting the nervous system [6, 9].…”

Section: Introductionmentioning

confidence: 99%

The Plant Hormone Cytokinin Confers Protection against Oxidative Stress in Mammalian Cells

et al. 2016

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Modulating key dynamics of plant growth and development, the effects of the plant hormone cytokinin on animal cells gained much attention recently. Most previous studies on cytokinin effects on mammalian cells have been conducted with elevated cytokinin concentration (in the μM range). However, to examine physiologically relevant dose effects of cytokinins on animal cells, we systematically analyzed the impact of kinetin in cultured cells at low and high concentrations (1nM-10μM) and examined cytotoxic and genotoxic conditions. We furthermore measured the intrinsic antioxidant activity of kinetin in a cell-free system using the Ferric Reducing Antioxidant Power assay and in cells using the dihydroethidium staining method. Monitoring viability, we looked at kinetin effects in mammalian cells such as HL60 cells, HaCaT human keratinocyte cells, NRK rat epithelial kidney cells and human peripheral lymphocytes. Kinetin manifests no antioxidant activity in the cell free system and high doses of kinetin (500 nM and higher) reduce cell viability and mediate DNA damage in vitro. In contrast, low doses (concentrations up to 100 nM) of kinetin confer protection in cells against oxidative stress. Moreover, our results show that pretreatment of the cells with kinetin significantly reduces 4-nitroquinoline 1-oxide mediated reactive oxygen species production. Also, pretreatment with kinetin retains cellular GSH levels when they are also treated with the GSH-depleting agent patulin. Our results explicitly show that low kinetin doses reduce apoptosis and protect cells from oxidative stress mediated cell death. Future studies on the interaction between cytokinins and human cellular pathway targets will be intriguing.

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Section: Introductionmentioning

confidence: 99%

The Plant Hormone Cytokinin Confers Protection against Oxidative Stress in Mammalian Cells

et al. 2016

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“…45 Another topical therapy that has been shown to help restore the skin's barrier is kinetin, a plant cytokinin that is available as a 0.1% lotion. 46 The Chinese herb Chibixiao has also been found helpful in the treatment of rosacea in at least one trial. 47 In addition, patients with rosacea should be counseled to adhere closely to their therapy, and to avoid triggering factors.…”

Section: Oral Therapy Antibioticsmentioning

confidence: 99%

A Review of the Diagnosis and Treatment of Rosacea

Scheinfeld

Berk

2010

Postgraduate Medicine

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Rosacea is a common chronic inflammatory disease of the skin and is associated with a number of etiological causes and inciting factors. It is characterized by erythematous changes of the facial skin, and commonly presents with papules, pustules, or telangiectasias. The 4 subtypes of rosacea are categorized according to secondary symptoms, such as pain, erythema, dryness, and edema. A number of therapies are available to treat rosacea, some of which can be used in combination. The mainstays of therapy are topical metronidazole, topical azelaic acid, and oral tetracyclines. Other pharmacotherapeutic interventions have been shown to improve the signs and symptoms of rosacea, although many of these have not yet received approval by the US Food and Drug Administration for this indication.

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“…The applications for such adjuvant treatments are subtypes 1 and 2 [48,49]. Some open questions remain.…”

Section: Treatment Of Rosaceamentioning

confidence: 99%

Recent advances in the understanding and management of rosacea

Wollina¹

2014

F1000Prime Rep

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Rosacea is a chronic relapsing inflammatory facial dermatosis. There are several known triggers but the pathogenesis remains unknown. Recent achievements in understanding this disease point to the importance of skin-environmental interactions. This includes physical and chemical factors, but also microbial factors. The impairment of the skin barrier function and the activation of the innate immune defences are major and connected pathways contributing to an ongoing inflammatory response in the affected skin. This becomes modulated by endogenous factors like neurovascular, drugs, and psychological factors. These factors offer new therapeutic targets for rosacea treatment. There is a broader range of anti-inflammatory compounds available with a favourable safety record. Only recently have persistent erythema and flushing been addressed by new drug formulations.

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Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea

Cited by 35 publications

References 10 publications

The Plant Hormone Cytokinin Confers Protection against Oxidative Stress in Mammalian Cells

The Plant Hormone Cytokinin Confers Protection against Oxidative Stress in Mammalian Cells

A Review of the Diagnosis and Treatment of Rosacea

Recent advances in the understanding and management of rosacea

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