A Review of the Diagnosis and Treatment of Rosacea

Scheinfeld, Noah; Berk, Thomas

doi:10.3810/pgm.2010.01.2107

Cited by 36 publications

(33 citation statements)

References 38 publications

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“…The natural history of rosacea is unknown and progression within and between subtypes has been implied. [25][26][27][28] In this study, progression between subtypes was addressed by surveying subjects with rosacea about the order of appearance of rosacea-associated signs and symptoms by retrospective recall. We found that, despite a prolonged duration of rosacea with a mean of 21 years (median 20 years), the majority of subjects with ETR (69%) did not fulfil the criteria for PPR.…”

Section: Discussionmentioning

confidence: 99%

An observational cross-sectional survey of rosacea: clinical associations and progression between subtypes

et al. 2013

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Section: Discussionmentioning

confidence: 99%

An observational cross-sectional survey of rosacea: clinical associations and progression between subtypes

et al. 2013

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“…However, these studies do not agree on the exact target/binding site of the tetracyclines on the 16S rRNA (12). In addition, there is increasing evidence of other useful properties of the tetracyclines, such as their antiviral (2,13,14), anti-inflammatory (4,15), antiapoptotic (2), and neuroprotective activities (1), that are not explained by the 16S rRNA binding mechanism currently held for the antibacterial action of the tetracyclines.…”

mentioning

confidence: 96%

rRNA Binding Sites and the Molecular Mechanism of Action of the Tetracyclines

Chukwudi

2016

Antimicrob Agents Chemother

133

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The tetracycline antibiotics are known to be effective in the treatment of both infectious and noninfectious disease conditions. The 16S rRNA binding mechanism currently held for the antibacterial action of the tetracyclines does not explain their activity against viruses, protozoa that lack mitochondria, and noninfectious conditions. Also, the mechanism by which the tetracyclines selectively inhibit microbial protein synthesis against host eukaryotic protein synthesis despite conservation of ribosome structure and functions is still questionable. Many studies have investigated the binding of the tetracyclines to the 16S rRNA using the small ribosomal subunit of different bacterial species, but there seems to be no agreement between various reports on the exact binding site on the 16S rRNA. The wide range of activity of the tetracyclines against a broad spectrum of bacterial pathogens, viruses, protozoa, and helminths, as well as noninfectious conditions, indicates a more generalized effect on RNA. In the light of recent evidence that the tetracyclines bind to various synthetic double-stranded RNAs (dsRNAs) of random base sequences, suggesting that the double-stranded structures may play a more important role in the binding of the tetracyclines to RNA than the specific base pairs, as earlier speculated, it is imperative to consider possible alternative binding modes or sites that could help explain the mechanisms of action of the tetracyclines against various pathogens and disease conditions.

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“…Therefore, it is essential to be aware of the presence of rosacea to appropriately treat ocular surface disease that is not responding as expected to topical therapy 6 10 11. Indeed, our patient, who had previously received several topical treatments with a poor response, improved with a 2-month course of oral doxycycline.…”

Section: Discussionmentioning

confidence: 89%

Ocular rosacea: an underdiagnosed cause of relapsing conjunctivitis-blepharitis in the elderly

2014

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Red eye and relapsing conjunctivitis-blepharitis are among the most common ocular disease in elderly patients. In these cases the search for causes is difficult and frustrating. We report the case of a 79-year-old woman with a long history of red eye and relapsing conjunctivitis-blepharitis caused by ocular rosacea. In this patient the proper diagnosis was performed after 10 years of ocular disease, and repeated evaluations by general practitioners and clinical specialists, only after the appearance of facial signs of erythematotelangiectatic rosacea. Adequate therapy with oral doxycycline led to the improvement of the clinical picture that previously had shown a poor response to several topical treatments. The possibility of ocular rosacea should be considered in evaluating an elderly patient with persistent red eye and relapsing conjunctivitis-blepharitis. Making the proper diagnosis is crucial because ocular rosacea does not respond as expected to topical therapy and may lead to severe corneal involvement.

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A Review of the Diagnosis and Treatment of Rosacea

Cited by 36 publications

References 38 publications

An observational cross-sectional survey of rosacea: clinical associations and progression between subtypes

An observational cross-sectional survey of rosacea: clinical associations and progression between subtypes

rRNA Binding Sites and the Molecular Mechanism of Action of the Tetracyclines

Ocular rosacea: an underdiagnosed cause of relapsing conjunctivitis-blepharitis in the elderly

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