Topical Hyperbaric Oxygen Therapy Versus Local Ozone Therapy in Healing of Venous Leg Ulcers

Abstract

Background: the treatment of venous leg ulcers still poses a difficult interdisciplinary medical problem. The aim of this study was to compare the therapeutic efficacy of local hyperbaric oxygen therapy with local ozone therapy in the treatment of venous leg ulcers. Materials: this study included 114 patients; 60 males (52.63%) and 54 females (47.36%) of ages ranging between 39 and 88 years (mean age: 68.9 ± 9.8 years) with venous leg ulcers, who underwent topical hyperbaric oxygen therapy (group I) and local ozone therapy (group II). In each of the study groups, the patients underwent 30 therapeutic procedures lasting 30 min each. The progress in wound healing was evaluated by computerized planimetry, and the intensity of pain was assessed with the use of the Visual Analogue Scale (VAS). Results: in both groups of treated patients, a statistically significant (p = 0.000001) reduction in the area of treated ulcers was achieved. In group I, the wound area decreased by an average of 69.67 ± 22.52%, from 7.55 ± 2.99 cm2 to 2.78 ± 2.43 cm2, and in group II, by an average of 41.33 ± 21.31%, from 7.36 ± 2.82 cm2 to 4.62 ± 2.76 cm2. In both groups of patients, a statistically significant (p = 0.000001) reduction in the intensity of pain ailments was observed: in group I, by an average of 0.55 ± 0.54 points, and in group II, by an average of 2.33 ± 0.82 points on the VAS scale. Conclusions: local hyperbaric oxygen therapy and local ozone therapy cause a statistically significant reduction in the surface area of venous leg ulcers as well as in the intensity of pain. Better results were observed after the application of local hyperbaric oxygen therapy procedures.

A Multiple Synergic Treatment for Non-Healing Ulcer Management in a Patient with Klippel–Trenaunay Syndrome

“…Furthermore, red blood cells become more flexible, increasing oxygen arrival to tissues, and accelerating wound healing. The analgesic effect may be obtained through the activation of opioid system, and the expression of antioxidant and chemotactic factors, and the reduction in pro-inflammatory cytokines [22].…”

“…More recently, in 114 patients with venous leg ulcers, Pasek et al [22] compared effects of topical hyperbaric oxygen versus topical oxygen-ozone and documented that both treatments improved clinical symptoms.…”

Oxygen Therapy to Enhance Wound Healing After Revascularization

“…Local HBOT treatment is the new treatment for diabetic foot ulcer (DFU) and venous leg ulcers first published by Pasek J. et al in 2022 and 2023. 52,53 It reported promising results in wound area and pain reduction. However, the data on this new treatment in postrevascularization ulcers is unavailable.…”