Topical Grape Seed Proanthocyandin Extract Reduces Sunburn Cells and Mutant p53 Positive Epidermal Cell Formation, and Prevents Depletion of Langerhans Cells in an Acute Sunburn Model

Yuan, Xiao-Ying; Liu, Wei; Hao, Jianchun; Gu, Weijie; Zhao, Yan-Shuang

doi:10.1089/pho.2011.3043

Cited by 20 publications

(7 citation statements)

References 21 publications

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“…In contrast, GSPs enhanced the production of immune stimulatory cytokine IL-12 in the draining lymph nodes. GSPs fed mice exhibit a reduction in UV-induced suppression of allergic contact hypersensitivity, a prototypic T-cell-mediated response [51]. Results suggest that GSPs prevent UVB-induced immunosuppression through DNA repair dependent functional activation of dendritic cells and reexpression of tumor suppressor genes RASSF1A , p16INK4a , and Cip1/p21 .…”

Section: Skin Cancer Chemoprevention By Using Phytochemicals: Mechmentioning

confidence: 99%

New Enlightenment of Skin Cancer Chemoprevention through Phytochemicals:In VitroandIn VivoStudies and the Underlying Mechanisms

Singh

Suman

Shukla

2014

BioMed Research International

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Skin cancer is still a major cause of morbidity and mortality worldwide. Skin overexposure to ultraviolet irradiations, chemicals, and several viruses has a capability to cause severe skin-related disorders including immunosuppression and skin cancer. These factors act in sequence at various steps of skin carcinogenesis via initiation, promotion, and/or progression. These days cancer chemoprevention is recognized as the most hopeful and novel approach to prevent, inhibit, or reverse the processes of carcinogenesis by intervention with natural products. Phytochemicals have antioxidant, antimutagenic, anticarcinogenic, and carcinogen detoxification capabilities thereby considered as efficient chemopreventive agents. Considerable efforts have been done to identify the phytochemicals which may possibly act on one or several molecular targets that modulate cellular processes such as inflammation, immunity, cell cycle progression, and apoptosis. Till date several phytochemicals in the light of chemoprevention have been studied by using suitable skin carcinogenic in vitro and in vivo models and proven as beneficial for prevention of skin cancer. This revision presents a comprehensive knowledge and the main molecular mechanisms of actions of various phytochemicals in the chemoprevention of skin cancer.

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Section: Skin Cancer Chemoprevention By Using Phytochemicals: Mechmentioning

confidence: 99%

New Enlightenment of Skin Cancer Chemoprevention through Phytochemicals:In VitroandIn VivoStudies and the Underlying Mechanisms

Singh

Suman

Shukla

2014

BioMed Research International

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“…The creams developed from grape seed extracts were considered safe and nonirritating to the skin in the Burchard test [67]. Skin treated with grape seed extract before UV exposure showed less p53 mutant cells and more epidermal cells and Langerhans cells compared to untreated skin [68], suggesting greater protection of the human genome against photoaging, mutations, and skin cancer [69]. A study carried out with 22 winegrowers showed a weak positive reaction in six individuals who worked directly on grapevines.…”

Section: Discussionmentioning

confidence: 99%

Safety and Photoprotective Efficacy of a Sunscreen System Based on Grape Pomace (Vitis vinifera L.) Phenolics from Winemaking

et al. 2020

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In winemaking, a large amount of grape pomace is produced that is rich in polyphenolics and highly beneficial for human health, as phenols are useful for skin ultraviolet (UV) protection. In this investigation, we evaluated the safety and clinical efficacy of a sunscreen system containing a grape pomace extract from Vitis vinifera L. as a bioactive ingredient. The recovery of phenolics in the waste was performed by percolation. Nine emulsions were developed using a factorial design and two were evaluated clinically: Formulation E, containing only UV filters (butylmethoxydibenzoyl methane, ethylhexyl methoxycinnamate and ethylhexyl dimethyl PABA), and F, with the extract at 10.0% w/w + UV filters. The antioxidant activity was determined by the DPPH assay and the in vitro efficacy was established by sun protection factor (SPF) measurements (Labsphere UV-2000S). Clinical tests were performed to determine safety (human repeated insult patch test) and to confirm efficacy (photoprotective effectiveness in participants). The results showed a synergistic effect between the sunscreen system and the extract on UVB protection and antioxidant activity. Both samples were considered safe. Formulation F was 20.59% more efficient in protecting skin against UVB radiation, taking approximately 21% more time to induce erythema compared to the extract-free sample.

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“…Proanthocyanidins are effective antioxidants and anti-inflammatory agents found in particularly high concentrations in grapes (GSPs) [60]. GSPs have been found to reduce UV skin damage, like photo-aging, and to decrease melanin synthesis [121, 122]. .In humans, GSPs have been shown to reduce mutant p53-positive epidermal cells and prevent the depletion of Langerhans cells after sunburns.…”

Section: Nutrients/phytochemicals and Melanomamentioning

confidence: 99%

Dietary compounds and cutaneous malignant melanoma: recent advances from a biological perspective

et al. 2019

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Cutaneous malignant melanoma is a heterogeneous disease, being the consequence of specific genetic alterations along several molecular pathways. Despite the increased knowledge about the biology and pathogenesis of melanoma, the incidence has grown markedly worldwide, making it extremely important to develop preventive measures. The beneficial role of correct nutrition and of some natural dietary compounds in preventing malignant melanoma has been widely demonstrated. This led to numerous studies investigating the role of several dietary attitudes, patterns, and supplements in the prevention of melanoma, and ongoing research investigates their impact in the clinical management and outcomes of patients diagnosed with the disease. This article is an overview of recent scientific advances regarding specific dietary compounds and their impact on melanoma development and treatment.

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Topical Grape Seed Proanthocyandin Extract Reduces Sunburn Cells and Mutant p53 Positive Epidermal Cell Formation, and Prevents Depletion of Langerhans Cells in an Acute Sunburn Model

Abstract: GSPE may be a possible preventive agent for photoprotection.

Cited by 20 publications

References 21 publications

New Enlightenment of Skin Cancer Chemoprevention through Phytochemicals:In VitroandIn VivoStudies and the Underlying Mechanisms

New Enlightenment of Skin Cancer Chemoprevention through Phytochemicals:In VitroandIn VivoStudies and the Underlying Mechanisms

Safety and Photoprotective Efficacy of a Sunscreen System Based on Grape Pomace (Vitis vinifera L.) Phenolics from Winemaking

Dietary compounds and cutaneous malignant melanoma: recent advances from a biological perspective

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