Dietary compounds and cutaneous malignant melanoma: recent advances from a biological perspective

Ombra, Maria Neve; Paliogiannis, Panagiotis; Stucci, Luigia Stefania; Colombino, Maria; Casula, Milena; Sini, Maria Cristina; Manca, Antonella; Palomba, Grazia; Stanganelli, Ignazio; Mandalà, Mario; Gandini, Sara; Lissia, Amelia; Doneddu, Valentina; Cossu, Antonio; Palmieri, Giuseppe

doi:10.1186/s12986-019-0365-4

Cited by 15 publications

(16 citation statements)

References 152 publications

(158 reference statements)

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“…Pathological skin cells were selected for this research due to the awareness of problems resulting from unknown plant matrix metabolic pathways when used internally. Additionally, previous studies have suggested the anticancer potential of luteolin and its derivatives [ 6 , 31 , 32 , 33 ]. To the best of our knowledge, there are currently no reports in the literature on the effects of J. montana extracts and its main phytoconstituents on C32 cells.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Anticancer Potential of Jasione montana and Its Main Components against Human Amelanotic Melanoma Cells

Juszczak

Czarnomysy

Strawa

et al. 2021

IJMS

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Jasione montana L. (Campanulaceae) is used in traditional Belarusian herbal medicine for sleep disorders in children, but the chemical composition and biological activity have not been investigated. In this study, the activities of J. montana extracts, their fractions and main compounds were evaluated in amelanotic melanoma C32 (CRL-1585) cells and normal fibroblasts (PCS-201-012). The extracts and fractions were analyzed using liquid chromatography–photodiode array detection–electrospray ionization–mass spectrometry (LC–PDA–ESI–MS/TOF) to characterize 25 compounds. Further, three major and known constituents, luteolin (22) and its derivatives such as 7-O-glucoside (12) and 7-O-sambubioside (9) were isolated and identified. The cytotoxic activities against fibroblasts and the amelanotic melanoma cell line were determined using the fixable viability stain (FVS) assay. The influence of diethyl ether (Et2O) fraction (JM4) and 22 on apoptosis induction was investigated using an annexin V binding assay. The obtained results showed significant cytotoxicity of JM4 and 22 with IC50 values of 119.7 ± 3.2 and 95.1 ± 7.2 μg/mL, respectively. The proapoptotic potential after 22 treatment in the C32 human amelanotic melanoma cell line was comparable to that of vinblastine sulfate (VLB), detecting 29.2 ± 3.0% apoptotic cells. Moreover, 22 displayed less necrotic potential against melanoma cells than VLB. In addition, the influences of JM4 and 22 on the dysfunction of the mitochondrial membrane potential (MMP), cell cycle and activity of caspases 3, 8, 9, and 10 were established. The effects of JM4 on MMP change (74.5 ± 3.0% of the cells showed a reduced MMP) corresponded to the results obtained from the annexin V binding assay and activation of caspase-9. JM4 and 22 displayed a significant impact on caspase-9 (40.9 ± 2.4% of the cells contained active caspase-9 after JM4 treatment and 16.6 ± 0.8% after incubation with 22) and the intrinsic (mitochondrial) apoptotic pathway. Moreover, studies have shown that JM4 and 22 affect the activation of external apoptosis pathways by inducing the caspase-8 and caspase-10 cascades. Thus, activation of caspase-3 and DNA damage via external and internal apoptotic pathways were observed after treatment with JM4 and 22. The obtained results suggest that J. montana extracts could be developed as new topical preparations with potential anticancer properties due to their promising cytotoxic and proapoptotic potential.

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Section: Discussionmentioning

confidence: 99%

In Vitro Anticancer Potential of Jasione montana and Its Main Components against Human Amelanotic Melanoma Cells

Juszczak

Czarnomysy

Strawa

et al. 2021

IJMS

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Section: Discussionmentioning

confidence: 99%

“…Numerous diet‐derived phytochemicals such as epigallocatechin‐3‐gallate, resveratrol, curcumin, proanthocyanidins, silymarin, apigenin, capsaicin, genistein, indole‐3‐carbinol, and luteolin have shown promising chemopreventive effects in melanoma, due to their antioxidant property (Ombra et al, 2019). In addition, most of these molecules are safe, widely available, high tolerable, and cost‐effective, making them ideal agents to improve cancer chemoprevention and treatment.…”

Section: Introductionmentioning

confidence: 99%

“…A great number of studies have been published recently investigating the beneficial role of natural dietary compounds in the prevention and adjuvant effect in the therapy of malignant melanoma. Because of their general safety, low toxicity, and antioxidant properties, fruit, vegetables, and other dietary elements (phytochemicals and minerals) have been identified as chemopreventive agents(Ombra et al, 2019).In this study, we have screened a library of plant-derived sesquiterpene lactones in order to select compounds active in vitro against A375 melanoma cells. Obtained results indicated cynaropicrin, an abundant constituent of artichoke and of other numerous plants belonging to the Asteraceae (Compositae) family, as a promising hit.…”

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confidence: 99%

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Inhibitory effects of cynaropicrin on human melanoma progression by targeting MAPK, NF‐κB, and Nrf‐2 signaling pathways in vitro

Cicco

Busà

Ercolano

et al. 2020

Phytotherapy Research

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Malignant melanoma is the deadliest skin cancer, due to its propensity to metastasize. MAPKs and NF-κB pathways are constitutively activated in melanoma and promote cell proliferation, cell invasion, metastasis formation, and resistance to therapeutic regimens. Thus, they represent potential targets for melanoma prevention and treatment. Phytochemicals are gaining considerable attention for the management of melanoma because of their several cellular and molecular targets. A screening of a small library of sesquiterpenes lactones selected cynaropicrin, isolated from the aerial parts of Centaurea drabifolia subsp. detonsa, for its potential anticancer effect against melanoma cells. Treatment of human melanoma cells A375 with cynaropicrin resulted in inhibition of cell proliferation and induction of caspase-3-dependent apoptosis. Furthermore, cynaropicrin reduced several cellular malignant features such migration, invasion, and colonies formation through the inhibition of ERK1/2 and NF-κB activity. Cynaropicrin was able to reduce intracellular reactive oxygen species generation, which are involved in all the stages of carcinogenesis. Indeed, cynaropicrin increased the expression of several antioxidant genes, such as glutamate-cysteine ligase and heme oxygenase-1, by promoting the activation of the transcription factor Nrf-2. In conclusion, our results individuate cynaropicrin as a potential adjuvant chemotherapeutic agent for melanoma by targeting several protumorigenic signaling pathways.

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“…It is generally acknowledged that a healthy diet provides beneficial effect as preventive therapy against cancer. Dietary components of spices and food as curcumin, cinnamon, quercetin, resveratrol, lycopene and epigallocathechins interfere with the main molecular pathways of melanoma genesis [5] identifying suitable molecular framework on which design new drug candidates [6,7] . Although curcumin, the main component of Curcuma longa , shows to be extremely safe in animal and humans even at very high doses, it has not yet been approved as a therapeutic agent due to the poor solubility, stability at physiological level and low bioavailability (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Hydroxylated Biphenyl Derivatives Bearing an α,β‐Unsaturated Ketone as a Lead Structure for the Development of Drug Candidates against Malignant Melanoma

et al. 2021

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A small collection of C2‐symmetric hydroxylated biphenyl derivatives featuring an α,β‐unsaturated ketone as a lead structure was prepared, and the capacity of these compounds to act as antiproliferative agents against four human malignant melanoma cell lines was assayed. The prodrug approach was applied in order to improve the delivery of compounds into the cell by modulation of the phenolic hydroxy protecting group. The hydroxylated biphenyl structure bearing an α,β‐unsaturated ketone and a phenolic‐O‐prenylated chain was found to facilitate the delivery of the molecule and interactions with biological targets. Four compounds showed antiproliferative activity resulting in IC50 values in the range of 1.2 to 2.8 μM.

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Dietary compounds and cutaneous malignant melanoma: recent advances from a biological perspective

Cited by 15 publications

References 152 publications

In Vitro Anticancer Potential of Jasione montana and Its Main Components against Human Amelanotic Melanoma Cells

In Vitro Anticancer Potential of Jasione montana and Its Main Components against Human Amelanotic Melanoma Cells

Inhibitory effects of cynaropicrin on human melanoma progression by targeting MAPK, NF‐κB, and Nrf‐2 signaling pathways in vitro

Synthesis of Hydroxylated Biphenyl Derivatives Bearing an α,β‐Unsaturated Ketone as a Lead Structure for the Development of Drug Candidates against Malignant Melanoma

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