Topical glucocorticoids inhibit activation by allergen in the upper respiratory tract

Lozewicz, S.; Wang, Jiahua; Duddle, Judith; Thomas, K. J.; Chalstrey, S; Reilly, Gerard D.; Devalia, Jagdish L.; Davies, Robert J.

doi:10.1016/0091-6749(92)90217-p

Cited by 56 publications

(37 citation statements)

References 25 publications

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“…Effects of steroids on the immediate phase reaction of the nasal mucosa are controversial [8][9][10][11][12][13][14]. Okuda et al [13] used beclomethasone dipropionate (BDP) in patients with perennial nasal allergy for 2 weeks and reported a sta tistically significant decrease in the number of basophilic cells in the surface layer of the nasal mucosa, while there was no change in vitro histamine release rate from nasal basophilic cells induced by the antigen challenge.…”

Section: Effect O F Topical Steroids On the Immediate Phase Reaction mentioning

confidence: 99%

“…Increased numbers of acti vated eosinophils in the nasal mucosa in nasal late phase reaction after antigen challenge is thought to be closely as sociated with enhancement of nonspecific nasal reactivity in nasal allergy [5,6], although the role of eosinophils in enhancement of nasal reactivity is not yet clear [4]. Topical steroids have strong inhibitory effects on hyperreactive nasal symptoms in nasal allergy and also inhibit the influx of ECP in nasal lavages significantly [6,7], However, there are still controversies about the effects of topical steroids on the immediate allergic reaction [8][9][10][11][12][13] and on nonspe cific nasal hyperreactivity [11][12][13][14][15] in nasal allergy.…”

Section: Introductionmentioning

confidence: 99%

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Mode of Action of a Topical Steroid on Immediate Phase Reaction After Antigen Challenge and Nonspecific Nasal Hyperreactivity in Nasal Allergy

Konno

Yamakoshi

Terada

et al. 1994

Int Arch Allergy Immunol

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This study compared the effects of 2-week administration of a topical steroid (fluticasone propionate [FP] 100 μg twice daily) with placebo in 28 patients with perennial nasal allergy who were allergic to house dust and mites in a double-blind randomized study. The number of inflammatory cells and decidual epithelial cells and concentrations of tryptase and eosinophil cationic protein in nasal lavages, and reactivity of the nasal mucosa to histamine and to antigen were investigated. The topical steroid, FP, significantly inhibited all of these assessments. The degree of improvement of nasal reactivity to histamine significantly correlated with the degree of decrease in eosinophil cationic protein levels.

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Section: Effect O F Topical Steroids On the Immediate Phase Reaction mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mode of Action of a Topical Steroid on Immediate Phase Reaction After Antigen Challenge and Nonspecific Nasal Hyperreactivity in Nasal Allergy

Konno

Yamakoshi

Terada

et al. 1994

Int Arch Allergy Immunol

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“…Sections were counterstained with Meyer's haematoxylin. For negative controls, the primary antibodies were omitted and replaced by normal mouse serum as a control for the mouse mono-clonals as described previously [21]. Rat serum was used to control for α 6 β 1 -integrin (rat immunoglobulin-2 (IgG2α).…”

Section: Immunohistologymentioning

confidence: 99%

The expression of intercellular adhesion molecule-1 and the beta 1-integrins in asthma

Manolitsas

Trigg²,

McAulay³

et al. 1994

Eur Respir J

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T Th he e e ex xp pr re es ss si io on n o of f i in nt te er rc ce el ll lu ul la ar r a ad dh he es si io on n m mo ol le ec cu ul le e--1 1 a an nd d t th he e β1 1--i in nt te eg gr ri in ns s i in n a as st th hm ma a The aim of this study was to determine whether adhesion receptor expression was altered in human asthmatic bronchial epithelium. Using monoclonal antibody staining, we have examined the expression of ICAM-1 and the α 1 -α 6 -subunits of the β 1 -integrin family in bronchial mucosal biopsies from 33 asthmatic and 13 nonasthmatic subjects.The epithelium was positive for ICAM-1 in 26 out of 33 asthmatics, although negative in all 13 nonasthmatics. ICAM-1 expression was not associated with bronchial responsiveness or with medication requirements. Beta 1 -integrin staining showed that α 2 -, α 3 -and α 6 -subunits stained the epithelium in all cases. Alpha 4 staining was weakly positive in the epithelium in five asthmatics. Alpha 5 staining was weak in asthmatics and normals. Alpha 4 and α 6 -subunits also stained inflammatory cells.Epithelial upregulation of ICAM-1 is present in asthma. Beta 1 -integrins with α 2 -, α 3 -and α 6 -subunits appear to be constitutively expressed in bronchial epithelium.

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“…It also abolished antigen-induced eosinophil cationic protein measured in nasal lavage [21]. Such an action on eosinophils is indicative of a possible mechanism by which fluticasone may act to inhibit inflammatory cell recruitment and mediator production.…”

Section: Discussionmentioning

confidence: 80%

Effect of short‐term treatment with fluticasone propionate nasal spray on the response to nasal allergen challenge.

Austin

1994

Brit J Clinical Pharma

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Topical glucocorticoids inhibit activation by allergen in the upper respiratory tract

Cited by 56 publications

References 25 publications

Mode of Action of a Topical Steroid on Immediate Phase Reaction After Antigen Challenge and Nonspecific Nasal Hyperreactivity in Nasal Allergy

Mode of Action of a Topical Steroid on Immediate Phase Reaction After Antigen Challenge and Nonspecific Nasal Hyperreactivity in Nasal Allergy

The expression of intercellular adhesion molecule-1 and the beta 1-integrins in asthma

Effect of short‐term treatment with fluticasone propionate nasal spray on the response to nasal allergen challenge.

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