Effect of short‐term treatment with fluticasone propionate nasal spray on the response to nasal allergen challenge.

Gk, Scadding; Yc, Darby; Austin, C.E.

doi:10.1111/j.1365-2125.1994.tb04381.x

Cited by 13 publications

(4 citation statements)

References 16 publications

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“…For prostaglandins and chronic rhinitis the picture is less clear, with some studies failing to show an increase in prostaglandin levels 20 while others demonstrate a significant elevation. 21 It has been shown that porcine nasal mucosa is able to synthesize prostaglandins (particularly E 2 and D 2 ) and also inactivate them via the 15 hydroxy prostaglandin dehydrogenase and ⌬ 13 -reductase pathway. 4 These prostanoids can also be extracted from diced nasal mucosa in vitro.…”

Section: Discussionmentioning

confidence: 99%

Prostaglandins, leukotrienes and perennial rhinitis

2004

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Prostaglandins and leukotrienes are implicated in conditions of both the upper and lower airways. In the former they are deranged in nasal polyposis, intrinsic rhinitis and allergic rhinitis while in the latter they are involved in the pathogenesis of asthma. The aim of the present study was to measure mucosal eicosanoid levels in the three types of rhinitis and compare with controls. In addition, the effect of topical steroids on eicosanoid levels in rhinitis was examined. The levels of prostaglandins E(2) (PGE(2)) and D(2) (PGD(2)) and of leukotrienes E(4) (LTE(4)) and B(4) (LTB(4)) were measured in nasal biopsies from the inferior turbinates of patients suffering from perennial rhinitis and a control group. Rhinitis patients were classified into three categories: perennial allergic rhinitis (PAR), non-allergic rhinitis with eosinophilia (NARES) and noneosinophilic non-allergic rhinitis (NENAR) on the basis of symptoms, secretion eosinophilia, nasal resistance and allergy testing. Patients with rhinitis were randomized into two groups. One received fluticasone propionate nasal spray (FPANS) and the other a placebo (PNS) over a period of six weeks prior to the biopsies. One hundred and one patients with PAR, NARES or NENAR were recruited sequentially and the control group consisted of 21 patients with no evidence of rhinitis but with nasal obstruction due to septal deviation. Untreated rhinitics had significantly lower levels of PGE(2), PGD(2) and LTE(4) than non-rhinitic controls. Six-weeks' treatment with FPANS significantly increased the levels of those eicosanoids in patients with PAR and NARES but they were still significantly below normal. Levels of LTB(4) in all three rhinitis groups were not significantly different from controls and treatment with topical steroids had no effect. Their findings are contrary to current thinking that increased levels of eicosanoids, in particular cysteinyl-leukotrienes, play an important role in the pathogenesis of chronic, non-infective upper airway inflammation.

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Section: Discussionmentioning

confidence: 99%

Prostaglandins, leukotrienes and perennial rhinitis

2004

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“…Same authors found that after nasal provocation with an allergen, treatment with FP decreased obstruction in 45%, sneezing in 73%, pruritus in 78% and hydrorrhoea in 80% (Scadding et al, 1994). …”

Section: Fluticasone Propionatementioning

confidence: 90%

“…The speed of action is greater in fluticasone, as evidenced by the fact that significant improvement in symptoms is seen by the second day of treatment, while the delay in the onset of improvement for those treated with BDP was three days (Scadding et al, 1994).…”

Section: Fluticasone Propionatementioning

confidence: 95%

Treatment of Allergic Rhinitis: Anticholinergics, Glucocorticotherapy, Leukotriene Antagonists, Omalizumab and Specific-Allergen Immunotherapy

Palomo¹,

Bobolea²,

Gonzalez³

et al. 2012

Otolaryngology

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“…Δηδηθφηεξα, αχμεζε ηεο ΔΟΠ έρεη παξαηεξεζεί ζε ελδνθιέβηα, ζηνκαηηθή, ηνπηθή δεξκαηνινγηθή, νθζαικνινγηθή ή πεξηνθζαικηθή ζεξαπεία, θαζψο θαη κεηά απφ αγσγή κε θνξηηθνζηεξνεηδή (Radner et al, 1992, Opatowski, 1995. Ζ αλάπηπμε γιαπθσκαηηθήο νπηηθήο λεπξνπάζεηαο, ζπλνδεπφκελε απφ ζεκαληηθή απψιεηα ηνπ νπηηθνχ πεδίνπ θαη κεησκέλε νπηηθή νμχηεηα, έρεη επίζεο ζρεηηζηεί κε ηε ρξήζε ζηεξνεηδψλ νπζηψλ, ελψ αληίζηνηρεο δηαηαξαρέο παξαηεξήζεθαλ παξά ηε δηαθνπή ηεο ζεξαπεπηηθήο αγσγήο απφ ηνπο ζε ζρεηηθέο εξεπλεηηθέο εξγαζίεο (Scadding et al, 1994, Scadding et al, 1995.…”

Section: αμνληθή ηνκνγξαθία (Ct)unclassified

Μεταβολή Της Ενδοφθάλμιας Πίεσης Μετά Από Μακροχρόνια Χρήση Ρινικών Ψεκασμών

Σπηλιωτόπουλος¹

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Effect of short‐term treatment with fluticasone propionate nasal spray on the response to nasal allergen challenge.

Cited by 13 publications

References 16 publications

Prostaglandins, leukotrienes and perennial rhinitis

Prostaglandins, leukotrienes and perennial rhinitis

Treatment of Allergic Rhinitis: Anticholinergics, Glucocorticotherapy, Leukotriene Antagonists, Omalizumab and Specific-Allergen Immunotherapy

Μεταβολή Της Ενδοφθάλμιας Πίεσης Μετά Από Μακροχρόνια Χρήση Ρινικών Ψεκασμών

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