Topical estradiol increases epidermal thickness and dermal collagen of foreskin prior to hypospadia surgery – Randomized double blinded controlled trial

Casali, Thaís Gomes; Paiva, Kelly Christina de Castro; Rodrigues, Matheus Nehrer; Silva, C.E. Santana; Figueiredo, André Avarese de; Bessa, José de; Bastos, André Netto; Castañon, Maria Christina Marques Nogueira; Netto, José Murillo Bastos

doi:10.1016/j.jpurol.2019.05.014

Cited by 8 publications

(3 citation statements)

References 27 publications

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“…Casali et al and Paiva et al used topical testosterone propionate or topical estradiol. Paiva et al showed that the use of testosterone and estradiol resulted in a significant increase in penile length and penis circumference compared with the control group (10,14). Casali et al investigated the effect of the same regimen on the epidermal thickness and type I collagen expression, both of which were found to be significantly increased compared with the control group (10).…”

Section: Efficacy Of Preoperative Hormonal Stimulation In Hypospadiasmentioning

confidence: 99%

“…Paiva et al showed that the use of testosterone and estradiol resulted in a significant increase in penile length and penis circumference compared with the control group (10,14). Casali et al investigated the effect of the same regimen on the epidermal thickness and type I collagen expression, both of which were found to be significantly increased compared with the control group (10). de Andrade et al reported the use of topical testosterone propionate for 30 days, which resulted in increased serum testosterone concentrations up to 30 days post-therapy (17).…”

Section: Efficacy Of Preoperative Hormonal Stimulation In Hypospadiasmentioning

confidence: 99%

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Preoperative hormonal stimulation in hypospadias: a systematic review

Pramono¹,

Siregar²,

Sibarani³

2023

Ann Afr Surg.

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Introduction: Preoperative hormonal stimulation with testosterone or estrogen is an emerging treatment modality for hypospadias, which can potentially improve surgical outcomes and reduce the risk of complications. This review aims to evaluate the current knowledge on preoperative hormonal stimulation in hypospadias. Methods: This study was a combination of a systematic review followed by a meta-regression analysis performed on PubMed, Google Scholar, DOAJ, and Cochrane. The study included randomized controlled trials, prospective and retrospective cohort studies, and before-and-after studies with or without control. The search was performed in English and was limited to articles published between January 1, 2000, and December 31, 2020. Results: The database search yielded 188 articles, which were systematically eliminated, leaving 15 relevant articles. The analyzed articles showed that testosterone is the most commonly used hormonal treatment in hypospadias, followed by dihydrotestosterone (DHT) and estrogen. Testosterone may be given in topical, parenteral, or oral formulations, while DHT is most often used in topical form. Conclusions: Preoperative stimulation with testosterone or DHT is associated with increased penile length and glans circumference before surgery, which may ease the reconstruction process. In addition, testosterone and DHT increase the rate of neovascularization and reduce the risk of postoperative complications.

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Section: Efficacy Of Preoperative Hormonal Stimulation In Hypospadiasmentioning

confidence: 99%

Section: Efficacy Of Preoperative Hormonal Stimulation In Hypospadiasmentioning

confidence: 99%

Preoperative hormonal stimulation in hypospadias: a systematic review

Pramono¹,

Siregar²,

Sibarani³

2023

Ann Afr Surg.

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“…Growth in genital organs as a result of increased androgenic effect with puberty may have increased microvessel density, which was found to be low in the group with hypospadias in childhood (Cagri Savas et al, 2011). In this case, it may be evaluated that topical testosterone and oestrogen applications (Casali et al, 2019) before surgery may not be necessary in childhood. Although no statistical difference was found in our study, the severity of inflammation was found to be high in the hypospadias group.…”

Section: F I G U R Ementioning

confidence: 99%

Is primary adult hypospadiatic prepuce different from healthy prepuce in terms of microvascular density and androgen‐estrogen‐progesterone receptors?

Yeşildal¹,

Yılmaz²,

Akan³

et al. 2020

Andrologia

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Hypospadias is the most common congenital malformation of the penis, which is defined as the termination of the external urethral meatus at a more proximal level on the ventral face of the penis instead of the end point of the glans penis. Although its prevalence varies according to geographical distribution, it can be summarised as 5.2-69/10,000 live births (Springer et al., 2016). The pathology is not only an abnormal location of the meatus, but various degrees of penile ventral curvature, inadequate development of the distal urethral segment and the ventral part of the prepuce also accompany to this situation (Chukwubuike et al., 2019). Although it has been frequently seen and researched for many years, pathophysiology has not been clearly elucidated. It is widely believed that environmental and genetic factors are effective in the aetiology of isolated hypospadias. Especially during the intrauterine

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