Topical Delivery of Erythromycin Through Cubosomes for Acne

Khan, S. Sudheer; Jain, Poorva; Jain, Sourabh; Jain, Richa; Bhargava, Satish; Jain, Aakanchha

doi:10.2174/2211738506666180209100222

Cited by 38 publications

(15 citation statements)

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“…This comes in accordance with Khan et al who reported an increase in E.E.% of Erythromycin with the increase of GMO concentration. 49 Meanwhile, an insignificant difference (p > 0.05) was detected between E.E.% of the cubosomes prepared using the weight ratio P407: GMO (1:5) to those prepared employing the ratio P407: GMO (1:7.5). This might be attributed to the complete saturation of the cubosomal layers by the drug.…”

Section: Determination Of Entrapment Efficiency and Drug Loading Capa...mentioning

confidence: 85%

Cubosomes as a Potential Oral Drug Delivery System for Enhancing the Hepatoprotective Effect of Coenzyme Q10

Mohsen

Younis

Salama

et al. 2021

Journal of Pharmaceutical Sciences

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Section: Determination Of Entrapment Efficiency and Drug Loading Capa...mentioning

confidence: 85%

Cubosomes as a Potential Oral Drug Delivery System for Enhancing the Hepatoprotective Effect of Coenzyme Q10

Mohsen

Younis

Salama

et al. 2021

Journal of Pharmaceutical Sciences

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“…Cubosomes Erythromycin Erythromycin-loaded cubosomes for the treatment of acne. [173] Hexosomes, cubosomes Ketoconazole Ketoconazole-loaded hexosomes for antifungal treatment. [174] Ufasomes Minoxidil Minoxidil-loaded ufasomes for the treatment of hair loss.…”

Section: Ethosomesmentioning

confidence: 99%

Lipid Nanoparticulate Drug Delivery Systems: Recent Advances in the Treatment of Skin Disorders

Stefanov

Andonova

2021

Pharmaceuticals

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The multifunctional role of the human skin is well known. It acts as a sensory and immune organ that protects the human body from harmful environmental impacts such as chemical, mechanical, and physical threats, reduces UV radiation effects, prevents moisture loss, and helps thermoregulation. In this regard, skin disorders related to skin integrity require adequate treatment. Lipid nanoparticles (LN) are recognized as promising drug delivery systems (DDS) in treating skin disorders. Solid lipid nanoparticles (SLN) together with nanostructured lipid carriers (NLC) exhibit excellent tolerability as these are produced from physiological and biodegradable lipids. Moreover, LN applied to the skin can improve stability, drug targeting, occlusion, penetration enhancement, and increased skin hydration compared with other drug nanocarriers. Furthermore, the features of LN can be enhanced by inclusion in suitable bases such as creams, ointments, gels (i.e., hydrogel, emulgel, bigel), lotions, etc. This review focuses on recent developments in lipid nanoparticle systems and their application to treating skin diseases. We point out and consider the reasons for their creation, pay attention to their advantages and disadvantages, list the main production techniques for obtaining them, and examine the place assigned to them in solving the problems caused by skin disorders.

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“…[ [59][60][61][62][63] LIPID NANOPARTICLES • Colloidal self-assembled dispersions with a hydrophobic matrix and a surfactant layer that facilitates dispersion in water. At body and room temperatures, lipid nanoparticles are solid.…”

Section: Cubosomesmentioning

confidence: 99%

Lipid Nanocarriers for Anti-HIV Therapeutics: a Focus on Physicochemical Properties and Biotechnological Advances

Faria¹,

Lopes²,

Neves³

et al. 2021

Preprint

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Since HIV was first identified, and in a relatively short period of time, AIDS has become one of the most devastating infectious diseases of the 21st century. Classical antiretroviral therapies were a major step forward in disease treatment options, significantly improving the survival rates of HIV-infected individuals. Even though these therapies have greatly improved HIV clinical outcomes, antiretrovirals (ARV) feature biopharmaceutic and pharmacokinetic problems such as poor aqueous solubility, short half-life and poor penetration into HIV reservoir sites, which contribute to the sub-optimal efficacy of these regimens. To overcome some of these issues, novel nanotechnology-based strategies for ARV delivery towards HIV viral reservoirs have been proposed. The current review focus on the benefits of using lipid-based nanocarriers for tuning the physicochemical properties of ARVs to overcome biological barriers upon administration. Furthermore, a correlation of these properties and the potential therapeutic outcomes has been established. Biotechnological advancements using lipid nanocarriers for RNA interference delivery for the treatment of HIV infections were also discussed.

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Topical Delivery of Erythromycin Through Cubosomes for Acne

Abstract: Thus, as a whole it can be concluded that erythromycin loaded cubosomes are effective in topically delivering drug in sustained and non-invasive manner for treatment and prevention of acne.

Cited by 38 publications

References 0 publications

Cubosomes as a Potential Oral Drug Delivery System for Enhancing the Hepatoprotective Effect of Coenzyme Q10

Cubosomes as a Potential Oral Drug Delivery System for Enhancing the Hepatoprotective Effect of Coenzyme Q10

Lipid Nanoparticulate Drug Delivery Systems: Recent Advances in the Treatment of Skin Disorders

Lipid Nanocarriers for Anti-HIV Therapeutics: a Focus on Physicochemical Properties and Biotechnological Advances

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