Topical Delivery of Ebselen Encapsulated in Biopolymeric Nanocapsules: Drug Repurposing Enhanced Antifungal Activity

Jaromin, Anna; Żarnowski, Robert; Pįętka-Ottlik, Magdalena; Andes, David R.; Gubernator, Jerzy

doi:10.2217/nnm-2017-0337

Cited by 39 publications

(11 citation statements)

References 50 publications

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“…Drug loaded nano-capsules are especially useful for skincare and dermatological treatments because of their enhanced bioavailability in dermal cells. Ebselen (Eb) is an example of a repurposed drug with poor aqueous solubility which requires a sophisticated delivery system such as nano-encapsulation for topical application as a promising, safe and complementary alternative to the treatment of cutaneous candidiasis (Jaromin et al, 2018). Examples of commercially available cosmeceutical products are "Hydra flash bronzer" a facial skin moisturizer, "Soleil soft-touch anti-wrinkle sunscreen, " "Soleil instant cooling sun" and "primordiale optimum lip" produced by Lancôme R .…”

Section: Nano-capsulesmentioning

confidence: 99%

Nanoscale Drug Delivery Systems: From Medicine to Agriculture

Vega-Vásquez

Mosier

Irudayaraj

2020

Front. Bioeng. Biotechnol.

197

107

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The main challenges in drug delivery systems are to protect, transport and release biologically active compounds at the right time in a safe and reproducible manner, usually at a specific target site. In the past, drug nano-carriers have contributed to the development of precision medicine and to a lesser extent have focused on its inroads in agriculture. The concept of engineered nano-carriers may be a promising route to address confounding challenges in agriculture that could perhaps lead to an increase in crop production while reducing the environmental impact associated with crop protection and food production. The main objective of this review is to contrast the advantages and disadvantages of different types of nanoparticles and nano-carriers currently used in the biomedical field along with their fabrication methods to discuss the potential use of these technologies at a larger scale in agriculture. Here we explain what is the problem that nano-delivery systems intent to solve as a technological platform and describe the benefits this technology has brought to medicine. Also here we highlight the potential drawbacks that this technology may face during its translation to agricultural applications, based on the lessons learned so far from its use for biomedical purposes. We discuss not only the characteristics of an ideal nano-delivery system, but also the potential constraints regarding the fabrication including technical, environmental, and legal aspects. A key motivation is to evaluate the potential use of these systems in agriculture, especially in the area of plant breeding, growth promotion, disease control, and post-harvest quality control. Further, we highlight the importance of a rational design of nano-carriers and identify current research gaps to enable scale-up relevant to applications in the treatment of plant diseases, controlled release of fertilizers, and plant breeding.

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Section: Nano-capsulesmentioning

confidence: 99%

Nanoscale Drug Delivery Systems: From Medicine to Agriculture

Vega-Vásquez

Mosier

Irudayaraj

2020

Front. Bioeng. Biotechnol.

197

107

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“…Caco-2 cells were grown in Dulbecco's modified Eagle's medium (DMEM) medium containing 20% FBS, 1% non-essential amino acids, GlutaMAX™ and antibiotics. Cell viability was determined as previously described [ 52 ] using the MTT assay [ 53 ]. Different doses of 2 , 3 , 6 , 12 dissolved in DMSO, CQ (in water) as well as unloaded and 3 -loaded (2.0 mg/ml) coarse o/w emulsions were added to each well, mixed and incubated for 24 or 48 h. Results were expressed as IC 50 values, or as the percentage of survival cells with respect to the control (not treated cells).…”

Section: Methodsmentioning

confidence: 99%

Azacarbazole n-3 and n-6 polyunsaturated fatty acids ethyl esters nanoemulsion with enhanced efficacy against Plasmodium falciparum

Jaromin

Parapini

Zaremba-Czogalla

et al. 2021

Bioactive Materials

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Alternative therapies are necessary for the treatment of malaria due to emerging drug resistance. However, many promising antimalarial compounds have poor water solubility and suffer from the lack of suitable delivery systems, which seriously limits their activity. To address this problem, we synthesized a series of azacarbazoles that were evaluated for antimalarial activity against D10 (chloroquine-sensitive) and W2 (chloroquine-resistant) strains of P. falciparum . The most active compound, 9 H -3-azacarbazole ( 3 ), was encapsulated in a novel o/w nanoemulsion consisting of ethyl esters of polyunsaturated fatty acids n-3 and n-6 obtained from flax oil as the oil phase, S mix (Tween 80 and Transcutol HP) and water. This formulation was further analyzed using transmission electron microscopy, dynamic light scattering and in vitro and in vivo studies. It was shown that droplets of the 3 -loaded nanosystem were spherical, with satisfactory stability, without cytotoxicity towards fibroblasts and intestinal cell lines at concentrations corresponding to twice the IC 50 for P. falciparum . Moreover, the nanoemulsion with this type of oil phase was internalized by Caco-2 cells. Additionally, pharmacokinetics demonstrated rapid absorption of compound 3 (t max = 5.0 min) after intragastric administration of 3 -encapsulated nanoemulsion at a dose of 0.02 mg/kg in mice, with penetration of compound 3 to deep compartments. The 3 -encapsulated nanoemulsion was found to be 2.8 and 4.2 times more effective in inhibiting the D10 and W2 strains of the parasite, respectively, compared to non-encapsulated 3 . Our findings support a role for novel o/w nanoemulsions as delivery vehicles for antimalarial drugs.

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“…Experiments were performed as described by Lewińska et al [ 1 ] and Jaromin et al [ 29 ]. Full-thickness pig skins were cleaned with tap water, separated from the underlying cartilage, then the subcutaneous fat was cut and stored at −20 °C for up to 1 month after preparation to ensure skin integrity.…”

Section: Methodsmentioning

confidence: 99%

Nanoemulsion Stabilized by Safe Surfactin from Bacillus subtilis as a Multifunctional, Custom-Designed Smart Delivery System

et al. 2020

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The developing field of bio-nanotechnology aims to advance colloidal research via the introduction of multifunctional nanoparticles to augment the dermal effectiveness of active substances. Self-emulsifying drug delivery systems (SEDDS)—isotropic mixtures of oils, surfactants, solvents and co-solvents or surfactants—are attracting interest in the cosmeceutical field. As part of this study, SEDDS systems containing vitamin C or vitamin E and curcumin were developed, whereby the bioavailability of the active compounds increased by enhancing their permeability to deeper layers of the skin. A composition consisting of 50% surfactin from Bacillus subtilis, 30% Transcutol and 20% oil phase was designed to encapsulate the active substances, i.e., vitamin C or vitamin E and curcumin, contained in the oil phase. The developed carriers were characterized by average particle sizes of 69–183 nm. The formulations with the vitamins were found to be physically and chemically stable for 6 months. Transdermal tests were carried out, showing that the carriers enable the transport of active substances deep into the skin, stopping at the dermis border. The formulations with vitamin C and vitamin E reduced the discoloration, the vascular lesions, and the depth of the wrinkles on the tested skin, which can be useful in cosmetics in the treatment of problem skin, including capillary and sensitive skin.

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Topical Delivery of Ebselen Encapsulated in Biopolymeric Nanocapsules: Drug Repurposing Enhanced Antifungal Activity

Cited by 39 publications

References 50 publications

Nanoscale Drug Delivery Systems: From Medicine to Agriculture

Nanoscale Drug Delivery Systems: From Medicine to Agriculture

Azacarbazole n-3 and n-6 polyunsaturated fatty acids ethyl esters nanoemulsion with enhanced efficacy against Plasmodium falciparum

Nanoemulsion Stabilized by Safe Surfactin from Bacillus subtilis as a Multifunctional, Custom-Designed Smart Delivery System

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