Topical creams of piperine loaded lipid nanocarriers for management of atopic dermatitis: development, characterization, and <i>in vivo</i> investigation using BALB/c mice model

Kumar, Puneet; Sharma, Dinesh Kumar; Ashawat, Mahendra Singh

doi:10.1080/08982104.2021.1880436

Cited by 14 publications

(11 citation statements)

References 41 publications

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“…From this perspective, one outstanding study was developed attempting the topical administration of piperine by including it in ETOs, thus overcoming the solubility and delivery issues, while exploring it as a therapeutic agent for AD [ 32 ]. ETOs are phospholipid-based flexible and elastic vesicles bearing an ethanolic core (20–45% ethanol), but also containing other key ingredients such as phosphatidylcholine, cholesterol, and water.…”

Section: Isolated Natural Compounds Included In Nanotechnology-based ...mentioning

confidence: 99%

“…ETOs are phospholipid-based flexible and elastic vesicles bearing an ethanolic core (20–45% ethanol), but also containing other key ingredients such as phosphatidylcholine, cholesterol, and water. Given the high content of ethanol in these nanocarriers, they have the capacity to easily penetrate the epidermic stratum corneum , thus promoting a deep and localized drug delivery into the skin [ 7 , 10 , 32 , 65 ]. According to the study of Kumar et al [ 32 ], piperine-loaded ETOs were prepared by the cold method, and for optimized ethosomal dispersion, the nanocarriers presented an EE of 74.30 ± 3.88% and a vesicle size of 318.1 nm.…”

Section: Isolated Natural Compounds Included In Nanotechnology-based ...mentioning

confidence: 99%

“…Given the high content of ethanol in these nanocarriers, they have the capacity to easily penetrate the epidermic stratum corneum , thus promoting a deep and localized drug delivery into the skin [ 7 , 10 , 32 , 65 ]. According to the study of Kumar et al [ 32 ], piperine-loaded ETOs were prepared by the cold method, and for optimized ethosomal dispersion, the nanocarriers presented an EE of 74.30 ± 3.88% and a vesicle size of 318.1 nm. In addition, the ZP of the formulated vesicles was 32.6 mV, and they were spherical in shape.…”

Section: Isolated Natural Compounds Included In Nanotechnology-based ...mentioning

confidence: 99%

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Nanotechnology-Based Topical Delivery of Natural Products for the Management of Atopic Dermatitis

et al. 2023

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Atopic dermatitis (AD) is a chronic eczematous inflammatory disease that may arise from environmental, genetic, and immunological factors. Despite the efficacy of current treatment options such as corticosteroids, such approaches are mainly focused on symptom relief and may present certain undesirable side effects. In recent years, isolated natural compounds, oils, mixtures, and/or extracts have gained scientific attention because of their high efficiency and moderate to low toxicity. Despite their promising therapeutic effects, the applicability of such natural healthcare solutions is somewhat limited by their instability, poor solubility, and low bioavailability. Therefore, novel nanoformulation-based systems have been designed to overcome these limitations, thus enhancing the therapeutic potential, by promoting the capacity of these natural drugs to properly exert their action in AD-like skin lesions. To the best of our knowledge, this is the first literature review that has focused on summarizing recent nanoformulation-based solutions loaded with natural ingredients, specifically for the management of AD. We suggest that future studies should focus on robust clinical trials that may confirm the safety and effectiveness of such natural-based nanosystems, thus paving the way for more reliable AD treatments.

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Section: Isolated Natural Compounds Included In Nanotechnology-based ...mentioning

confidence: 99%

Section: Isolated Natural Compounds Included In Nanotechnology-based ...mentioning

confidence: 99%

Section: Isolated Natural Compounds Included In Nanotechnology-based ...mentioning

confidence: 99%

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Nanotechnology-Based Topical Delivery of Natural Products for the Management of Atopic Dermatitis

et al. 2023

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“…The ethosome-based cream exhibited enhanced deposition in the epidermis and dermis. In an in vivo efficacy study using a BALB/c mice model, the ethosomal cream showed significant reductions in ear and skin thickness, skin severity, and levels of white blood cells, granulocytes, and IgE antibodies [ 118 ].…”

Section: Nanotechnological Approaches: For Effective Treatment Of Ato...mentioning

confidence: 99%

Challenges of current treatment and exploring the future prospects of nanoformulations for treatment of atopic dermatitis

Kakkar,

Saini,

Singh

2023

Pharmacol. Rep

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Atopic dermatitis (AD) is a predominant and deteriorating chronic inflammation of the skin, categorized by a burning sensation and eczematous lesions in diverse portions of the body. The treatment of AD is exclusively focused to limit the itching, reduce inflammation, and repair the breached barrier of the skin. Several therapeutic agents for the treatment and management of AD have been reported and are in use in clinics. However, the topical treatment of AD has been an unswerving challenge for the medical fraternity owing to the impaired skin barrier function in this chronic skin condition. To surmount the problems of conventional drug delivery systems, numerous nanotechnology-based formulations are emerging as alternative new modalities for AD. Latter enhances the bioavailability and delivery to the target disease site, improves drug permeation and therapeutic efficacy with reduced systemic and off-target side effects, and thus improves patient health and promotes compliance. This review aims to describe the various pathophysiological events involved in the occurrence of AD, current challenges in treatment, evidence of molecular markers of AD and its management, combinatorial treatment options, and the intervention of nanotechnology-based formulations for AD therapeutics. Graphical abstract

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“…As previously described, enhanced skin penetration is a crucial advantage of using nanocarriers to deliver therapeutics for AD therapy. Kumar and colleagues evaluated the efficacy of piperine-loaded ethosomal creams in treating AD compared to conventional creams 117 . The results showed that ethosomal creams displayed higher deposition in the epidermis and dermis and significantly reduced ear and skin thickness, skin severity, white blood cell (WBC), and granulocyte and IgE antibody levels in a mouse model, showing favorable potential for the treatment of AD.…”

Section: The Applications Of Nanocarrier- or Mn-based Transdermal Del...mentioning

confidence: 99%

Advanced nanocarrier- and microneedle-based transdermal drug delivery strategies for skin diseases treatment

Qu¹,

Geng²,

Liu³

et al. 2022

Theranostics

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Skin diseases are the fourth leading cause of nonfatal and chronic skin diseases, acting as a global burden and affecting the world economy. Skin diseases severely impact the patients' quality of life and have influenced their physical and mental state. Treatment of these skin disorders with conventional methods shows a lack of therapeutic efficacy, long treatment duration, recurrence of the condition, and systemic side effects due to improper drug delivery. However, these pitfalls can be overcome with the applications of advanced nanocarrier- and microneedle (MN)-based transdermal drug delivery strategies that provide efficient site-specific drug delivery at the target site. These advanced transdermal drug delivery strategies can be more effective than other drug administration routes by avoiding first-pass metabolism, enhancing the drug concentration in local skin lesions, and reducing systemic toxicity. Compared with traditional transdermal delivery methods, nanocarrier- or MN-based drug delivery systems are painless, noninvasive, or minimum-invasive and require no expensive equipment. More importantly, they can introduce more advanced functions, including increased skin penetration efficiency, controlled drug release rates, enhanced targeting abilities, and theranostic functions. Here, the emergence of versatile advanced transdermal drug delivery systems for the transdermal delivery of various drugs is reviewed, focusing on the design principles, advantages, and considerations of nanocarrier- and MN-based transdermal drug delivery strategies and their applications in treating diverse skin diseases, including psoriasis, dermatitis, melanoma, and other skin diseases. Moreover, the prospects and challenges of advanced transdermal delivery strategies for treating dermatological disorders are summarized.

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Topical creams of piperine loaded lipid nanocarriers for management of atopic dermatitis: development, characterization, and in vivo investigation using BALB/c mice model

Cited by 14 publications

References 41 publications

Nanotechnology-Based Topical Delivery of Natural Products for the Management of Atopic Dermatitis

Nanotechnology-Based Topical Delivery of Natural Products for the Management of Atopic Dermatitis

Challenges of current treatment and exploring the future prospects of nanoformulations for treatment of atopic dermatitis

Advanced nanocarrier- and microneedle-based transdermal drug delivery strategies for skin diseases treatment

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