Nanotechnology-Based Topical Delivery of Natural Products for the Management of Atopic Dermatitis

Abstract

Atopic dermatitis (AD) is a chronic eczematous inflammatory disease that may arise from environmental, genetic, and immunological factors. Despite the efficacy of current treatment options such as corticosteroids, such approaches are mainly focused on symptom relief and may present certain undesirable side effects. In recent years, isolated natural compounds, oils, mixtures, and/or extracts have gained scientific attention because of their high efficiency and moderate to low toxicity. Despite their promising therapeutic effects, the applicability of such natural healthcare solutions is somewhat limited by their instability, poor solubility, and low bioavailability. Therefore, novel nanoformulation-based systems have been designed to overcome these limitations, thus enhancing the therapeutic potential, by promoting the capacity of these natural drugs to properly exert their action in AD-like skin lesions. To the best of our knowledge, this is the first literature review that has focused on summarizing recent nanoformulation-based solutions loaded with natural ingredients, specifically for the management of AD. We suggest that future studies should focus on robust clinical trials that may confirm the safety and effectiveness of such natural-based nanosystems, thus paving the way for more reliable AD treatments.

A Research on the Electrical Conductivity of Hypereutectic Al-Si Compacts and B4C added Composites Produced by Conventional, Microwave and Spark Plasma Sintering Techniques

“…On the other hand, Chen-yu et al used glyceryl monostearate, stearic acid, and medium-chain triglycerides to prepare NLC for topical administration in rats with ear edema. The results showed a suppression of edema in the animals [126]. Speaking a bit about cancer, in a study by Sun et al, it was possible to induce apoptosis of MCF-7 and MDA-MB-231 breast cancer cells using NLC composed of 2.7% quercetin, 9.4% soy lecithin, 23.6% Glycerol 1,3-dido-decanoate 2-decanoate, 6.7% glyceryl tripalmi-tate, 13.4% vitamin E acetate and 44.2% Kolliphor® HS 15 [127].…”

Quercetin, a Flavonoid with Great Pharmacological Capacity

“…On the other hand, Chen-yu et al used glyceryl monostearate, stearic acid, and medium-chain triglycerides to prepare NLCs for topical administration in rats with ear edema. The results showed a suppression of edema in the animals [ 126 ]. Speaking a bit about cancer, in a study by Sun et al, it was possible to induce apoptosis of MCF-7 and MDA-MB-231 breast cancer cells using NLCs composed of 2.7% quercetin, 9.4% soy lecithin, 23.6% glycerol 1,3-dido-decanoate 2-decanoate, 6.7% glyceryl tripalmitate, 13.4% vitamin E acetate, and 44.2% Kolliphor ® HS 15 [ 127 ].…”

Skin Protection by Carotenoid Pigments

“…To facilitate bioavailability and protect the structure against enzymatic decomposition and physicochemical degradation, carotenoids are transformed into so-called nanotechnology products, or "controlled release systems", i.e., liposomes, micelles, lipid nanoparticles, polymer micro-, and nano-particles or nanocapsules [296][297][298][299][300][301]. Thanks to appropriate nanoencapsulation, nanosystems are protected against degradation and ensure active substance release control [202,295,[302][303][304][305]. Despite these undeniable advantages, some reservations are raised by the tendency of nanoparticles to agglomerate, potential toxicity, possibility of bioaccumulation, and production costs [306].…”