Topical capsaicin therapy in humans with hemodialysis-related pruritus

Weißhaar, Elke; Dunker, Nadine; Gollnick, Harald

doi:10.1016/s0304-3940(03)00511-1

Cited by 52 publications

(37 citation statements)

References 15 publications

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“…16,28 Additionally, as uremia progresses, peripheral nervous system becomes more affected, especially the sensory parts. 21 On the other hand, reports showing the efficacy of lidocaine, 29 capsaicin, [30][31][32] and gabapentin 33,34 in controlling UP are in favor of a relationship between neuropathy and pruritus in HD patients. Thus, we can only hypothesize that even in nondiabetic patients, disturbed glucose metabolism as demonstrated by higher HbA1c levels, at least by inducing permissive role for the development of neuropathy, may result in increased sensation of itching.…”

Section: Discussionmentioning

confidence: 99%

HbA1c Is Related with Uremic Pruritus in Diabetic and Nondiabetic Hemodialysis Patients

Afsar

Afşar

2011

Renal Failure

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Objective: Uremic pruritus (UP) remains a frequent problem in hemodialysis (HD) patients and is related to mortality. Poor glycemic control, as evaluated by hemoglobin A1c (HbA1c), is also associated with morbidity and mortality in HD patients. In this study, we investigated the relationship between UP and HbA1c in HD patients. Methods: Sociodemographic, clinical, and laboratory variables, depressive symptoms, and health-related quality of life were assessed. Severity of UP was evaluated by visual analogue scale (VAS). The scale consisted of a 10 cm horizontal line marked from 0 (denoting no itch) to 10 (denoting worst possible imaginable itch). Results: Totally, 75 patients (male/female, 41/34; diabetic/nondiabetic, 29/46; age, 51.9 ± 13.5 years) were included. The VAS pruritus score was higher in diabetic patients compared with nondiabetic patients (4.7 ± 2.8 vs. 3.0 ± 1.0, p : 0.015). In diabetics, VAS pruritus score was independently related with calcium-phosphorus product (b : +0.637, p < 0

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Section: Discussionmentioning

confidence: 99%

HbA1c Is Related with Uremic Pruritus in Diabetic and Nondiabetic Hemodialysis Patients

Afsar

Afşar

2011

Renal Failure

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“…Neonatal capsaicin treatment almost completely abolishes spontaneous scratching in mice with chronic dermatitis ( 17). Repeated topical application of capsaicin reduces itch of several pruritic diseases, including psoriasis (20., 21 ), prurigo nodularis (22), notalgia paraesthetica (23), aquagenic pruritus (24) and renal failure (25)(26)(27). Repeated application of capsaicin does not suppress histamine-induced itching in patients with atopic eczema, although it inhibits it in heahhy subjects (14).…”

Section: Discussionmentioning

confidence: 99%

Different Roles of Capsaicin-sensitive and H1 Histamine Receptor-expressing Sensory Neurones in Itch of Mosquito Allergy in Mice

Nakano

Andoh²,

Sasaki³

et al. 2008

Acta Derm Venerol

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Although mosquito allergy induces the release of histamine, the itch-related response, scratching, is not effectively suppressed by blockade of H1 histamine receptors. To address this question, we examined the effects of neonatal capsaicin treatment on allergic reactions and H1 histamine receptor-expressing sensory neurones in mice. Neonatal capsaicin treatment almost completely abolished allergy-associated scratching, without effects on plasma extravasation or increase in serum concentrations of immunoglobulins E and G1. An injection of edema contents from an animal exhibiting allergic reaction elicited scratching in naive animals, suggesting the production of pruritogen(s) by allergic reaction; this production was not suppressed by neonatal capsaicin treatment. This treatment markedly decreased the number of sensory neurones immunoreactive for TRPV1 capsaicin receptor, with little effect on sensory neurones immunoreactive for neurofilament 200, a marker of myelinated A-fibre neurones. In addition, there was a trend towards a reduction in numbers of sensory neurones immunoreactive for H1 histamine receptor. The results suggest that capsaicin-sensitive sensory neurones that lack H1 histamine receptors play a key role in signalling of allergic itch.

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“…In another study, Weisshaar et al [41] reported that 11 pruritic patients on HD and 10 controls were treated with capsaicin 0.05% liniment on the upper back three times daily for 5 days. Study parameters investigated were wheal and flare reactions, itch, and alloknesis (perifocal itch sensation induced by usually non-itching stimuli) after serotonin and histamine iontophoresis in treated and untreated skin.…”

Section: Topical Treatmentsmentioning

confidence: 99%

Recent Advances in Treatment for Uremic Pruritus

Suzuki¹,

Omata²,

Kumagai³

2015

OJNeph

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This review highlights recent advances in pathophysiology and treatment for uremic pruritus, especially focusing on various interventions. Pruritus in patients on hemodialysis (HD) and peritoneal dialysis (PD) still remains an unresolved issue. Recently, the efficacy and safety of nalfurafine hydrochloride have been reported in Japan, and at present, more than thirty thousand patients receive this new drug. In comparison with the efficacy of this new drug, acupuncture, a form of traditional Japanese therapy, has been validated for relief of symptoms of pruritus. In this review, various interventions for relief of symptoms of pruritus as well as recent studies on its pathophysiology will be introduced. This review will be helpful for treatment of pruritus in patients on dialyzed therapy in clinical practice.

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Topical capsaicin therapy in humans with hemodialysis-related pruritus

Cited by 52 publications

References 15 publications

HbA1c Is Related with Uremic Pruritus in Diabetic and Nondiabetic Hemodialysis Patients

HbA1c Is Related with Uremic Pruritus in Diabetic and Nondiabetic Hemodialysis Patients

Different Roles of Capsaicin-sensitive and H1 Histamine Receptor-expressing Sensory Neurones in Itch of Mosquito Allergy in Mice

Recent Advances in Treatment for Uremic Pruritus

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