Topical capsaicin for chronic neuropathic pain in adults

Derry, Sheena; Moore, R Andrew; McQuay, Henry J; Lloyd, Rosalind

doi:10.1002/14651858.cd007393

Cited by 24 publications

(25 citation statements)

References 25 publications

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“…However, even in this arena, evidence for the effectiveness or safety of capsaicin use in pain relief is controversial. Application of capsaicin to the skin causes an enhanced sensitivity to noxious stimuli, followed by a period with reduced sensitivity and, after repeated applications, persistent desensitization (37). Capsaicin-induced dermal pain is common after exposure to capsaicin-containing hot peppers, personal protection sprays, or topical creams (38).…”

Section: The Paradox Of Topical Application Of Capsaicinmentioning

confidence: 99%

The Two Faces of Capsaicin

2011

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Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is the principal pungent component in hot peppers, including red chili peppers, jalapeños, and habaneros. Consumed worldwide, capsaicin has a long and convoluted history of controversy about whether its consumption or topical application is entirely safe. Conflicting epidemiologic data and basic research study results suggest that capsaicin can act as a carcinogen or as a cancer preventive agent. Capsaicin is unique among naturally occurring irritant compounds because the initial neuronal excitation evoked is followed by a long-lasting refractory period, during which the previously excited neurons are no longer responsive to a broad range of stimuli. This process is referred to as desensitization and has been exploited for its therapeutic potential. Capsaicin-containing creams have been in clinical use for many years to relieve a variety of painful conditions. However, their effectiveness in pain relief is also highly debated and some adverse side effects have been reported. We have found that chronic, long-term topical application of capsaicin increased skin carcinogenesis in mice treated with a tumor promoter. These results might imply that caution should be exercised when using capsaicin-containing topical applications in the presence of a tumor promoter, such as, for example, sunlight. Cancer Res; 71(8);

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Section: The Paradox Of Topical Application Of Capsaicinmentioning

confidence: 99%

The Two Faces of Capsaicin

2011

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“…Capsaisin is already commercially available as dermal formulation in pain relief and local inflammatory diseases (e.g. Stilene s , RadoSalil s ) and is being investigated in several clinical trials for several indications which have been reviewed manifold (Bode and Dong, 2011;Derry et al, 2009;Qureshi et al, 2008;ReyesEscogido et al, 2011;Wallace and Pappagallo, 2011). Various Echinacea formulations (e.g.…”

Section: Othersmentioning

confidence: 99%

Alkamid database: Chemistry, occurrence and functionality of plant N-alkylamides

Boonen

Bronselaer

Nielandt

et al. 2012

Journal of Ethnopharmacology

130

109

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a b s t r a c tEthnopharmacological relevance: N-Alkylamides (NAAs) are a promising group of bioactive compounds, which are anticipated to act as important lead compounds for plant protection and biocidal products, functional food, cosmeceuticals and drugs in the next decennia. These molecules, currently found in more than 25 plant families and with a wide structural diversity, exert a variety of biologicalpharmacological effects and are of high ethnopharmacological importance. However, information is scattered in literature, with different, often unstandardized, pharmacological methodologies being used. Therefore, a comprehensive NAA database (acronym: Alkamid) was constructed to collect the available structural and functional NAA data, linked to their occurrence in plants (family, tribe, species, genus). Materials and methods: For loading information in the database, literature data was gathered over the period 1950-2010, by using several search engines. In order to represent the collected information about NAAs, the plants in which they occur and the functionalities for which they have been examined, a relational database is constructed and implemented on a MySQL back-end. Results: The database is supported by describing the NAA plant-, functional-and chemical-space. The chemical space includes a NAA classification, according to their fatty acid and amine structures. Conclusions: The Alkamid database (publicly available on the website http://alkamid.ugent.be/) is not only a central information point, but can also function as a useful tool to prioritize the NAA Q8 choice in the evaluation of their functionality, to perform data mining leading to quantitative structure-property relationships (QSPRs), functionality comparisons, clustering, plant biochemistry and taxonomic evaluations.

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“…Application of capsaicin to the skin causes an enhanced sensitivity to noxious stimuli, followed by a period with reduced sensitivity and, after repeated applications, persistent desensitization 48 .…”

Section: Toxicological Aspects Of Capsaicinmentioning

confidence: 99%

Untitled

2016

IJPSR

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ABSTRACT:The northeast region of India, considered as "hot spot" of biodiversity, having unique ecological environment with hot and high-humidity conditions, has given rise to the world"s hottest chilli, "Bhut jolokia or Bih jolokia", which is at least two times hotter than Red Savina Habanero in terms of Scoville heat units (SHU). The Assamese word "bhut" refers to the typical large pod size of the plant, while the term "bih" means "poison" indicating the high hotness in the fruits of the plant. It is extensively grown in North Eastern region of India, predominantly in the states of Assam, Nagaland, Manipur and Mizoram since ancient time. The main pungency principle of Bhut jolokia (Capsicum chinense Jacq.) is capsaicin (8-methyl-N-vanillyl-6-nonenamide) and its analogs collectively known as capsaicinoids synthesized in the epidermal cells of placenta of the fruit, and possesses anti-inflammatory and antioxidant activities. This review gives an update mainly on the pharmacological activities of Bhut jolokia (Capsicum Chinense Jaqc.), benefits and toxicity of capsaicin.

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Topical capsaicin for chronic neuropathic pain in adults

Cited by 24 publications

References 25 publications

The Two Faces of Capsaicin

The Two Faces of Capsaicin

Alkamid database: Chemistry, occurrence and functionality of plant N-alkylamides

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