The Two Faces of Capsaicin

Bode, Ann M.; Dong, Zigang

doi:10.1158/0008-5472.can-10-3756

Cited by 241 publications

(176 citation statements)

References 42 publications

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“…Capsaisin is already commercially available as dermal formulation in pain relief and local inflammatory diseases (e.g. Stilene s , RadoSalil s ) and is being investigated in several clinical trials for several indications which have been reviewed manifold (Bode and Dong, 2011;Derry et al, 2009;Qureshi et al, 2008;ReyesEscogido et al, 2011;Wallace and Pappagallo, 2011). Various Echinacea formulations (e.g.…”

Section: Othersmentioning

confidence: 99%

“…spilanthol (1) (Rios et al, 2007), by interfering with voltage-gated sodium channels or via desensitization of the TRPV1 receptor. TRPV1 agonists initially stimulate sensory neurons and release of substance P, followed by a long-lasting refractory period, during which the previously excited neurons are no longer responsive to a broad range of stimuli (Bode and Dong, 2011;Luo et al, 2011;Pal et al, 2009). Therefore, prolonged ingestion or topical application of capsaicinoids can be successful in managing painful conditions such as rheumatoid arthritis, osteoarthritis, diabetic neuropathy, postherpetic, neuralgia, postmastectomy pain syndrome, cluster headache, reflex sympathetic dystrophy and gastro-intestinal related problems like reflux and functional dyspepsia (Holzer, 2011;Philip and Thakur, 2011).…”

Section: Othersmentioning

confidence: 99%

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Alkamid database: Chemistry, occurrence and functionality of plant N-alkylamides

Boonen

Bronselaer

Nielandt

et al. 2012

Journal of Ethnopharmacology

129

109

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a b s t r a c tEthnopharmacological relevance: N-Alkylamides (NAAs) are a promising group of bioactive compounds, which are anticipated to act as important lead compounds for plant protection and biocidal products, functional food, cosmeceuticals and drugs in the next decennia. These molecules, currently found in more than 25 plant families and with a wide structural diversity, exert a variety of biologicalpharmacological effects and are of high ethnopharmacological importance. However, information is scattered in literature, with different, often unstandardized, pharmacological methodologies being used. Therefore, a comprehensive NAA database (acronym: Alkamid) was constructed to collect the available structural and functional NAA data, linked to their occurrence in plants (family, tribe, species, genus). Materials and methods: For loading information in the database, literature data was gathered over the period 1950-2010, by using several search engines. In order to represent the collected information about NAAs, the plants in which they occur and the functionalities for which they have been examined, a relational database is constructed and implemented on a MySQL back-end. Results: The database is supported by describing the NAA plant-, functional-and chemical-space. The chemical space includes a NAA classification, according to their fatty acid and amine structures. Conclusions: The Alkamid database (publicly available on the website http://alkamid.ugent.be/) is not only a central information point, but can also function as a useful tool to prioritize the NAA Q8 choice in the evaluation of their functionality, to perform data mining leading to quantitative structure-property relationships (QSPRs), functionality comparisons, clustering, plant biochemistry and taxonomic evaluations.

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Section: Othersmentioning

confidence: 99%

Section: Othersmentioning

confidence: 99%

Alkamid database: Chemistry, occurrence and functionality of plant N-alkylamides

Boonen

Bronselaer

Nielandt

et al. 2012

Journal of Ethnopharmacology

129

109

View full text Add to dashboard Cite

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“…5 Capsaicin is also used to induce cell-cycle arrest or apoptosis or inhibit cell proliferation in a variety of cancer cells. 6 Some capsaicin containing creams are used for the treatment of painful conditions such as long-term neuropathic pain in cancer patients 7 and diabetic neuropathy. 8 The quantity of active compounds depends on several factors such as intra species variability, environmental conditions, geographical variations, harvesting and storage time and extraction methods.…”

Section: Introductionmentioning

confidence: 99%

Validation of Capsaicin in Indian Capsicum Species Through RP-HPLC

Nag¹,

Chanda²,

Biswas³

et al. 2017

IJPER

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Capsaicin is a pungent capsacinoid which differs in capsicum fruit within the species and the cultivars due to its topographical diversity. Here, a comparative estimation of capsaicin in seven varieties of capsicum has been performed by RP-HPLC method. The method was carried out in reverse phase C 18 column using acetonitrile and water (1% acetic acid) as mobile phase (65:35 v/v), at the flow rate of 1ml/min. The λmax was detected at 230 nm. The calibration curves were linear in the concentration range of 1-80 µg/ml. The comparative study revealed that the capsaicin content was highest (3.12% w/w) in Capsicum annuum Cayenne whereas Capsicum cardenasii contains the lowest (0.85% w/w). The % RSD of precision and recovery was found to be < 2%, which confirms high repeatability of the method. This method can be commercialized at industrial level for ensuring the highest quality of capsicum used as raw material.

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“…Consumed worldwide, capsaicin has a long and convoluted history of controversy about whether its consumption or topical application is entirely safe. Conflicting epidemiologic data and basic research study results suggest that capsaicin can act as a carcinogen or as a cancer preventive agent (Bode, 2011). There are few studies reporting on the role of chilli eating and risk of cancer.…”

Section: Discussionmentioning

confidence: 99%