Lifestyle Factors Including Diet and Leukemia Development: a Case-Control Study from Mumbai, India

Ganesh, B; Saoba, Sushama; Sarhade, Monika Nilesh; Kolekar, Suvarna Anand

doi:10.7314/apjcp.2013.14.10.5657

Cited by 15 publications

(10 citation statements)

References 21 publications

(22 reference statements)

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“…High exposure to pesticides and other agricultural related products have been implicated in some studies (Rajabli et al, 2013;Zheng et al, 2013), but not others (Balasubramaniam et al, 2013). Tobacco appears to be a risk factor (Balasubramaniam et al, 2013). and null genotypes of both GSTM1 and GSTT1 genes may confer elevated risk of chronic myeloid leukaemia (Bhat et al, 2012), implying carcinogen involvement.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Assessment of Leukemia in Kazakhstan, 2003-2012

Igissinov

Kulmirzayeva²,

Moore³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Cancer is a major health problem facing the entire world, and Kazakhstan is not the exception. The aim of this study was to present an epidemiological assessment of leukemia in the population of Kazakhstan during 2003-2012. This descriptive and retrospective study was based on data obtained from all oncological organizations of the whole country. Age standardized incidence rates per 100,000 population for leukemia were calculated. Totally, 6,741 new cases of leukemia were registered in Kazakhstan during the 10 year period. The mean age of patients with leukemia was 48.5. The ASRs for leukemia among men and women were 5.3 and 3.6, respectively (p<0.001). In conclusion, our results showed a high incidence rate of leukemia in Kazakhstan, especially in the north of the country. The incidence of leukemia was significantly higher in males and increased with age. Determining and controlling important risk factors of leukemia may lead to decrease in its burden.

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Section: Discussionmentioning

confidence: 99%

Epidemiological Assessment of Leukemia in Kazakhstan, 2003-2012

Igissinov

Kulmirzayeva²,

Moore³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Only 0.11% (0.05%-0.26%) of inhaled benzene is metabolized to SPMA, which has a short half-life; mean ranges from 9 to 13 hours (39)(40)(41). Cigarette smoking is regarded as a source of benzene intake and an established risk factor for adult acute myelogenous leukemia (42)(43)(44)(45)(46)(47)(48)(49). Cigarette smokers have elevated excretion of SPMA, as much as ten times higher than non-smokers (50).…”

Section: Introductionmentioning

confidence: 99%

Benzene Uptake in Hookah Smokers and Non-smokers Attending Hookah Social Events: Regulatory Implications

Kassem

Jackson

Liles

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Benzene is a human hematotoxicant and a leukemogen that causes lymphohematopoietic cancers, especially acute myelogenous leukemia. We investigated uptake of benzene in hookah smokers and non-smokers attending hookah social events in naturalistic settings where hookah tobacco was smoked exclusively.Methods: We quantified S-phenylmercapturic acid (SPMA), a metabolite of benzene, in the urine of 105 hookah smokers and 103 non-smokers. Participants provided spot urine samples the morning of and the morning after attending an indoor hookah-only smoking social event at a hookah lounge or in a private home.Results: Urinary SPMA levels in hookah smokers increased significantly following a hookah social event (P < 0.001). This increase was 4.2 times higher after hookah lounge events (P < 0.001) and 1.9 times higher after home events (P ¼ 0.003). In non-smokers, urinary SPMA levels increased 2.6 times after hookah lounge events (P ¼ 0.055); however, similar urinary SPMA levels were detected before and after home events, possibly indicating chronic exposure to benzene (P ¼ 0.933).Conclusions: Our data provide the first evidence for uptake of benzene in hookah smokers and non-smokers exposed to hookah tobacco secondhand smoke at social events in private homes compared with their counterparts in hookah lounges. Hookah tobacco smoke is a source of benzene exposure, a risk factor for leukemia.Impact: Because there is no safe level of exposure to benzene, our results call for interventions to reduce or prevent hookah tobacco use, regulatory actions to limit hookah-related exposure to toxicants including benzene, initiate labeling of hookah-related products, and include hookah smoking in clean indoor air legislation. Cancer Epidemiol Biomarkers Prev; 23(12); 2793-809. Ó2014 AACR.

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“…However, a cohort study from the same country showed a 50% increased risk of AML for current smokers[ 29 ]; this study also indicated no association between current and former smokers with CML, ALL, CLL or MM. An Indian case-control study reported an increase of 2.1 fold in the risk of leukemia in the cigarette smokers, compared to non-smokers[ 30 ]. A US cohort study that evaluated risk factors for AML, showed hazard ratios of 1.79, 2.42 and 2.29 for former smokers of > 1 pack/d, current smokers of ≤ 1 pack/d, and current smokers of > 1 pack/d, respectively[ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Cigarette smoking, dietary habits and genetic polymorphisms inGSTT1,GSTM1andCYP1A1metabolic genes: A case-control study in oncohematological diseases

Cerliani¹,

Pavicic²,

Gili³

et al. 2016

WJCO

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AIMTo analyze the association between oncohematological diseases and GSTT1/GSTM1/CYP1A1 polymorphisms, dietary habits and smoking, in an argentine hospital-based case-control study.METHODSThis hospital-based case-control study involved 125 patients with oncohematological diseases and 310 control subjects. A questionnaire was used to obtain sociodemographic data and information about habits. Blood samples were collected, and DNA was extracted using salting out methods. Deletions in GSTT1 and GSTM1 (null genotypes) were addressed by PCR. CYP1A1 MspI polymorphism was detected by PCR-RFLP. Odds ratio (OR) and 95%CI were calculated to estimate the association between each variable studied and oncohematological disease.RESULTSWomen showed lower risk of disease compared to men (OR 0.52, 95%CI: 0.34-0.82, P = 0.003). Higher levels of education (> 12 years) were significantly associated with an increased risk, compared to complete primary school or less (OR 3.68, 95%CI: 1.82-7.40, P < 0.001 adjusted for age and sex). With respect to tobacco, none of the smoking categories showed association with oncohematological diseases. Regarding dietary habits, consumption of grilled/barbecued meat 3 or more times per month showed significant association with an increased risk of disease (OR 1.72, 95%CI: 1.08-2.75, P = 0.02). Daily consumption of coffee also was associated with an increased risk (OR 1.77, 95%CI: 1.03-3.03, P = 0.03). Results for GSTT1, GSTM1 and CYP1A1 polymorphisms showed no significant association with oncohematological diseases. When analyzing the interaction between polymorphisms and tobacco smoking or dietary habits, no statistically significant associations that modify disease risk were found.CONCLUSIONWe reported an increased risk of oncohematological diseases associated with meat and coffee intake. We did not find significant associations between genetic polymorphisms and blood cancer.

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Lifestyle Factors Including Diet and Leukemia Development: a Case-Control Study from Mumbai, India

Cited by 15 publications

References 21 publications

Epidemiological Assessment of Leukemia in Kazakhstan, 2003-2012

Epidemiological Assessment of Leukemia in Kazakhstan, 2003-2012

Benzene Uptake in Hookah Smokers and Non-smokers Attending Hookah Social Events: Regulatory Implications

Cigarette smoking, dietary habits and genetic polymorphisms inGSTT1,GSTM1andCYP1A1metabolic genes: A case-control study in oncohematological diseases

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