Epidemiological Assessment of Leukemia in Kazakhstan, 2003-2012

Igissinov, Nurbek; Kulmirzayeva, Dariyana; Moore, Malcolm A; Igissinov, Saginbek; Baidosova, Gulnara; Akpolatova, Gulnur; Bukeyeva, Zhanar; Omralina, Y

doi:10.7314/apjcp.2014.15.16.6969

Cited by 8 publications

(7 citation statements)

References 22 publications

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“…Mortality was the highest in an older age group (>70 years) in both men and women. This result is consistent with that of a study in the United States that reported a leukemia-related mortality rate of 2.9/100 000 versus 60/100 000 in men aged <65 versus ≥65 years, respectively, and 2.0/100 000 versus 32/100 000 in women aged <65 versus ≥65 years, respectively ( Igissinov et al, 2014 ). Compared with the mortality rate, which is usually higher in the elderly, the AYLL lends greater weight to age for diseases that result in younger deaths and less weight to age for diseases affecting the elderly ( Pham, Fujino, Matsuda, & Yoshimura, 2010 ).…”

Section: Discussionsupporting

confidence: 92%

Leukemia-Related Mortality in Inner Mongolia, 2008–2012

Hao¹,

Chen²,

Xu³

et al. 2015

GJHS

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In this study, we aimed to determine the leukemia-related mortality rates and associated sociodemographic characteristics in the Inner Mongolia region of China. We obtained data for the period 2008–2012 from the Death Registry System maintained by the Inner Mongolia Centers for Disease Control and Prevention. We computed the percentages of leukemia-related deaths and controls diagnosed by various methods and at different levels of hospitals. The χ2 test was used to examine differences in leukemia-related mortality according to sex. We also calculated potential years of life lost (PYLL) and average years of life lost. Unconditional logistic regression models were used to analyze the effect of sociodemographic characteristics. The sex-adjusted leukemia-related mortality rate was 3.74/100 000. The mortality rate in men (4.27/100 000) was significantly higher than that in women (3.17/100 000), as was the respective PYLL (8040.5 vs. 6000.5 person-years). Mortality increased with increasing age in both men and women. The highest mortality rate was observed in those over 70 years of age for both men (18.36/100 000) and women (7.68/100 000). Men with a higher education level showed an increased risk of leukemia (odds ratio [OR] = 1.45, 95% confidence interval [CI] = 1.02–2.07, P = 0.04). In men, unemployment was associated with leukemia-related death (OR = 0.63, 95% CI = 0.42–0.95, P = 0.03). The leukemia-related mortality rate in Inner Mongolia was higher than that worldwide and that in China. A higher level of education and unemployment were associated with leukemia-related mortality in Inner Mongolia.

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Section: Discussionsupporting

confidence: 92%

Leukemia-Related Mortality in Inner Mongolia, 2008–2012

Hao¹,

Chen²,

Xu³

et al. 2015

GJHS

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“…Similar studies in USA concerning blood cancer in Europe and USA in 2005 showed that overall incidences for hematopoietic malignancies have been raised along western countries and AML incidence had slow decrease or stable trend in the most European countries but it has been surged in Wales and England about 70% from 1971 for both sexes (Rodriguez-Abreu et al, 2007). Also researches have shown that different blood cancer incidence are higher among men (than women) which is comparable in the countries including Iran, Kazakhstan, Croatia, European union and United states (Coebergh et al, 2006;Tahmasebi et al, 2006;Rodriguez-Abreu et al, 2007;Hejazi et al, 2010;Sant et al, 2010;Dastgiri et al, 2011;Farahmand et al, 2011;Modak et al, 2011;Smith et al, 2011;Dores et al, 2012;Novak et al, 2012;Rajabli et al, 2013) and higher incidence among men may be attributed to genetically or environmental factors (Rajabli et al, 2013;Igissinov et al, 2014).…”

Section: Discussionmentioning

confidence: 91%

“…During a study which was done by Tahmasebi et al in Mazandaran province during 1996-2003, an increasing trend for 8 years period was observed, with non-Hutchkin lymphoma as the highest incidence rate and myeloma leukemia has the lowest incidence rate (Tahmasebi et al, 2006). Farahmand et al found during their study that standard incidence rate for blood cancer among children during a 8 years' time period i.e.…”

Section: Discussionmentioning

confidence: 99%

“…During a research which was done in Kazakhstan from 2003-2012, blood cancer incidence has been decreased from 4.3 to 3.2 (Igissinov et al, 2014) and one study in Hong Kong showed a stable trend for blood cancer from 1990-2008 (Xie et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Also an incidence increase has been observed in a twenty years period in Netherlands among women between 50-64 years old (Van den Broek et al, 2012) and for Denmark between 1943-2003(Thygesen et al, 2009.…”

Section: Introductionmentioning

confidence: 93%

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Leukemia in Iran: Epidemiology and Morphology Trends

Koohi

Salehiniya²,

Shamlou³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Leukemia accounts for 8% of total cancer cases and involves all age groups with different prevalence and incidence rates in Iran and the entire world and causes a significant death toll and heavy expenses for diagnosis and treatment processes. This study was done to evaluate epidemiology and morphology of blood Statistical analysis for incidence time trends and morphology change percentage was performed with joinpoint regression analysis using the software Joinpoint Regression Program. Results: During the studied years a total of 18,353 hematopoietic and reticuloendothelial system cancers were recorded. Chi square test showed significant difference between sex and morphological types of blood cancer (P-value<0.001). Joinpoint analysis showed a significant increasing trend for the adjusted standard incidence rate (ASIR) for both sexes (P-value<0.05). Annual percent changes (APC) for women and men were 18.7 and 19.9, respectively. The most common morphological blood cancers were ALL, ALM, MM and CLL which accounted for 60% of total hematopoietic system cancers. Joinpoint analyze showed a significant decreasing trend for ALM in both sexes (P-value<0.05). Conclusions: Hematopoietic system cancers in Iran demonstrate an increasing trend for incidence rate and decreasing trend for ALL, ALM and CLL morphology.

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Current State of Diagnosis and Treatment of Acute Myeloid Leukemias in Adult Patients in the Republic of Kazakhstan

Клодзинский¹,

Pivovarova²,

Turgunova

et al. 2022

Клиническая онкогематология

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Background. In recent years, the incidence of acute myeloid leukemias (AML) globally has continued to increase. Current approaches to AML treatment remain a challenge for the healthcare in many countries. There are only single studies on the analysis of AML state in adult patients in Kazakhstan. Over the last 10 years in Kazakhstan, no results of AML monitoring in adult patients have been available. Aim. To study the characteristics of clinical course and treatment outcomes in AML in the Central Kazakhstan and in the city of Ust-Kamenogorsk, East Kazakhstan Region. Materials & Methods. The study enrolled 86 AML patients (46 men and 40 women), the median age was 60.5 years (range 19-86 years); 64 (74.4 %) patients were from Karaganda Region, 15 (17.4 %) patients were from Ust-Kamenogorsk, and 7 (8.1 %) patients were from other regions of Kazakhstan. The analysis covered the structure and treatment outcomes in newly diagnosed AML patients within the period from 2018 to June, 2021. Statistical analysis of data was made using SPSS Statistics 23.0. Results. The analysis of diagnostic techniques showed that myelogram and immunophenotyping were used in 98.8 %, cytogenetic assay was made in 18 %, and molecular analysis was performed in 59.3 % of patients. The “7+3” remission induction was administered in 54.6 % of patients, 20.9 % of patients were treated with hypomethylating agents and low doses of cytarabine, and 24.4 % of patients were on palliative and supportive therapy. Out of 47 patients treated with the “7+3” remission induction, complete clinical hematological remission was reached in 29 (61.7 %) patients. Primary resistance was reported in 21.3 % of patients. Early mortality (death within 30 days from the start of induction) rate was 17 %. High-dose cytarabine consolidation (1.5-3 g/m<sup>2</sup> twice every other day, 2-3 courses) was administered to 75.8 % of patients. All the allogeneic bone marrow transplantations (n = 7) were performed at the National Research Center for Oncology and Transplantology in Nur-Sultan. The median overall survival in the group of standard “7+3” chemotherapy recipients was 11 months (range 1-83 months), and the median disease-free survival was 9 months (range 2-79 months). Conclusion. The study presents the characteristics and short-term outcomes of treatment of adult AML patients in Kazakhstan. The study limitations were a short follow-up period and enrollment of patients only from two regions of Kazakhstan. It is necessary to continue improving the current standards of AML diagnosis and treatment of adult patients.

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Epidemiological Assessment of Leukemia in Kazakhstan, 2003-2012

Cited by 8 publications

References 22 publications

Leukemia-Related Mortality in Inner Mongolia, 2008–2012

Leukemia-Related Mortality in Inner Mongolia, 2008–2012

Leukemia in Iran: Epidemiology and Morphology Trends

Current State of Diagnosis and Treatment of Acute Myeloid Leukemias in Adult Patients in the Republic of Kazakhstan

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