Topical applications of vitamin D on implant surface for bone‐to‐implant contact enhance: a pilot study in dogs part <scp>II</scp>

Salomó-Coll, Oscar; Val, José Eduardo Maté-Sánchez de; Ramírez-Fernández, María Piedad; Hernández–Alfaro, Federico; Gargallo‐Albiol, Jordi; Calvo-Guirado, José Luís

doi:10.1111/clr.12707

Cited by 34 publications

(46 citation statements)

References 46 publications

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“…117 Similar results were reported in mice with chronic kidney disease (CKD), suggesting that vitamin D treatment may be an effective approach for implant placement in patients with CKD. 124 Recently, the effect of topical application of vitamin D (10%) 125 and melatonin (5%) 126 solutions on the surface of immediate implants placed in dogs was evaluated. Both topical applications improved significantly new bone formation around implants and reduced crestal bone loss at 12 weeks following surgery, 126 standing out the positive correlation between vitamin D and early stages of osseointegration.…”

Section: Cholesterol and Fatty Acidsmentioning

confidence: 99%

Basis of bone metabolism around dental implants during osseointegration and peri‐implant bone loss

Ínsua

Monje

Wang

et al. 2017

J Biomedical Materials Res

188

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Despite the growing number of publications in the field of implant dentistry, there are limited studies to date investigating the biology and metabolism of bone healing around dental implants and their implications in peri-implant marginal bone loss. The aim of this review article is to provide a thorough understanding of the biological events taking place during osseointegration and the subsequent early and late phases of bone remodeling around dental implants. An update on the coupling mechanism occurring during bone resorption-bone remodeling is provided, focused on the relevance of the osteocytes, bone lining cells and immune cells during bone maintenance. An electronic and manual literature search was conducted by three independent reviewers in several databases, including MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Cochrane Oral Health Group Trials Register databases for articles up to September 2016 with no language restriction. Local bone metabolism is subject to signals from systemic calcium-phosphate homeostasis and bone remodeling. Three areas of interest were reviewed due to recent reported compromises in bone healing including the putative effects of (1) cholesterol, (2) hyperlipidemia, and (3) low vitamin D intake. Moreover, the prominent influence of osteocytes and immune cells is discussed as being key regulators during dental implant osseointegration and maintenance. These cells are of crucial importance in the presence of biofilm accumulation and their associated byproducts that leads to hard and soft tissue breakdown; the so called peri-implantitis. Factors that could negatively impact osteoclastogenesis or osteal macrophage activation should be monitored in future research including implant placement/torque protocols, bone characteristics, as well as meticulous maintenance programs to favor osseointegration and future long-term stability and success of dental implants. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2075-2089, 2017.

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Section: Cholesterol and Fatty Acidsmentioning

confidence: 99%

Basis of bone metabolism around dental implants during osseointegration and peri‐implant bone loss

Ínsua

Monje

Wang

et al. 2017

J Biomedical Materials Res

188

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“…Furthermore, in another study, after 8 weeks of oral vitamin D treatment, increased peri‐implant bone density, bone‐implant contact, and peri‐implant trabecular microstructure were demonstrated in ovariectomized rats . In an animal model, in which the effect of topical application of a solution of vitamin D (10%) on the surface of immediate implants was evaluated, it was shown that there was a positive correlation between vitamin D and the early stages of osseointegration, and vitamin D improved new bone formation . Similarly, in a case‐control study investigating the failure of immediate implant osseointegration, it was concluded that severe vitamin D deficiency had a negative effect on osseointegration .…”

Section: Discussionmentioning

confidence: 91%

“…6 In an animal model, in which the effect of topical application of a solution of vitamin D (10%) on the surface of immediate implants was evaluated, it was shown that there was a positive correlation between vitamin D and the early stages of osseointegration, and vitamin D improved new bone formation. 25 Similarly, in a case-control study investigating the failure of immediate implant osseointegration, it was concluded that severe vitamin D deficiency had a negative effect on osseointegration. 26 Waskiewicz et al reported the importance of vitamin D in different biological and metabolic processes and in the regulation of phosphocalcic metabolism and reported that vitamin D deficiency may be a risk factor that adversely affects bone healing and osseointegration in dental implants.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of FGF‐23 and 25(OH)D₃ levels in peri‐implant sulcus fluid in peri‐implant health and diseases

Acipinar

Hendek

Olgun

et al. 2019

Clin Implant Dent Rel Res

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Background There are limited studies to date investigating vitamin D and fibroblast growth factor (FGF)‐23 in different peri‐implant conditions. Purpose To evaluate the peri‐implant sulcus fluid (PISF) FGF‐23 and 25‐hydroxy‐vitamin D3 (25(OH)D3) levels in peri‐implant health and diseases. Materials and Methods A total of 90 dental implant sites (peri‐implant healthy group [n = 30], peri‐implant mucositis group [n = 30], and peri‐implantitis group [n = 30]) in 53 participants were included in the study. Probing depth (PD), clinical attachment level (CAL), suppuration (S), modified plaque index (mPI), gingival index (GI), modified sulcus bleeding index (mSBI), and keratinized mucosa width (KMW) were recorded as clinical parameters, and PISF samples were obtained. FGF‐23 and 25(OH)D3 levels were analyzed by enzyme‐linked immunosorbent assay. Results There were no statistically significant differences in FGF‐23 concentrations among the groups (P > .05). The 25(OH)D3 concentration was significantly lower in peri‐implantitis group compared with the other two groups (P < .05). The mean total amount of FGF‐23 in the peri‐implantitis group was significantly higher than the peri‐implant healthy group whereas 25(OH)D3 total amount was significantly lower in the peri‐implantitis group than the peri‐implant healthy group. The 25(OH)D3 concentration was significantly negatively correlated with CAL, PD, mPI, S, GI, and mSBI and statistically significant relationship was found between FGF‐23 total amount and these clinical parameters (P < .05). There was a negligible positive correlation between 25(OH)D3 and FGF‐23 concentrations (τ = 0.169; P = .018). Conclusion Within the limitations of this study, it can be concluded that FGF‐23 and vitamin D seems to affect peri‐implant bone health, and further studies are needed to explain the association between FGF‐23 and 25(OH)D3 in peri‐implant conditions.

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“…A total of 14 studies were considered for the literature review, 9 were animal studies and 5 studies used human subjects. The literature review in animals demonstrated that administration of vitamin D can induce bone formation as well as strengthen and support the interaction between bone and implants 29 31 . Locally applied vitamin D may escalate the bone-implant contact percentage by 10% 31 .…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, studies have found that vitamin D is markedly beneficial to the cardiovascular 16 , immune and respiratory systems 17,18 . Even though the significance of vitamin D and its involvement in bone metabolism have been well documented [19][20][21][22][23][24][25][26][27][28][29][30][31] , limited studies have been conducted on the effects of osseointegration of implants in dental patients. Specifically, the majority of them have been performed in animal experimental models [20][21][22][23][24][27][28][29]31 and only a small number in humans [15][16][17][18] .…”

Section: Introductionmentioning

confidence: 99%

The role of vitamin D in dental implants osseointegration

Vesala¹,

Dontas²

2020

JRPMS

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Dental implants currently constitute a well-established solution for both functional and aesthetic restoration of complete and partial edentulism. Osseontegration, however, is a complex and multifactorial phenomenon bearing concerns as to its strong association to implant, prosthetics and surgical protocols, as well to patients themselves. This literature review aims to research into potential correlations linking the osseointegration process in dental implants to low levels of vitamin D in dental patients. A number of scientific articles were retrieved from PubMed and MEDLINE databases, using the following key words: "vitamin D deficiency"; "osseointegration"; and "vitamin D AND dental implants". Αll retrieved studies were limited to those involving human and animal experimental models, and only articles written in English. Nine animal studies investigated the osseointegration process in dental implants that may be attributed to the effects of vitamin D; and five studies used human subjects. However, none of the said studies demonstrated statistically significant differences. A number of patients, especially those with severe deficiency, reported beneficial outcomes following vitamin D systemic administration prior the surgery. In such patients, is important to maintain vitamin D levels, as it ensures bone reconstruction around the implant.

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Topical applications of vitamin D on implant surface for bone‐to‐implant contact enhance: a pilot study in dogs part II

Abstract: With the limitation of animal studies, topical application of vitamin D on dental implants could reduce crestal bone loss and increase 10% more bone-to-implant contact at 12-week follow-up period.

Cited by 34 publications

References 46 publications

Basis of bone metabolism around dental implants during osseointegration and peri‐implant bone loss

Basis of bone metabolism around dental implants during osseointegration and peri‐implant bone loss

Evaluation of FGF‐23 and 25(OH)D₃ levels in peri‐implant sulcus fluid in peri‐implant health and diseases

The role of vitamin D in dental implants osseointegration

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Topical applications of vitamin D on implant surface for bone‐to‐implant contact enhance: a pilot study in dogs part II

Abstract: With the limitation of animal studies, topical application of vitamin D on dental implants could reduce crestal bone loss and increase 10% more bone-to-implant contact at 12-week follow-up period.

Cited by 34 publications

References 46 publications

Basis of bone metabolism around dental implants during osseointegration and peri‐implant bone loss

Basis of bone metabolism around dental implants during osseointegration and peri‐implant bone loss

Evaluation of FGF‐23 and 25(OH)D3 levels in peri‐implant sulcus fluid in peri‐implant health and diseases

The role of vitamin D in dental implants osseointegration

Contact Info

Product

Resources

About

Evaluation of FGF‐23 and 25(OH)D₃ levels in peri‐implant sulcus fluid in peri‐implant health and diseases