Topical application of the hexane fraction ofLacistema pubescensreduces skin inflammation and cytokine production in animal model

Abstract

The mechanism of action of HLP was associated with the inhibition of several pro-inflammatory mediators, including cytokines, arachidonic acid metabolites and histamine, which suggested a glucocorticoid-like effect, reinforced by the presence of the steroid sitosterol. This is the first report on anti-inflammatory activity of L. pubescens leaves.

Comparative analysis of Lacistema pubescens and dexamethasone on topical treatment of skin inflammation in a chronic disease model and side effects

“…As described in our previous study, HLP showed a probable glucocorticoid mechanism of action . For this reason, this test was performed to verify whether HLP induces cutaneous atrophy, which is a typical adverse reaction associated with the prolonged topical use of glucocorticoid drugs .…”

“…Recently, our group demonstrated the acute topical anti‐inflammatory effect of the HLP of L. pubescens leaves in mice. The HLP mechanism of action was associated with the inhibition of several pro‐inflammatory mediators, including cytokines, arachidonicacid metabolites and histamine, which suggested a glucocorticoid‐like effect, reinforced by the presence of the steroid sitosterol …”

The anti-inflammatory effects of Yunnan Baiyao are involved in regulation of the phospholipase A2/arachidonic acid metabolites pathways in acute inflammation rat model

“…Inflammation paws were collected and fixed in 70% ethanol for 24 h and then preserved in 10% formalin. Subsequently, the paws were dehydrated, blocked in paraffin and then sectioned with a microtome (5 µm) ( 26 ). The sections were stained with haematoxylin and eosin for the evaluation of histopathological changes.…”