Topical application of honey in the management of chemo/radiotherapy-induced oral mucositis: A systematic review and network meta-analysis

Yang, Chao; Gong, Guangzhe; Jin, Enshi; Han, Xiaolei; Yang, Zhuo; Yang, Seung-Han; Song, Bo; Zhang, Yingshi; Piao, Chengzhe

doi:10.1016/j.ijnurstu.2018.08.007

Cited by 57 publications

(40 citation statements)

References 46 publications

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“…Pooling data from studies using different types of honey may compromise the findings since some types of honey may be more effective at mitigating RIOM than others. One MA [21] found that the type of honey did not confound the findings; another MA [18] found local and pure natural honey efficacious and Manuka honey not efficacious at mitigating RIOM. An SR [22] reviewed thirteen studies which found conventional honey to be efficacious and four studies which found Manuka honey not to be efficacious.…”

Section: Discussionmentioning

confidence: 99%

“…Seven of these studies [13][14][15][16][17][18][19] found statistically significantly fewer patients in the honey group had severe OM; the other two studies [20,21] found no statistically significant difference between the groups. Four studies [16][17][18]21] measured onset of OM. All found onset of OM was delayed in the honey group although only the first three calculated statistical significance.…”

Section: Honeymentioning

confidence: 99%

“…One study [13] reported AEs but it is more likely these were related to the OM itself rather than the product. One study [18] reported that there were no AEs related to honey.…”

Section: Honeymentioning

confidence: 99%

“…Quality of studies Only two out of the twelve studies [18,21] investigating the use of honey to mitigate RIOM had moderate methodological quality. The other ten had low methodological quality.…”

Section: Honeymentioning

confidence: 99%

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A systematic review of interventions to mitigate radiotherapy-induced oral mucositis in head and neck cancer patients

Davy¹,

Heathcote²

2020

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Background Oral mucositis is a debilitating consequence of radiotherapy in patients with head and neck cancers. Radiationinduced oral mucositis (RIOM) can cause pain and weight loss, reduce quality of life and affect treatment outcomes. Methods A systematic review was undertaken to identify and examine the efficacy of low-cost interventions to mitigate RIOM and to develop clinical guidelines based on the evidence. Results The author identified three interventions: benzydamine hydrochloride mouth rinse (BHM), honey and oral glutamine (OG). The search identified twenty-four studies in total. Four studies examined BHM; all findings were favourable, although only one had moderate methodological quality, and the rest were low. The product was poorly tolerated by some participants in one study. Twelve studies examined honey. Eleven of these had favourable results; two studies had moderate methodological quality, and the rest were low. Eight studies examined OG. Six of these had favourable results; two studies had moderate methodological quality, and the rest were low. Conclusion The author cannot recommend BHM to mitigate RIOM due to the overall low quality of the studies and poor tolerance to the product. The author cannot recommend honey to mitigate RIOM due to weak evidence supporting the intervention. The author can recommend OG to mitigate RIOM. There is a need for high-quality studies with a consensus of the methodology to reduce heterogeneity and examination of the cost-effectiveness of the interventions.

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Section: Discussionmentioning

confidence: 99%

Section: Honeymentioning

confidence: 99%

“…One study [13] reported AEs but it is more likely these were related to the OM itself rather than the product. One study [18] reported that there were no AEs related to honey.…”

Section: Honeymentioning

confidence: 99%

Section: Honeymentioning

confidence: 99%

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A systematic review of interventions to mitigate radiotherapy-induced oral mucositis in head and neck cancer patients

Davy¹,

Heathcote²

2020

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“…To estimate the effect sizes for the categorical outcomes using our outcome data, we computed the odds ratio (OR) with 95% confidence intervals (CI, for standardized meta-analysis) and 95% credible intervals (CrI, for network meta-analysis). In order to address heterogeneity relating to the outcomes documented in each of the selected study records, we used the random effects model, which is best suited to resolving heterogeneity in standardized meta-analyses (27,28), to record the two-sided P value and I 2 statistic (the ratio of true heterogeneity to total observed variation) measures.…”

Section: Data Synthesis and Statistical Analysismentioning

confidence: 99%

The Coexistence of Genetic Mutations in Thyroid Carcinoma Predicts Histopathological Factors Associated With a Poor Prognosis: A Systematic Review and Network Meta-Analysis

et al. 2020

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Purpose: Genetic mutations may play an important role in the progression and invasion of thyroid carcinoma (TC), and their coexistence may result in mutational synergy. The presence of the BRAF V600E mutation, as well as mutations affecting the TERT promoter, RAS, CHEK2 and RET/PTC, may all have an impact on prognosis. The aim of this study was to explore whether synergy between the coexistent mutations predicts histopathological prognostic factors that influence disease outcome. Methods: A comprehensive literature search of PubMed, Embase and the Cochrane Library, from their inception until January 2020. Primary outcomes included: disease stage, lymph node metastasis, extrathyroidal extension and distant metastasis; while, secondary outcomes included: tumor recurrence, mortality, invasion of thyroid capsule, multiplicity, presented as an odds ratio (OR) with 95% credible intervals (CrI). Results: 27 publications (comprising 9 active intervention arms), involving 8,388 TC patients, were selected. Network meta-analytic estimates of active interventions contrasted with other active interventions, with random effects, were calculated. In terms of outcomes focus on overall TC, BRAF V600E + TERT co-mutation ranked highest for diseases stage (OR = 5.74, 95% CrI: 3.09-10.66), as well as lymph node metastasis, extrathyroidal extension (5.74, 4.06-8.10), tumor recurrence (7.21, 3.59-14.47), and invasion of the thyroid capsule (3.11, 1.95-4.95). BRAF V600E + TERT co-mutation ranked secondary in distant metastasis, mortality, and multiplicity that ranked highest was TERT+ RAS or RAS. When we were limited to the study of patients with papillary TC (PTC), BRAF V600E + TERT always ranked highest for primary outcomes: disease stage (6.39, 3.13-13.04), lymph node metastasis, extrathyroidal extension (5.80,3.89-8.64) and

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Pediatric oncologists' perspectives on the use of complementary medicine in pediatric cancer patients in Switzerland: A national survey‐based cross‐sectional study

et al. 2022

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Background: There is a widespread use of complementary therapies among pediatric cancer patients. Previous studies provided evidence that communication between pediatric oncologists (POs) and patients/families about the use of these therapies is often incomplete. Furthermore, nationwide studies on this topic are rare. Aims:We assessed POs' perspectives on the use of complementary medicine (CM) in Switzerland, on the basis of an edited survey previously used in a nationwide study. Methods and Results:A link to an online survey was sent by e-mail to each of the fifty-two eligible pediatric oncologists in all nine Swiss Pediatric Oncology Group (SPOG) centers. Eligible respondents were board-certified (Switzerland or abroad)POs currently working at a SPOG center. The survey was available for a total period of 2 months.

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Topical application of honey in the management of chemo/radiotherapy-induced oral mucositis: A systematic review and network meta-analysis

Cited by 57 publications

References 46 publications

A systematic review of interventions to mitigate radiotherapy-induced oral mucositis in head and neck cancer patients

A systematic review of interventions to mitigate radiotherapy-induced oral mucositis in head and neck cancer patients

The Coexistence of Genetic Mutations in Thyroid Carcinoma Predicts Histopathological Factors Associated With a Poor Prognosis: A Systematic Review and Network Meta-Analysis

Pediatric oncologists' perspectives on the use of complementary medicine in pediatric cancer patients in Switzerland: A national survey‐based cross‐sectional study

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