A systematic review of interventions to mitigate radiotherapy-induced oral mucositis in head and neck cancer patients

Davy, Catrina; Heathcote, Sharron

doi:10.1007/s00520-020-05548-0

Cited by 36 publications

(30 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, severe oral mucositis induced by radiotherapy can directly lead to reduced food intake, malnutrition and weight loss. Many studies have investigated in an attempt to reduce mucositis and weight loss [ 19 , 20 ]. Catrina et al [ 19 ] identified twenty-four studies, honey and the use of benzydamine hydrochloride mouthwash were not advised due to the generally poor quality of the research and the scant evidence supporting the intervention.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have investigated in an attempt to reduce mucositis and weight loss [ 19 , 20 ]. Catrina et al [ 19 ] identified twenty-four studies, honey and the use of benzydamine hydrochloride mouthwash were not advised due to the generally poor quality of the research and the scant evidence supporting the intervention. Although the authors suggested glutamine as a method to lessen oral mucositis, there is still a need for high-quality studies with a widely accepted technique to help reduce heterogeneity.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The relationship of serum gastrin-17 and oral mucositis in head and neck carcinoma patients receiving radiotherapy

Liu

Shi

et al. 2022

Discov Onc

View full text Add to dashboard Cite

Objective The aim of this study was to analyze the relationship of serum gastrin-17 (G-17) and oral mucositis in head and neck carcinoma (HNC) patients receiving radiotherapy. Methods Serum G-17 were detected in patients before and after radiotherapy. Patients were divided into high G-17 group (baseline serum G-17 ≥ 5pmol/L) and low G-17 group (baseline serum G-17 < 5pmol/L). The severity of oral mucositis was analyzed between the two groups. Other complications such as dysphagia, salivary gland, mandible, thyroid function, larynx, pain, and weight loss were also investigated. Results Forty-two patients were analyzed in this study. The level of serum G-17 had a significant decrease after radiotherapy (7.29 ± 5.70pmol/L versus 4.93 ± 4.46pmol/L, P = 0.038). In low serum G-17 group, the incidences of grade 0, 1–2 and 3–4 of oral mucositis were 0%, 30.4%, and 69.6%, respectively. In high serum G-17 group, the incidences of grade 0, 1–2 and 3–4 of oral mucositis were 0%, 63.2%, and 36.8%, respectively. Pearson correlation analysis showed that serum G-17 was negatively correlated with oral mucositis (r=-0.595, P < 0.01). Weight loss of low G-17 group was more serious than that of high G-17 group. Conclusion Serum G-17 has a close relationship with oral mucositis. Baseline serum G-17 may be a potential predictor for the severity of oral mucositis in HNC patients receiving radiotherapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The relationship of serum gastrin-17 and oral mucositis in head and neck carcinoma patients receiving radiotherapy

Liu

Shi

et al. 2022

Discov Onc

View full text Add to dashboard Cite

show abstract

“…Up to 78% of patients in this study received high-dose radiation treatment (70Gy) with systemic therapy. A systematic review of low-cost interventions to treat radiation induced mucositis in head and neck cancer patients identi ed benzydamine hydrochloride mouth rinse, honey and oral glutamine as potential therapeutics [34]. Whilst only glutamine was recommended to mitigate radiation induced mucositis, the lack of its standardised formulation and dose have precluded its robust assessment.…”

Section: Discussionmentioning

confidence: 99%

A two-phase study investigating the benefit of additional 0.5% cocaine mouthwash to institutional standard of care mucositis management

Grover

Tang

Dhaliwal

et al. 2022

Preprint

View full text Add to dashboard Cite

Purpose Mucositis remains a challenging complication of radiotherapy or chemoradiotherapy (CRT) for head and neck cancer (HNC) patients. There is limited data on the safety or effectiveness of cocaine mouthwash (CMW) to treat mucositis. Methods This was single centre, prospective sequential cohort study in HNC patients undergoing CRT. Patients were allocated to the standard of care mucositis management (SOC arm) or SOC + 0.5% CMW (CMW arm). We assessed the benefit of CMW in the management of mucositis on patient reported quality of life (QoL) using the EORTC QLQ-C30 and H&N35 questionnaires at baseline, during CRT, at 1- and 3-months follow-up. Results 64 patients were enrolled in the SOC arm and 65 patients in the CMW arm. Baseline characteristics were similar between the arms. Most patients were male (80-89%) who received 70Gy of radiation (63-78%) with cisplatin (86-94%). Grade 2 and 3 mucositis were experienced in up to 51.7% and 28.8% patients respectively, but no meaningful differences were observed between the arms. Morbidity was high without significant differences observed between arms, with high hospitalisation rates (45.3-53.8%), need for enterostomy feeding (21.9-36.9%) and opioid analgesic prescription (≤56.5%). Weight at 3-month follow-up was significantly lower compared to baseline for both arms but was not significantly different between the arms. No significant differences were observed in patient reported QoL between the arms (adjusted and unadjusted), or when assessed using a 10-point clinically meaningful difference threshold (p>0.05). Conclusion Addition of CMW to SOC management did not demonstrate benefit or harm. CRT associated mucositis has significant morbidity.

show abstract

“…In addition, it induces oral mucositis that may favor the emergence of opportunistic infections, fever, anorexia, hemorrhage, severe pain, dysphagia and dysgeusia [111]. Oral glutamine has been recommended to mitigate radiotherapy-induced oral mucositis in head and neck cancer patients but other effective interventions are needed [112]. As mentioned previously, probiotics may participate indirectly in re-epithelization and tissue regeneration due to their potential to: (1) influence immune-regulating factors (e.g., kB nuclear factor, toll-like receptors in dendritic cells), (2) modulate inflammatory mediator levels (e.g., cytokines such as IL-1β, TNF-α, IL-6 and IL-15 and chemokines such as IL-8); and (3) induce the production of proteolytic enzymes involved in tissue remodeling (MMPs).…”

Section: Probiotics In Oral Wound Healing and Oral Mucositis Related With Cancer Therapymentioning

confidence: 99%

Probiotics in Oral Health and Disease: A Systematic Review

Saïz¹,

Taveira²,

Alves³

2021

Applied Sciences

View full text Add to dashboard Cite

Purpose: Probiotics may exclude or antagonize oral pathogens and be useful to prevent oral dysbiosis and treat oral diseases. The objective of this review was to assess the benefits of probiotics in oral health and disease, and in dental practice; Methods: Primary articles published between January 2012 and 30 December 2020 with full text available were searched in PubMed, ClinicalTrials.gov, ScienceDirect, Google Scholar, B-on, and SciELO; Results: The electronic search identified 361 references of which 91 (25.2%) met all the inclusion criteria. In total, data from 5374 participants with gingivitis, periodontitis, peri-implantitis, caries, orthodontic conditions, halitosis, or oral conditions associated with chemo-radiotherapy were included. Despite major inconsistencies between clinical trials, probiotics have been found to contribute to reduce S. mutans counts (L. paracasei SD1), reduce probing depth in chronic periodontitis (B. animalis subsp. lactis DN-173010 with L. reuteri), reduce levels of volatile sulfur compounds and halitosis (L. salivarius WB21), treat oral mucositis and improve the quality of life of patients undergoing cancer chemo-radiotherapy (L. brevis CD2). Combinations of probiotic bacteria tend to lead to higher clinical efficacy than any individual probiotic agent; Conclusion: Oral probiotics influence favorably the oral microbiota and provide benefits to the oral ecosystem in periodontal diseases, cariology, halitosis, orthodontics and management of oral mucositis resulting from cancer treatment. However, the use of probiotics in dental practice or in self-management preventive strategies requires additional well controlled clinical trials to determine the most effective probiotic combinations, the most appropriate probiotic vehicle, and the frequency of administration.

show abstract

A systematic review of interventions to mitigate radiotherapy-induced oral mucositis in head and neck cancer patients

Cited by 36 publications

References 34 publications

The relationship of serum gastrin-17 and oral mucositis in head and neck carcinoma patients receiving radiotherapy

The relationship of serum gastrin-17 and oral mucositis in head and neck carcinoma patients receiving radiotherapy

A two-phase study investigating the benefit of additional 0.5% cocaine mouthwash to institutional standard of care mucositis management

Probiotics in Oral Health and Disease: A Systematic Review

Contact Info

Product

Resources

About