Topical Antibiotic Elution in a Collagen Rich Hydrogel for Healing of Infected Wounds

Rangel, Uriel J. Sanchez; Oda, Hiroki; Akerman, Jack; Wang, Zhen; Fox, Paige M.

doi:10.1097/01.gox.0000721056.23100.54

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“…Collagen absorbs exudate, but also has an important function in the natural healing process of wounds by inducing coagulation and scar formation. If collagen is combined with dermal cells, growth factors, and cytokines in the patient's body, the reepithelization process is accelerated [11][12][13]. In addition, sodium carboxymethylcellulose (CMC) also exhibits high affinity for water, has a low price and excellent skin compatibility (it's physiologically harmless), being already used in treatment devices, especially for burns, being also able to assure the desired mechanical strength.…”

Section: Introductionmentioning

confidence: 99%

Collagen-Carboxymethylcellulose Biocomposite Wound-Dressings with Antimicrobial Activity

et al. 2021

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Microbial infections associated with skin diseases are frequently investigated since they impact on the progress of pathology and healing. The present work proposes the development of freeze-dried, glutaraldehyde cross-linked, and non-cross-linked biocomposite dressings with a porous structure, which may assist the reepithelization process through the presence of collagen and carboxymethylcellulose, along with a therapeutic antimicrobial effect, due to silver nanoparticles (AgNPs) addition. Phisyco-chemical characterization revealed the porous morphology of the obtained freeze-dried composites, the presence of high crystalline silver nanoparticles with truncated triangular and polyhedral morphologies, as well as the characteristic absorption bands of collagen, silver, and carboxymethylcellulose. In vitro tests also assessed the stability, functionality, and the degradability rate of the obtained wound-dressings. Antimicrobial assay performed on Gram-negative (Escherichia coli), Gram-positive (Staphyloccocus aureus) bacteria, and yeast (Candida albicans) models demonstrated that composite wound dressings based on collagen, carboxymethylcellulose, and AgNPs are suitable for skin lesions because they prevent the risk of infection and have prospective wound healing capacity. Moreover, the cell toxicity studies proved that the obtained materials can be used in long time treatments, with no cytotoxic effects.

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Section: Introductionmentioning

confidence: 99%