Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris

Marks, Dustin H.; Prasad, Sonya; Souza, Brianna De; Burns, Lindsay H.; Senna, Maryanne M.

doi:10.1007/s40257-019-00493-z

Cited by 15 publications

(10 citation statements)

References 46 publications

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“…Systemic anti-androgens are effective against acne [ 7 , 64 ]. Topical anti-androgens are effective against acne [ 65 ]. IGF-1 modulators have also been reported as effective treatments for acne [ 66 ].…”

Section: Potential Targets For Acne Managementmentioning

confidence: 99%

Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis

Kurokawa

Layton

Ogawa

2021

Dermatol Ther (Heidelb)

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Previous approaches to acne management have focused on the four main factors implicated in acne, namely, androgen-mediated sebogenesis (considered integral to acne), hyperkeratinization, colonization with Cutibacterium acnes, and inflammation related to both innate and adaptive mechanisms. Recent advances have facilitated potential novel approaches to acne management, as the pathophysiology and the immunological aspects related to acne and wound healing have evolved. Particular targets that have been shown to be closely involved in acne pathophysiology and wound healing include interleukin (IL)-1b, IL-17, IL-23, and tumor necrosis factor alpha (TNFa). Biological antibodies targeting IL-1b, IL-17, IL-23, and TNFa could provide novel approaches for treating severe acne and related disorders. Acne

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Section: Potential Targets For Acne Managementmentioning

confidence: 99%

Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis

Kurokawa

Layton

Ogawa

2021

Dermatol Ther (Heidelb)

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“…Androgenetic alopecia (AGA), also known as male-pattern baldness, is one of the most prevalent chronic disorders in dermatology caused by the progressive loss and thinning of scalp hair and affects hundreds of millions of adult men 183 . Currently, most treatments for hair loss consist of medication or hair transplantation.…”

Section: The Applications Of Nanocarrier- or Mn-based Transdermal Del...mentioning

confidence: 99%

Advanced nanocarrier- and microneedle-based transdermal drug delivery strategies for skin diseases treatment

Qu¹,

Geng²,

Liu³

et al. 2022

Theranostics

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Skin diseases are the fourth leading cause of nonfatal and chronic skin diseases, acting as a global burden and affecting the world economy. Skin diseases severely impact the patients' quality of life and have influenced their physical and mental state. Treatment of these skin disorders with conventional methods shows a lack of therapeutic efficacy, long treatment duration, recurrence of the condition, and systemic side effects due to improper drug delivery. However, these pitfalls can be overcome with the applications of advanced nanocarrier- and microneedle (MN)-based transdermal drug delivery strategies that provide efficient site-specific drug delivery at the target site. These advanced transdermal drug delivery strategies can be more effective than other drug administration routes by avoiding first-pass metabolism, enhancing the drug concentration in local skin lesions, and reducing systemic toxicity. Compared with traditional transdermal delivery methods, nanocarrier- or MN-based drug delivery systems are painless, noninvasive, or minimum-invasive and require no expensive equipment. More importantly, they can introduce more advanced functions, including increased skin penetration efficiency, controlled drug release rates, enhanced targeting abilities, and theranostic functions. Here, the emergence of versatile advanced transdermal drug delivery systems for the transdermal delivery of various drugs is reviewed, focusing on the design principles, advantages, and considerations of nanocarrier- and MN-based transdermal drug delivery strategies and their applications in treating diverse skin diseases, including psoriasis, dermatitis, melanoma, and other skin diseases. Moreover, the prospects and challenges of advanced transdermal delivery strategies for treating dermatological disorders are summarized.

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“…It is the first anti-androgen drug in clinic and has strong resistance to androgen and progesterone activity . Cyproterone acetate can be used to treat male sexual dysfunction, prostatic hypertrophy and prostate cancer, precocious puberty, hirsutism in women, acne, and menopausal syndrome. , …”

Section: Introductionmentioning

confidence: 99%

“…3 Cyproterone acetate can be used to treat male sexual dysfunction, prostatic hypertrophy and prostate cancer, precocious puberty, hirsutism in women, acne, and menopausal syndrome. 4,5 Cyproterone acetate is exposed to ethyl acetate and chloroform during the process of production; thus, the solubility results of cyproterone acetate in the solvents are very helpful in the production process. However, we did not find the solubility results of cyproterone acetate in ethyl acetate and chloroform from any published paper.…”

Section: Introductionmentioning

confidence: 99%

Determination and Correlation of the Solubility of Cyproterone Acetate in Fourteen Pure Solvents and Water + Ethanol Mixed Solvents at Temperatures from 273.15 to 318.15 K

Ning

Kuang²,

2020

J. Chem. Eng. Data

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The solubility of cyproterone acetate in 14 pure solvents, such as methyl tert-butyl ether, xylene, 1-butanol, 1-propanol, tetrahydrofuran, ethanol, ethyl acetate, isopropanol, acetone, acetonitrile, dimethylformamide, methanol, water, and trichloromethane, and mixed solvents of water + ethanol have been determined at temperatures from 273.15 to 318.15 K by applying the analytical method of high-performance liquid chromatography. The solubility results in 14 solvents were fitted by the modified Apelblat equation, van’t Hoff equation, λh equation, NRTL equation, UNIQUAC equation, and Wilson equation. The solubility results in the binary solvents of water + ethanol were fitted by the modified Apelblat equation, van’t Hoff equation, λh equation, NRTL equation, UNIQUAC equation, Jouyban–van’t Hoff equation, and Jouyban–Apelblat equation. The solubility of cyproterone acetate in 14 pure solvents and mixed solvents increased with increasing temperature. The solubility of cyproterone acetate in the mixed solvents increased with the increasing of the mole fraction of ethanol. The computed results by way of the modified Apelblat equation, van’t Hoff equation, λh equation, NRTL equation, UNIQUAC equation, Jouyban–van’t Hoff equation, and Jouyban–Apelblat equation were matched with the actual results. The actual results and computed results are very useful in the separation and synthesis process of cyproterone acetate.

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Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris

Cited by 15 publications

References 46 publications

Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis

Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis

Advanced nanocarrier- and microneedle-based transdermal drug delivery strategies for skin diseases treatment

Determination and Correlation of the Solubility of Cyproterone Acetate in Fourteen Pure Solvents and Water + Ethanol Mixed Solvents at Temperatures from 273.15 to 318.15 K

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