Topical anti-inflammatory effect of hydroalcoholic extract of leaves of Licania rigida Benth. in mice

Santos, Enaide Soares; Oliveira-Tintino, Cícera Datiane de Morais; Correia, Denise Bezerra; Alencar, Cícero Damon Carvalho de; Sousa, Maria de Fátima; Lima, Cícera Norma Fernandes; Machado, Sara Tavares de Sousa; Gomes, Acléssia Damiana Soares; Garcia, Francisca Adilfa de Oliveira; Menezes, Irwin Rose Alencar de; Boligon, Aline Augusti; Costa, José Galberto Martins da; Coutinho, Henrique Douglas Melo; Felipe, Cícero Francisco Bezerra; Kerntopf, Marta Regina

doi:10.1016/j.phyplu.2021.100110

Cited by 3 publications

(1 citation statement)

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“…This plant is traditionally used for its antimicrobial and anticancer properties, which are associated with oxidative stress [ 13 , 14 , 15 , 16 ]. Studies have evaluated the biological and pharmacological activities of plants belonging to the same family as Licania (Chrysobalanaceae) and demonstrated their anti-inflammatory effects [ 13 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Mass Spectrometric Identification of Licania rigida Benth Leaf Extracts and Evaluation of Their Therapeutic Effects on Lipopolysaccharide-Induced Inflammatory Response

et al. 2022

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Licania rigida Benth has been evaluated as an alternative drug to treat diseases associated with inflammatory processes. This study evaluated the anti-inflammatory effects of aqueous and hydroalcoholic leaf extracts of L. rigida with inflammation induced by lipopolysaccharides in in vitro and in vivo inflammation models. The phytochemical profile of the extracts, analyzed by ultra-fast liquid chromatography coupled with tandem mass spectrometry, revealed the presence of gallic and ellagic acids in both extracts, whereas isovitexin, ferulate, bulky amino acids (e.g., phenylalanine), pheophorbide, lactic acid, and pyridoxine were detected in the hydroalcoholic extract. The extracts displayed the ability to modulate in vitro and in vivo inflammatory responses, reducing approximately 50% of pro-inflammatory cytokine secretion (TNF-α, IL-1β, and IL-6), and inhibiting both NO production and leukocyte migration by approximately 30 and 40% at 100 and 500 µg/mL, respectively. Overall, the results highlight and identify, for the first time, the ability of L. rigida leaf extract to modulate inflammatory processes. These data suggest that the leaf extracts of this plant have potential in the development of herbal formulations for the treatment of inflammation.

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