Topical Action of Salicylates in Gastrointestinal Erosion and Hemorrhage

Roth, James L. A.; Valdes-Dapena, A.; Pieses, Pracha; Buchman, E

doi:10.1016/s0016-5085(63)80007-4

Cited by 54 publications

(8 citation statements)

References 27 publications

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“…Systemic as well as local effects have been suggested as a possible mode of action of the drug (Smith, 1966). A local effect of the drug has been demonstrated from studies of the application of aspirin particles to explanted gastric mucosa (Stephens, Milton, and Loewenthal, 1966) or directly through fistulae onto the gastric mucosa of experimental animals (Roth, Valdes-Dapena, Pieses, and Buchman, 1963;. Systemic action could also be invoked but this is debatable (see Smith, 1966).…”

mentioning

confidence: 99%

Electronmicroscopic observations on the effects of orally administered aspirin and aspirin-bicarbonate mixtures on the development of gastric mucosal damage in the rat.

Rainsford¹

1975

Gut

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SUMMARYThe effects of administering a single dose of (200 mg to 50 mg/kg body weight) aspirin or an equimolar mixture of aspirin (200 mg/kg body wt) with sodium bicarbonate on the fine structure of the rat gastric mucosa were investigated in order to establish the role of particles of the drug in the development of gastric damage. The sequence of cellular events involved in the development of a lesion and the influence of short-term starvation were also investigated. Aspirin-bicarbonate solutions produced much less damage in starved rats than aspirin suspensions given at low (50 mg/kg body weight) or high therapeutic doses (200 mg/kg body weight). Also, when non-starved rats were given 200 mg/kg aspirin, only slight damage was observed. The presence of particles of the drug in intimate contact with the mucosa is thus important in the development of gastric damage. A sequence of events with time involving direct physical exfoliation of mucosal cells and selective structural damage to parietal cells followed by structural damage indicative of a disturbance to oxidative and biosynthetic functions in cells near the developing erosion was observed. The implications of these results on the development of aspirin-induced lesions are discussed.

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mentioning

confidence: 99%

Electronmicroscopic observations on the effects of orally administered aspirin and aspirin-bicarbonate mixtures on the development of gastric mucosal damage in the rat.

Rainsford¹

1975

Gut

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“…per day. Paracetamol did not have the topical irritant action of aspirin on the buccal mucous membranes of human subjects or on cat gastric mucosa (Roth, Valdes-Dapena, Pieses, and Buchman, 1963).…”

Section: Discussionmentioning

confidence: 81%

Effect of paracetamol (N-acetyl-p-aminophenol) on gastrointestinal bleeding

Goulston¹,

Skyring²

1964

Gut

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“…Davenport (5) described changes in the mucosal barrier with penetration of acetylsalicylic acid and mucosal damage. Roth et al (17) stressed the topical effect of salicylates, with epithelial desquamation, focal necrosis, and a n increased volume of free hydrochloric acid with denaturation of mucus as a possible component of the deleterious mechanism. Johnson (9) found that the deposition of acetylsalicylic acid in the pylorus-ligated rat stomach gave a n increased content of histamine in the gastric secretion.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Drugs and Gastric Mucus

Johansson

Lindquist

1971

Scandinavian Journal of Gastroenterology

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1971. Anti-Inflammatory Drugs and Gastric Mucus. Scartd. J . Gnstroent. 6, 49-54.The gastric mucus in the rat was studied by a histochemical technique after administration of calcium acetylsalicylate, oxiphenbutazone, and indomethacin. All these substances were found to reduce the mucus layer in the stomach. Salicylate appeared to cause the greatest reduction. and the results indicate that the effect on the gastric mucosa is partly locally and partly generally induced.

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Topical Action of Salicylates in Gastrointestinal Erosion and Hemorrhage

Cited by 54 publications

References 27 publications

Electronmicroscopic observations on the effects of orally administered aspirin and aspirin-bicarbonate mixtures on the development of gastric mucosal damage in the rat.

Electronmicroscopic observations on the effects of orally administered aspirin and aspirin-bicarbonate mixtures on the development of gastric mucosal damage in the rat.

Effect of paracetamol (N-acetyl-p-aminophenol) on gastrointestinal bleeding

Anti-Inflammatory Drugs and Gastric Mucus

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