Anti-Inflammatory Drugs and Gastric Mucus

Abstract

1971. Anti-Inflammatory Drugs and Gastric Mucus. Scartd. J . Gnstroent. 6, 49-54.The gastric mucus in the rat was studied by a histochemical technique after administration of calcium acetylsalicylate, oxiphenbutazone, and indomethacin. All these substances were found to reduce the mucus layer in the stomach. Salicylate appeared to cause the greatest reduction. and the results indicate that the effect on the gastric mucosa is partly locally and partly generally induced.

Prophylaxis of Postoperative Venous Thrombosis by Combined Leg Bandaging and Oxyphenbutazone Clinical and Experimental Investigations

“…Gastrointestinal bleeding has been described as a side-effect of treatment with oxyphenbutazone. Administration in suppositories does not probably make any difference, because the bleeding is due to a systemic reaction and not to a local effect on the mucosa (Johansson et al 1971). In the present investigation blood in faeces was equally common before as during and after medication and was not such as to require withdrawal of the compound.…”

“…Schmid et al (1965) found oxyphcnbutazone in an oral dose of 800 mg a day in man to increase the secretion of the gastric juice, to produce a small decrease in pH, and to inhibit gastric peristalsis, but to have no effect on the pepsin activity. Johansson et al (1971) showed oxyphenbutazone per os to reduce the mucin content of the gastric mucosa in rats. They also deposited the drug directly in the duodenum via a tube and found it to have a similar effect on the gastric mucosa and therefore concluded that the effect was generalised.…”

“…Whether such haemorrhage is due to local irritation by the preparation, to allergy. or to a generalised effect via the hypophysis and/or adrenals is still obscure (Johansson et al 1971). Schmid et al (1965) found oxyphcnbutazone in an oral dose of 800 mg a day in man to increase the secretion of the gastric juice, to produce a small decrease in pH, and to inhibit gastric peristalsis, but to have no effect on the pepsin activity.…”

Recycled-Aggregate Bedding Mortars for Repair of Historical Buildings

“…Nevertheless, especially due to the increasingly severe climatic conditions in city centres, a further kind of sulphate source in masonry cannot be neglected. This originates from heterogeneous oxidation [25,26] in liquid phase of sulphur dioxide contained in emissions from combustion of both light and fuel oils.…”

Πειραματική Μελέτη Της Εξουδετερωτικής Ικανότητος Του Λεπτού Εντέρου Κυνών Δι'όξινα Και Αλκαλικά Διαλύματα

“…Τα οξέα έλκη τα ανα πτυσσόμενα εις τον στόμαχον και το 12/λον μετά χορήγησιν διαφόρων φαρμάκων και κυρίως άκετυλοσαλικυλικοΰ οξέος ή κατόπιν σοβαρών εγκαυμάτων, απεδείχθη οτι δεν οφείλονται εις αϋξησιν τής γαστρικής όξύτητος, ήτις παραμένει φυσιολογική ('Αθανασιάδης και συν. 1972 2 , Brodie και Hooke 1971 10 , Krantz και Carr 1965 44 , Russell και Goldberg 1970 62 , Pfeiffer και Lewandowski 1971 53 ) ή είναι ολίγον ηύξημένη (Καλλιτεράκης και Νικολαΐδης 1971) 38 , αλλά ε'ις έλάττωσιν τής ποσότητος και άλλοίωσιν τής ποιότητος τής έκκρινομένης βλέννης (Wise 1972 77 , Johanson και Lindquist 1971 35 , Reed και συν. 1968 54 , Menguy και Masters 1965 48 ), ήτις οϋτω δέν είναι πλέον ικανή να εξάσκηση τον προστατευτικόν αυτής ρόλον, μηχανικόν ή χημικόν, επί τής διαβρωτικής δράσεως του HCl επί του βλεννογόνου τοΰ στομάχου ή του 12/λου.…”